DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Git and asap1

DIOPT Version :9

Sequence 1:	NP_610599.3	Gene:	Git / 36122	FlyBaseID:	FBgn0033539	Length:	731	Species:	Drosophila melanogaster
Sequence 2:	XP_031759002.1	Gene:	asap1 / 100036721	XenbaseID:	XB-GENE-1013472	Length:	1136	Species:	Xenopus tropicalis

Alignment Length:	757	Identity:	157/757 - (20%)
Similarity:	246/757 - (32%)	Gaps:	249/757 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LDHSDPATPTISTRSKMPRGKSRLQ---------------TEVCGDCGAGDPSWASINRGILLCA 70
            |.:|......::.|.....|:|.|:               .|||.|||:.||:|.|.|.|||.|.
Frog   414 LTNSKEDALNMAFRGDQSTGESSLEDLTKAIIDDVQKTPGNEVCCDCGSPDPTWLSTNLGILTCI 478

  Fly    71 DCCSVHRSLGRHISIVKSLRQGNWEPSVLNFVNSLNAHGANSVWEHHLLDGSTNSTGGKHVPRWR 135
            :|..:||.:|.|||.::||.......|.|....::..:..|.:.|.:||..|.
Frog   479 ECSGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEGNLLSPSA------------ 531

  Fly   136 KPTPKDALHPTKSDFIKAKHVNLTF------------------------------------VLKP 164
            ||:|...:...| ::|.||:|...|                                    :::|
Frog   532 KPSPSSDMIARK-EYITAKYVERRFSRKICSTGAEKLNELLEAVKSRDLLALIQVYAEGVEIMEP 595

  Fly   165 SLQDDDDGNGSAGCLEQELSRQLHASVRTSNLETSL---RFLVQGADPNYYHEDKLSTPLHMAAK 226
            .|:...:...:|          ||.:|||:: .|||   .||||..........|.:|.||....
Frog   596 LLESGQEPGETA----------LHYAVRTAD-HTSLPLVDFLVQNCGNLDKQTGKGNTALHYCCL 649

  Fly   227 FGQASQIEMLLIYGADVNALDGNGMTPLELARANNHNTIAERLLDAMYDVTDRIITFLGGKKPDH 291
            :.:...:::||.....::|::..|.|..::|:........|.:..|           |.||...|
Frog   650 YNKPECLKLLLRGKPTIDAVNHIGETAFDVAKRQKAAQCEELVSQA-----------LAGKLNPH 703

  Fly   292 ASGRHMIIPDANGADISEQLKIARGKLQLVPNKMFEELVMDLYDEVDRRECEAIWSTSTLNADHA 356
            ....:    |.|                 :..:..:|...||.|:           .|.:..:.:
Frog   704 VHVEY----DWN-----------------LRQEEMDESDDDLEDK-----------PSPIKKERS 736

  Fly   357 TVPFLPANPFLSATRNQGRQKLARFNRAEFTGLLTDVLVDAMRRQNMANLRPMDAPVAGHQSLQS 421
            ..|    ..|..::....:.||:      ..|..|                |.|.        |.
Frog   737 PRP----QSFCHSSSISPQDKLS------LPGFST----------------PRDK--------QR 767

  Fly   422 LPYA--NNSMLLGSFEQGGHDPNLSDDEPIYDPVASDDDYAPVPPMAQQAIVHTPPRSANSHNEM 484
            |.|.  .|.:.:.:          |.|.|. .|.|.      .||:        |||:|......
Frog   768 LSYGAFTNQIFMST----------STDSPT-SPTAD------APPL--------PPRNAGKVASG 807

  Fly   485 ETLRKQLNDYKSEINQLKNVVQMLSSENTQLKSKFSSASNNSVYDEPLRIDLSLSSPDTEHEPLS 549
            .|....|                    :||..|..|:.|.......|.....:||.|     |..
Frog   808 PTSTLPL--------------------STQSPSGSSTLSKKRPPPPPPGHKRTLSDP-----PSP 847

  Fly   550 LPEGGTANGESGSSNDSSNQSTIKRPASMYER----------------RLVPNVAKGNTDIRNTT 598
            ||.|..:.|.....|| ...|...|..:.:||                |::|.:.: ...:|...
Frog   848 LPHGPPSKGSVVCGND-LGPSAADRTLNKFERLSQSSGTGTTKTALGPRVLPKLPQ-KVALRKID 910

  Fly   599 SMYQMAGDGKPFGEEVKVRS----DLVTR-RLKELIRAMQPVPEDQKQSIAPH--------GELI 650
            :.:.::.|......|:..:|    ||..: ::.:|....||:...||    ||        |||.
Frog   911 TTHHLSMDKYNQQPEIFQKSPQPGDLPQKPQIADLPPKPQPLDIAQK----PHVGDLPPKPGELP 971

  Fly   651 RSAVTDLIALYANLPPNASD-PSRETLKLLTRQNILIQHECE 691
            ..      ....:|||...| |.:..||.|..:..|.:..|:
Frog   972 PK------PQLGDLPPKPQDLPPKPQLKDLPPKPNLAEVMCK 1007

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Git	NP_610599.3	ArfGap	48..164	CDD:279720	39/151 (26%)
		Ank_2	187..279	CDD:289560	24/94 (26%)
		ANK	<187..270	CDD:238125	23/85 (27%)
		ANK repeat	187..213	CDD:293786	12/28 (43%)
		ANK repeat	215..247	CDD:293786	7/31 (23%)
		ANK repeat	249..279	CDD:293786	5/29 (17%)
		GIT_SHD	314..342	CDD:285690	4/27 (15%)
		GIT	374..404	CDD:128828	4/29 (14%)
		GIT1_C	609..727	CDD:289013	24/97 (25%)
asap1	XP_031759002.1	BAR_ASAP1	54..268	CDD:153325
		PH_ASAP	319..425	CDD:270071	2/10 (20%)
		ArfGap_ASAP1	440..561	CDD:350073	40/133 (30%)
		Ank_2	585..660	CDD:403870	19/85 (22%)
		ANK repeat	604..637	CDD:293786	13/43 (30%)
		ANK repeat	639..670	CDD:293786	7/30 (23%)
		PHA03247	<735..1052	CDD:223021	73/369 (20%)
		SH3_ASAP1	1078..1134	CDD:212898
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910