DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Git and appl2

DIOPT Version :9

Sequence 1:	NP_610599.3	Gene:	Git / 36122	FlyBaseID:	FBgn0033539	Length:	731	Species:	Drosophila melanogaster
Sequence 2:	NP_001121547.1	Gene:	appl2 / 100000135	ZFINID:	ZDB-GENE-081016-2	Length:	662	Species:	Danio rerio

Alignment Length:	310	Identity:	57/310 - (18%)
Similarity:	109/310 - (35%)	Gaps:	98/310 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   389 LLTDVLVDAMRRQNMANLRPMDAPVAGH------QSLQSLPYANNSMLLGSFEQGGHDPNLSDDE 447
            ||.:.|.|:.:.:::.::...||....:      ||:|.:..|.|.|.|.: ||      ||...
Zfish     9 LLEEALQDSPQTRSLLSVFEEDAGTLTNYTNQLLQSMQRVFGAQNEMALAT-EQ------LSKQL 66

  Fly   448 PIYD----PVASDDDYAPVPPMAQQAIVHTPPRSANSHNEMETLRKQLNDYKSEINQLKNVVQML 508
            ..|:    .:|..|          :.:::|..:.|.|..|:..|..:|:...::    |.|..|:
Zfish    67 LEYEKQNFALAKGD----------EEVINTLQQFAKSVEELNALHSELSTQIAD----KMVFPMV 117

  Fly   509 S------SENTQLKSKFSSASNNSVYDEPLRIDLSLSSPDTEHEPL-----SLPEGGTANGESGS 562
            .      :|.:.||..||.|::                   |||..     .||:
Zfish   118 QFREKDLTEISTLKEIFSIATD-------------------EHEAAMVKYSRLPK---------- 153

  Fly   563 SNDSSNQSTIKRPASMYERRLVPNVAKGNTDIRNTTSMYQMAGDGKPFGEEV------------- 614
                      ||.....:..:|..||............|..|.:...:.:.|
Zfish   154 ----------KRENEKVKAEVVREVAYSRRKQHQAAMQYYCALNALQYRKRVAMLEPMLGYTHAQ 208

  Fly   615 ----KVRSDLVTRRLKELIRAMQPVPEDQKQSIAPHGELIRSAVTDLIAL 660
                |...:||:::|...:.::..:.|..:..:....|::||:..:|:::
Zfish   209 INFFKKGMELVSKKLDSFLNSVSNMNESIESQLEIDAEVMRSSQRELLSV 258

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Git	NP_610599.3	ArfGap	48..164	CDD:279720
		Ank_2	187..279	CDD:289560
		ANK	<187..270	CDD:238125
		ANK repeat	187..213	CDD:293786
		ANK repeat	215..247	CDD:293786
		ANK repeat	249..279	CDD:293786
		GIT_SHD	314..342	CDD:285690
		GIT	374..404	CDD:128828	4/14 (29%)
		GIT1_C	609..727	CDD:289013	10/69 (14%)
appl2	NP_001121547.1	BAR	21..235	CDD:299863	48/273 (18%)
		BAR-PH_APPL	253..375	CDD:270067	1/6 (17%)
		PH	277..377	CDD:278594
		PTB_APPL	488..614	CDD:269980
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900