Protein Alignment CG11883 and SMN1

DIOPT Version :10

• Sequence 1: NP_001097260.1
• Gene: CG11883 / 36121
• FlyBaseID: FBgn0033538
• Length: 792
• Species: Drosophila melanogaster
• Sequence 2: NP_012072.3
• Gene: SMN1 / 856609
• SGDID: S000001245
• Length: 602
• Species: Saccharomyces cerevisiae
• Alignment Length: 607
• Identity: 110/607 - (18%)
• Similarity: 208/607 - (34%)
• Gaps: 170/607 - (28%)

  Fly   208 MTEGEDKPLTILHYNDVYNIESMAETEPVGGAARFATAIKSFAHLNP------------------ 254
            :...:|.||..:|..|:..|.:   |:..|...         :||:.
Yeast    28 LAPSQDVPLRDIHIGDINFIHT---TDTHGWLG---------SHLSQNDYDADWGDFVAFVDILR 80

  Fly   255 ----------LVLFSGDAFSPSMLS--TFTQGEQMIPVLNTVGTHCAVFGNHDFDHGLDVLVK-- 305
                      :|:.:||....:.||  |:..|.:...:.|.:.......|||:.......:::
Yeast    81 EKILRQSRDVIVIDTGDKRDGNGLSDATWPPGLRSSEIFNMMDYDLLTLGNHELYTAESAILEYR 145

  Fly   306 -LIKQTEF--PWLMSNV---VDNETGRPLGGGKISH---FILHNQISIGLIGLVEREWLETLPTI 361
             ..:.::|  .::.|||   .|:.|..|.|...|:.   .:....:::..:...:|.....:.|.
Yeast   146 GTSQSSKFKDKYVCSNVEFIEDDGTRVPFGNKYITFETPIMKQRVLALSFLFSFQRANNRAIVTP 210

  Fly   362 DPNEVTYIDYVEAGNKLARELRNEGCDLIIALTHM-------RTPNDIN-LAEKC--NGIDIILG 416
            ...|:|...:.:   .:....|.|..||||...|:       |..:.|: |..|.  |.:....|
Yeast   211 PLEEITQKSWFQ---NMVETNREEEIDLIIVFGHLPATDPTEREMHKIHALIRKYYPNTVIQYFG 272

  Fly   417 GHDHVREVTEINGK-MIVKSGTDFQQFSVITIER----DAA-----------NREHFTTDVKCFD 465
            ||.|:|:..:::.| ..::||...:....::|..    ||.           |:|.|...:....
Yeast   273 GHTHIRDFVQLDSKSTCLQSGRFAETVGFLSINMTDPVDAESPIFSRRYIDFNKEAFKYHLSKLG 337

  Fly   466 VTAKIPEDP-----------ELKQELSKYAKFIESKLSDVMGVFSVELDGRFSRVRTQETNLGNW 519
            ..:.:|...           :|:.||:     :..||..:...:.|.     :|....|.||.:.
Yeast   338 HDSNVPVSTKKGKTISRLVNDLRHELN-----LNEKLGYIPQTYYVS-----TRPLNSEENLYHL 392

  Fly   520 VCDVVLAAV---------GADVVILNGGTFRSDRVHPVGAFTMGDLVNVIPMRD-------PLIL 568
            :...:|..:         .:..:::|.|:.|.|...  |.||......|:|..:       ||::
Yeast   393 ITHKILPNLIPPKNYEPSMSRFILINTGSVRYDLYK--GPFTKDTEYIVMPFNNDWRFITVPLVV 455

  Fly   569 ---LEV---KGKILWQALENGVSAYPKLEGRFPQVSGISFAFDPQAEPGKRIDPQLIQVGDEY-L 626
               :|.   ||.::   ...|:.:....:..|.......|..:|....|...:......||:. .
Yeast   456 ASRVETYLNKGPVI---ASLGIPSSSHHKQHFGGFQKCPFINNPNLSEGYTTEDDFGCHGDDTPH 517

  Fly   627 NLEQSYKL-----C--VKS----------------YIFMGCDGYTMFKDATVLMDDDACPELGIT 668
            |.::.|.:     |  ||.                |.||..|   :......:::|     ||:.
Yeast   518 NSQREYDIPNVVQCKEVKKVQEEEADPSKMVHVIFYSFMELD---ILNAVNSIIND-----LGLR 574

  Fly   669 LQNHFKAINSRKC----GQNTK 686
            ::|    :.:..|    |.:||
Yeast   575 MEN----LTTNDCSHYGGDSTK 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11883	NP_001097260.1	MPP_CG11883_N	216..473	CDD:277351	59/323 (18%)
		5_nucleotid_C	494..652	CDD:427027	36/203 (18%)
SMN1	NP_012072.3	MPP_YHR202W_N	39..325	CDD:277352	54/300 (18%)