DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17765 and CAPN8

DIOPT Version :9

Sequence 1:	NP_610592.1	Gene:	CG17765 / 36111	FlyBaseID:	FBgn0033529	Length:	199	Species:	Drosophila melanogaster
Sequence 2:	NP_001137434.1	Gene:	CAPN8 / 388743	HGNCID:	1485	Length:	703	Species:	Homo sapiens

Alignment Length:	192	Identity:	40/192 - (20%)
Similarity:	89/192 - (46%)	Gaps:	27/192 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GGGYAPPPGAFPPQNAQVSPQAQQWFSMVDR--DRSGKINASELQAAL-------VNGRGDHFSD 69
            |..|.|.|       ::|..:..|:..:.::  .:..:|.|:.|:..|       .:.:.|.|:.
Human   520 GNPYEPHP-------SEVDQEDDQFRRLFEKLAGKDSEITANALKILLNEAFSKRTDIKFDGFNI 577

  Fly    70 NACKLMISMFDNDASGTIDIYEFEKLYNYINQWLQVFKTYDQDSSGHIEEQELTQAFTQMGFRFS 134
            |.|:.|||:.|::.:||:...||:.|:..|.::|:::...|.:.||.|:..|:..|..:.||..:
Human   578 NTCREMISLLDSNGTGTLGAVEFKTLWLKIQKYLEIYWETDYNHSGTIDAHEMRTALRKAGFTLN 642

  Fly   135 PEF-----INFLVKKSDPQGHKEVSVDQFIVLCVQVQRFTEAFRQRDTQQNGTITIGFEDFL 191
            .:.     :.:...|..      ::.|.|:...::::...:.|...|..::|.:.:...::|
Human   643 SQVQQTIALRYACSKLG------INFDSFVACMIRLETLFKLFSLLDEDKDGMVQLSLAEWL 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17765	NP_610592.1	FRQ1	26..162	CDD:227455	32/149 (21%)
		EFh	39..92	CDD:238008	14/61 (23%)
		EFh	105..159	CDD:298682	10/58 (17%)
CAPN8	NP_001137434.1	Peptidase_C2	46..342	CDD:279042
		Calpain_III	356..509	CDD:279416
		Domain III	356..379
		EFh	580..635	CDD:238008	18/54 (33%)
		PTZ00183	618..>692	CDD:185503	14/79 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146563
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840