Protein Alignment whd and Cpt1c

DIOPT Version :10

• Sequence 1: NP_001163111.1
• Gene: whd / 36109
• FlyBaseID: FBgn0261862
• Length: 782
• Species: Drosophila melanogaster
• Sequence 2: NP_001344599.1
• Gene: Cpt1c / 78070
• MGIID: 2446526
• Length: 799
• Species: Mus musculus
• Alignment Length: 782
• Identity: 329/782 - (42%)
• Similarity: 466/782 - (59%)
• Gaps: 29/782 - (3%)

  Fly     1 MAEAHAAVAFSFAITHEGFDINYDHEVLNLVWNSGVRSWKKRLARARNGVRNGVYPA-HIQSLWL 64
            |||||.|.:...:::.:|.::.....|...::...:||||:.|.|..|....||.|| .:..|:|
Mouse     1 MAEAHQASSLLSSLSSDGAEVELSSPVWQEIYLCALRSWKRHLWRVWNDFLAGVVPATPLSWLFL 65

  Fly    65 ISAIALGLHFAGYQAPFNLTNRILVHLPSNTINW-----QVTACFLAALV----VWLSICFTMRY 120
            .|.|.|.. .........|..:|...||    :|     |:.. ||:|.|    :|.::.||:..
Mouse    66 FSTIQLAC-LLQLDPSLGLMEKIKELLP----DWGGQHHQLQG-FLSAAVFASCLWGALIFTLHV 124

  Fly   121 TLKLLLMYKGWMYESRAPGSRVSLPTMLWVAVVRVLSSWNKPGLYSFQGSLPRLPLPSVKDTMTR 185
            .|:|||.:.||:.|   |...:|.||..|:|:||:.|. ..|.|:|||.:|||.|:||.::|:.:
Mouse   125 ALRLLLSHHGWLLE---PHGAMSSPTKTWLALVRIFSG-RHPRLFSFQRALPRQPVPSAQETVRK 185

  Fly   186 YLRSVRPLLDDENYTRMERLAKEFEQTIGKKLQWYLILKSWWSTNYVSDWWEEYVYLRGRSPLCV 250
            ||.||||:|.|:.:.|...||.:|.:....:||.||.||||.::|||||||||:||||.|..| :
Mouse   186 YLESVRPVLGDDAFDRATALANDFLRLHAPRLQLYLQLKSWCTSNYVSDWWEEFVYLRSRGSL-I 249

  Fly   251 NSNFY-GTDAIFMNLTDKQAARAANVISLLLNFRRLIEHQELQPIMVQGMIPLCSWQYERTFNTA 314
            ||.:| ..|.:::..|..|||||.|.:..||.:|.|:..||:.|.::.||.||||.||||.|||.
Mouse   250 NSTYYMMQDFLYVTPTPLQAARAGNAVHTLLLYRHLLNRQEISPTLLMGMRPLCSAQYERMFNTT 314

  Fly   315 RVPGLETDRIIHYRDSNHIVVLHKGCYYKMLIYYKGRILRPCELQVQIEEILKGKATPVEGEEHL 379
            |:||:|.|.:.|.:||.|:.|.|:|.::::..:....:|.|..|:.|.::||...:.....||||
Mouse   315 RIPGVEKDHLRHLQDSRHVAVFHRGRFFRVGTHSPNGLLSPRALEQQFQDILDDPSPACPLEEHL 379

  Fly   380 AALTAWNRSKWAEARNTFFSWGVNQTSLRTIESAAFVLSLDDEPFEFDLARPEL-LDNFGKKLLH 443
            |||||..||.||:.|.:..:...  |:|..:|.|||.:|||.||.......|.. ||.:...||.
Mouse   380 AALTAAPRSMWAQVRESVKTHAA--TALEAVEGAAFFVSLDSEPAGLTREDPAASLDAYAHALLA 442

  Fly   444 GNGYNRWFDKCFTVCVGTNGRVGFNAEHTWSDAAIASHMWENLIVDDLVSDGYDETGNTKGTPAF 508
            |.|::|||||.||:.|.:||::|.:.||:|:|..::.|:||..:..:....||...|:.||.|..
Mouse   443 GRGHDRWFDKSFTLIVFSNGKLGLSVEHSWADCPVSGHLWEFTLATECFQLGYATDGHCKGHPDP 507

  Fly   509 QPPTPTRLTWDL-KPCLAQIEEATIDVTKLINEVNLRILVHQDYGKGFMKKCRISPDAYIQMALQ 572
            ..|.|.||.||| :.....|..|......|...::..:.....:||.|:|.|.:|.|::||:.||
Mouse   508 TLPQPQRLQWDLPEQIQPSISLALRGAKTLSGNIDCHVFPFSHFGKSFIKCCHVSSDSFIQLVLQ 572

  Fly   573 LAYYRDAGRFSLTYEASMTRLFREGRTETVRPCTIESSAWVKAMQNPNTTNDERVKMMQAACDRH 637
            ||::||.|:|.||||::|||||.||||||||.||.|:..:|:||.| ..|:...:.:.:.|.|:|
Mouse   573 LAHFRDRGQFCLTYESAMTRLFLEGRTETVRSCTREACQFVRAMDN-KETDQHCLALFRVAVDKH 636

  Fly   638 QLGYQDAMCGRGIDRHLFCLYVVSKYLEVDSPFLNEVLSEPWRLSTSQTPHGQTPKMDLKKHPNC 702
            |...:.||.|:|||||||.||::|:.|.:.||||.:|.|:.|.|||||.|..||..:|:..:|:.
Mouse   637 QALLKAAMSGQGIDRHLFALYIMSRLLHMQSPFLTQVQSQQWLLSTSQVPVQQTHLIDVHNYPDY 701

  Fly   703 ISAGGGFGPVADDGYGVSYIIAGENLIFFHISAKTTCQQTDVHRFAQNISQALSDIRSMFE--QH 765
            :|:||||||..|.|||:|||..|||.|.||||:|.:..:||.||..|:|..||.|:.|:|.  ||
Mouse   702 VSSGGGFGPAHDHGYGISYIFMGENAITFHISSKKSSTETDSHRLGQHIENALLDVASLFRVGQH 766

  Fly   766 MK 767
            .|
Mouse   767 FK 768

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
whd	NP_001163111.1	CPT_N	1..47	CDD:465132	14/45 (31%)
		Carn_acyltransf	174..753	CDD:459926	260/581 (45%)
Cpt1c	NP_001344599.1	CPT_N	1..47	CDD:465132	14/45 (31%)
		Carn_acyltransf	174..751	CDD:459926	259/580 (45%)
		Required for interaction with GRIA1. /evidence=ECO:0000269|PubMed:32931550	760..799		4/9 (44%)