DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11883 and Nt5el

DIOPT Version :9

Sequence 1:	NP_001097260.1	Gene:	CG11883 / 36121	FlyBaseID:	FBgn0033538	Length:	792	Species:	Drosophila melanogaster
Sequence 2:	NP_080027.1	Gene:	Nt5el / 66763	MGIID:	1914013	Length:	585	Species:	Mus musculus

Alignment Length:	603	Identity:	244/603 - (40%)
Similarity:	353/603 - (58%)	Gaps:	56/603 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   203 KKLLKMTEG------EDKPLTILHYNDVYNIESMAETEPVGGAARFATAIKSFAHLNPLVLFSGD 261
            ::|...|:|      :...|||||:||||:::|..| ||||||||||||:|.|:.||||::||||
Mouse    21 EELSPQTQGNQSGDMDSYNLTILHFNDVYDVDSSTE-EPVGGAARFATAVKRFSILNPLLIFSGD 84

  Fly   262 AFSPSMLSTFTQGEQMIPVLNTVGTHCAVFGNHDFDHGLDVLVKLIKQTEFPWLMSNVVDNETGR 326
            ..:||:|||.|:|:.||.:||.:|.|.||||||:||.|:|:|.:.:||..|.|.:|||.|..|..
Mouse    85 CLNPSILSTITKGKHMISILNELGVHFAVFGNHEFDFGVDILEEYMKQMHFTWFLSNVHDRFTSE 149

  Fly   327 PLGGGKISHFILHNQISIGLIGLVEREWLETLPTIDPNEVTYIDYVEAGNKLARELRNEGCDLII 391
            |||.|.:...:..|...|||:||||.:||:||.|::...|.|.||||..|:||.|||.||.||:|
Mouse   150 PLGHGAVKKIVNWNNRKIGLMGLVEEDWLDTLATVNKANVNYKDYVETANELAVELRAEGADLVI 214

  Fly   392 ALTHMRTPNDINLAEKCNGIDIILGGHDHVREVTEINGKMIVKSGTDFQQFSVITIERDAANREH 456
            |:|||:..||..||:...|:|:|||||||...:.::|...|||||:||:..:.|.|:...|:.::
Mouse   215 AMTHMKWKNDTRLAQHAEGLDLILGGHDHEYGIKKVNETWIVKSGSDFKNLTKIDIQLFDASFQY 279

  Fly   457 FTTDVKCFDVTAKIPEDPELKQELSKYAKFIESKLSDVMGVFSVELDGRFSRVRTQETNLGNWVC 521
            ....|   ::.:.:.||..:|..:..:.:.|:..|.:|:....|.||||...||..|:||||.|.
Mouse   280 VFEKV---EILSYLEEDSYIKAIVRDFTQNIQYMLEEVLCPIDVALDGREITVRRCESNLGNLVT 341

  Fly   522 DVVLAAVGADVVILNGGTFRSDRVHPVGAFTMGDLVNVIPMRDPLILLEVKGKILWQALENGVSA 586
            :.:|.|..|||.:||.||.|.||:||.|.||:.||:.::|:.||::::...|..|.:||||||..
Mouse   342 NAMLEATHADVALLNSGTLRYDRIHPPGNFTLHDLLAILPIVDPVLVVRATGAQLLEALENGVYK 406

  Fly   587 YPKLEGRFPQVSGISFAFDPQAEPGKRIDPQLIQVGDEYLNLEQSYKLCVKSYIFMGCDGYTMFK 651
            ||.|:||||||:|:.|.|||.||||.|:....::|..:||..::.|.|.:|.||..|.|||:||:
Mouse   407 YPALDGRFPQVAGLEFGFDPDAEPGHRVIRDTVKVQGQYLQRKKVYLLAIKEYIANGKDGYSMFR 471

  Fly   652 DATVLMDDDACPELGITLQNHFKAI----NSRKCGQNTKHRQSLVTLSRRHSLVQCLDSMDLDGP 712
            ....:.|.:....|...:.|||::|    ..:||  .:.||.||:|.:.:...:...:. :.|||
Mouse   472 ACPRMFDPETAQVLSTVVMNHFESIKILQGKKKC--LSGHRMSLITTTNKSPSLTAFEE-ETDGP 533

  Fly   713 SPIRKLSVGHHNKSMDLTHGNSQKMLRRASLDDLEQSTCDLAPQLEHRIVMIQNE--EHHRQLLF 775
            ..:  ::|                                  |.||.||..|..:  ||..||..
Mouse   534 LGV--IAV----------------------------------PGLEGRIFHISPDMKEHLHQLRA 562

  Fly   776 KKETHIMN-STITEAEDE 792
            .::..:.. .||:::..|
Mouse   563 ARQQGLRTFPTISDSARE 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11883	NP_001097260.1	UshA	202..661	CDD:223808	215/463 (46%)
		MPP_CG11883_N	216..473	CDD:277351	129/256 (50%)
		5_nucleotid_C	494..646	CDD:280945	72/151 (48%)
Nt5el	NP_080027.1	nadN	40..470	CDD:211667	209/433 (48%)
		MPP_CG11883_N	40..293	CDD:277351	129/256 (50%)
		5_nucleotid_C	328..466	CDD:280945	66/137 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849151
Domainoid	1	1.000	245	1.000	Domainoid score	I2185
eggNOG	1	0.900	-	-		E1_COG0737
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12028
Inparanoid	1	1.050	438	1.000	Inparanoid score	I1660
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58636
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001036
OrthoInspector	1	1.000	-	-		oto92901
orthoMCL	1	0.900	-	-		OOG6_103434
Panther	1	1.100	-	-	LDO	PTHR11575
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4862
SonicParanoid	1	1.000	-	-		X13172
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790