DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment psq and bab2

DIOPT Version :9

Sequence 1:	NP_001369078.1	Gene:	psq / 36118	FlyBaseID:	FBgn0263102	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_523879.2	Gene:	bab2 / 44254	FlyBaseID:	FBgn0025525	Length:	1067	Species:	Drosophila melanogaster

Alignment Length:	1276	Identity:	272/1276 - (21%)
Similarity:	397/1276 - (31%)	Gaps:	531/1276 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 QYFSLRWNNYQNTMTSVFQQLREDLSFVDVTLSCEHGSLKAHKVVLSACSTYFQKLLLENPCKHP 72
            |.|.|||||||:.:|:||.:|.:..||||||||||..|:||||:||||||.|||.|..:|||:||
  Fly   196 QQFCLRWNNYQSNLTNVFDELLQSESFVDVTLSCEGHSIKAHKMVLSACSPYFQALFYDNPCQHP 260

  Fly    73 TIILPADIIFTDLKTIIDFVYRGEIDVTESELQGLLRTAEQLKIKGLCETAENADDLNDAATATI 137
            .||: .|:.::|||.:::|:|:|||:|.:.::..||:.||.|||:||.|
  Fly   261 IIIM-RDVSWSDLKALVEFMYKGEINVCQDQINPLLKVAETLKIRGLAE---------------- 308

  Fly   138 TVSENIQQAVVGNIVNAAIVPGAPSPSLEQQQQHHQQQQQQQAQEQHQQQQVHAQQQQQQQQQIN 202
                          |:|....|..| :|.......:.::::.|......||.......::.:...
  Fly   309 --------------VSAGRGEGGAS-ALPMSAFDDEDEEEELASATAILQQDGDADPDEEMKAKR 358

  Fly   203 AALLTQHGVSSGSVSLSGQLLSSSASGS----SGSLAGGQQASQTPSGLQPTPRKSRLKRSKSPD 263
            ..||.:     |.:.|:.:....|..||    |.||.||:.                       :
  Fly   359 PRLLPE-----GVLDLNQRQRKRSRDGSYATPSPSLQGGES-----------------------E 395

  Fly   264 LSSGGGAGSSGGSSSGSTQQQP----------QPAHHHHPQTILIQGQNP--NSIVSLQQTADGN 316
            :|..|.:|:.|.|     |.||          .|....:|||  ::|:|.  |::.:.:::.
  Fly   396 ISERGSSGTPGQS-----QSQPLAMTTSTIVRNPFASPNPQT--LEGRNSAMNAVANQRKSP--- 450

  Fly   317 YIPVSGSGDDSDAEDHEHEHNHGHGHGHGGHTHGHGHSHEHSHDHEHEHKPNKICKTEHSVASPA 381
             .|.:                       .||::|
  Fly   451 -APTA-----------------------TGHSNG------------------------------- 460

  Fly   382 SNSSSASNNAAGVSGVTSTGQAIVTQIVVARDGKDTKNMTSLGMGMNGGLLGVPMGFLDFTPEPP 446
             ||.:|.::..|...|.|.....:..||                                   ||
  Fly   461 -NSGAAMHSPPGGVAVQSALPPHMAAIV-----------------------------------PP 489

  Fly   447 APSATPVTVTEHVDLSCNPSTDTRDLSNTTEPLDIDNHLAQQIHRLDQSPMHSISHHHTGDESNS 511
            .|||                                                  .|||
  Fly   490 PPSA--------------------------------------------------MHHH------- 497

  Fly   512 NLVQHIKSEVIEAKHLAAQHHALSQAQQQHAHHQAHQQHQQHQQQQHQQQQQHLHAQQLLAQSQL 576
                        |:.|||||        |.||                   .|..|..|.|.:
  Fly   498 ------------AQQLAAQH--------QLAH-------------------SHAMASALAAAA-- 521

  Fly   577 QQQQQQQQQQQQHHQQQQQQAAAAAAAAGVHGQHGGHVTHADIGGATVMEIDPSQI--KHEPGMI 639
                                |.|.||.||..|...|....|..||..|........  .|...|.
  Fly   522 --------------------AGAGAAGAGGAGSGSGSGASAPTGGTGVAGSGAGAAVGSHHDDME 566

  Fly   640 ITPEIVNMMSSGHMDMYNSDTSEDSMMIANGSPHDQKEPHYTNLDQQHGLGGSVCGPGPGGAGGG 704
            |.|||..|:..          .|.:.||.                                :||.
  Fly   567 IKPEIAEMIRE----------EERAKMIE--------------------------------SGGH 589

  Fly   705 GGMSGGAGSGSGEKALDALKNQNMSLTKASAIYGIPSTTLWQRAHRMGIETP------KKEGGTK 763
            ||..|.|.:.:|..::            |:..|.....::||:......:..      ::.|..|
  Fly   590 GGWMGAAAAATGAASV------------AADSYQYQLQSMWQKCWNTNQQNLVQQLRFRERGPLK 642

  Fly   764 SWNEDALQNALEALRSGQISANKASKAFGIPSSTLYKIARREGIRLAAPFNAAPTTWTPEDLERA 828
            ||..:|:..|:.::....:|.::|::.|.||..|....|.|....|.
  Fly   643 SWRPEAMAEAIFSVLKEGLSLSQAARKFDIPYPTFVLYANRVHNMLG------------------ 689

  Fly   829 LEAIRAGNTSVQKASAEFGIPTGTLYGRCKREGIELSRSNPTPWSEDAMNEALNSVRVGQMSINQ 893
             .::..|.....||.   |.|...|.|.               |.|:.:...:.:|
  Fly   690 -PSLDGGADPRPKAR---GRPQRILLGM---------------WPEELIRSVIKAV--------- 726

  Fly   894 AAIHYNLPYSSLYGRFKRGKYDV----VANTSGVALLNTSGNTTG---SIEIIEHSQENSQQFPY 951
                       ::..::..|.|:    .||..|.......|.||.   |....:.:.:|:...|
  Fly   727 -----------VFRDYREIKEDMSAHQYANGQGHGTYIGGGTTTNGYHSAAAAKLAAQNAALAP- 779

  Fly   952 SPSPHPPTPQHHSTPQHHSSAQQGPPTPQHMQQH--VVHMQQQQQQQQQQSPHPG-----HHPQH 1009
             |....|......|.:....:||    .||.|.|  ..|.|||....||||||..     ..|.:
  Fly   780 -PDAGSPLSSMTETLRRQILSQQ----QQHQQHHQQQAHHQQQPSHHQQQSPHAQSMNMYKSPAY 839

  Fly  1010 MQ----QDVVTSSSQVV-----HSQQQQQLQQIYQHHGTPERSXES---LHAATLMGSTG----- 1057
            :|    :|.|::::.|.     |.|||.:           .|..|:   |.|..|||..|
  Fly   840 LQRSEIEDQVSAAAAVAAAAAKHQQQQGE-----------RRGSENLPDLSALGLMGLPGLNVMP 893

  Fly  1058 -GGGGGGVGGVA-------------------------------ASTSDGTAASSTPFASISALVS 1090
             .|.|||.||.|                               .|.|.|:::.|....|::|  |
  Fly   894 SRGSGGGSGGAAPNSAASYARELSRERERDRERERERELSRQYGSQSRGSSSGSGSAKSLTA--S 956

  Fly  1091 GPSSAPPPPVTASGSSAVSGGTSKR--------------------KKANKQKRXEQEDDQPHREL 1135
            ....|..|...|..:...:...:||                    |..||..|.|.....|.:::
  Fly   957 QRPGAASPYSAAHYAKHQASAYNKRFLESLPAGIDLEAFANGLLQKSVNKSPRFEDFFPGPGQDM 1021

  Fly  1136 ETI------------AGVARPEDIKFRFNCKHWKRKLRQFH 1164
            ..:            |..|.|..|:   .....|.||.|.|
  Fly  1022 SELFANPDASAAAAAAAYAPPGAIR---ESPLMKIKLEQQH 1059

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
psq	NP_001369078.1	BTB_POZ_BAB-like	34..118	CDD:349624	48/83 (58%)
		HTH_psq	717..>747	CDD:283007	3/29 (10%)
		HTH_psq	767..804	CDD:283007	9/36 (25%)
		HTH_psq	821..866	CDD:283007	7/44 (16%)
		HTH_psq	873..916	CDD:283007	3/42 (7%)
bab2	NP_523879.2	BTB	213..309	CDD:279045	54/126 (43%)
		BTB	224..309	CDD:197585	49/115 (43%)
		HTH_psq	645..690	CDD:283007	11/63 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10615
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	73	1.000	Inparanoid score	I5272
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	4.150