DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Git and agap1

DIOPT Version :9

Sequence 1:	NP_610599.3	Gene:	Git / 36122	FlyBaseID:	FBgn0033539	Length:	731	Species:	Drosophila melanogaster
Sequence 2:	XP_009300560.1	Gene:	agap1 / 100148154	ZFINID:	ZDB-GENE-130405-1	Length:	1255	Species:	Danio rerio

Alignment Length:	241	Identity:	71/241 - (29%)
Similarity:	108/241 - (44%)	Gaps:	46/241 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 RGKSRLQTEVCGDCGAGDPSWASINRGILLCADCCSVHRSLGRHISIVKSLRQGNWEPSVLNFVN 103
            ||.:|     |.||.|.:|.|||:|.|.|:|.:|..:||:||.|:|.|:||....|...::..::
Zfish  1016 RGNTR-----CVDCEAQNPDWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDEWPLELIKVMS 1075

  Fly   104 SLNAHGANSVWEHHLLDGSTNSTGGKHVPRWRKPTPKDALHPTKSDFIKAKHVNLTFVLKPSLQD 168
            ::....||||||       .|:.|.      .||.| ||....:..:|:||:....|:
Zfish  1076 AIGNELANSVWE-------ANAQGR------LKPAP-DASREERERWIRAKYEQKLFL------- 1119

  Fly   169 DDDGNGSAGCLEQELSRQLHASVRTSNLETSLRFLVQGADPNYYHEDKLS---------TPLHMA 224
                 .|..|.|..|.:||..:....:|...:..|..|:      .|:::         |.||:|
Zfish  1120 -----ASLTCTELSLGQQLLRATAEEDLRLVVILLAHGS------RDEVNETCGEGDGRTALHLA 1173

  Fly   225 AKFGQASQIEMLLIYGADVNALDGNGMTPLELARANNHNTIAERLL 270
            .:.|.....::|:.||.|:.|.|.:..|.|..||..|.....:.||
Zfish  1174 CRKGNVVITQLLVWYGVDIMARDAHSNTALAYARQANSQECMDVLL 1219

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Git	NP_610599.3	ArfGap	48..164	CDD:279720	40/115 (35%)
		Ank_2	187..279	CDD:289560	23/93 (25%)
		ANK	<187..270	CDD:238125	21/91 (23%)
		ANK repeat	187..213	CDD:293786	4/25 (16%)
		ANK repeat	215..247	CDD:293786	11/40 (28%)
		ANK repeat	249..279	CDD:293786	7/22 (32%)
		GIT_SHD	314..342	CDD:285690
		GIT	374..404	CDD:128828
		GIT1_C	609..727	CDD:289013
agap1	XP_009300560.1	Centaurin_gamma	439..601	CDD:133303
		RAS	440..607	CDD:214541
		PH_AGAP	716..989	CDD:241281
		PH	719..>783	CDD:278594
		PH	<933..984	CDD:278594
		ArfGap	1008..1118	CDD:279720	42/120 (35%)
		Ank_2	1133..1223	CDD:289560	23/93 (25%)
		ANK	1133..>1222	CDD:238125	23/93 (25%)
		ANK repeat	1165..1196	CDD:293786	10/30 (33%)
		ANK repeat	1198..1223	CDD:293786	7/22 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810