DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment whd and cpt1ab

DIOPT Version :9

Sequence 1:	NP_001163111.1	Gene:	whd / 36109	FlyBaseID:	FBgn0261862	Length:	782	Species:	Drosophila melanogaster
Sequence 2:	XP_005170764.1	Gene:	cpt1ab / 560000	ZFINID:	ZDB-GENE-030131-3250	Length:	775	Species:	Danio rerio

Alignment Length:	787	Identity:	398/787 - (50%)
Similarity:	528/787 - (67%)	Gaps:	28/787 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAEAHAAVAFSFAITHEGFDINYDHEVLNLVWNSGVRSWKKRLARARNGVRNGVYPAHIQSLWLI 65
            |||||.||||.|.:|.:|.|::..||.|..::.||:.|||||..|.:|||..||||.....|.::
Zfish     1 MAEAHQAVAFQFTVTPDGIDLHLCHEALRQIYLSGIHSWKKRFIRFKNGVMTGVYPGSPSGLVVV 65

  Fly    66 SAIALGLHFAGYQA---------PFNLTNRILVHLPSNTI----NWQVTACFLAALVVWLSICFT 117
                    ..||.:         ...:..::..|||.:..    ..::....|....:|:::.|.
Zfish    66 --------LVGYMSSTKYAKIDPSLGILTKLSTHLPVSKYITEDGQRIVGGVLVGTGLWIAVTFV 122

  Fly   118 MRYTLKLLLMYKGWMYESRAPGSRVSLPTMLWVAVVRVLSSWNKPGLYSFQGSLPRLPLPSVKDT 182
            ||..||.||.:.|||:...   ..:||.|.:|:.:|::.|. .||.|||||.||||||:|.||||
Zfish   123 MRNALKYLLSWHGWMFNQH---GTLSLKTKIWLVLVKLFSG-PKPMLYSFQSSLPRLPVPPVKDT 183

  Fly   183 MTRYLRSVRPLLDDENYTRMERLAKEFEQTIGKKLQWYLILKSWWSTNYVSDWWEEYVYLRGRSP 247
            :.|||.|.|||:|||.|.|||.|||:||:.:|.||||||.|||||::||||||||||:|||||||
Zfish   184 VRRYLESARPLMDDEQYKRMEGLAKDFEKNLGPKLQWYLKLKSWWTSNYVSDWWEEYIYLRGRSP 248

  Fly   248 LCVNSNFYGTDAIFMNLTDKQAARAANVISLLLNFRRLIEHQELQPI-MVQGMIPLCSWQYERTF 311
            :.||||:|..|.:::|.|..|||||.|.|..::.:||.::..:::|: :::..:||||.|:||.|
Zfish   249 IMVNSNYYAMDFLYVNPTSLQAARAGNSIHAMMMYRRKLDRAQIKPLYLLENRVPLCSAQWERMF 313

  Fly   312 NTARVPGLETDRIIHYRDSNHIVVLHKGCYYKMLIYYKGRILRPCELQVQIEEILKGKATPVEGE 376
            ||.|:||||||.:.|..:|.||.|.|||.:||:.::|.||:|.|.|::.|:|.||..|:.|..||
Zfish   314 NTCRIPGLETDVLQHVNESKHIAVYHKGRFYKVWMFYDGRLLLPREIEQQMERILADKSEPQPGE 378

  Fly   377 EHLAALTAWNRSKWAEARNTFFSWGVNQTSLRTIESAAFVLSLDDEPFEFDLARP-ELLDNFGKK 440
            |.||||||.:|..||:||:.||..|.|:.||..:|.|||.::|||....::...| :.||::||.
Zfish   379 EFLAALTAGDRVPWAKARSQFFIRGKNKQSLDAVEKAAFFVTLDDSEQRYEPDNPIQSLDSYGKS 443

  Fly   441 LLHGNGYNRWFDKCFTVCVGTNGRVGFNAEHTWSDAAIASHMWENLIVDDLVSDGYDETGNTKGT 505
            ||||..|:|||||...:.|..||.:|.||||:|:||.|..|:||.::..|.|..||.|.|:.||.
Zfish   444 LLHGKCYDRWFDKSLNLIVFKNGTMGLNAEHSWADAPIVGHLWEQVLSSDPVRLGYTEEGHCKGN 508

  Fly   506 PAFQPPTPTRLTWDL-KPCLAQIEEATIDVTKLINEVNLRILVHQDYGKGFMKKCRISPDAYIQM 569
            |....|.|.||.||: :.|...|..:......|.::|::.|....|:|||.:|||:.|||.:||:
Zfish   509 PHPNMPGPQRLQWDIPEECQTVISSSLKVANTLADDVDMHIFPFNDFGKGLIKKCKTSPDGFIQL 573

  Fly   570 ALQLAYYRDAGRFSLTYEASMTRLFREGRTETVRPCTIESSAWVKAMQNPNTTNDERVKMMQAAC 634
            |||||::||.|:|.||||||||||||||||||||.||.|:.|:|.||.:...|.:||:|:::||.
Zfish   574 ALQLAHFRDKGKFCLTYEASMTRLFREGRTETVRSCTNETCAFVHAMMDEKATREERLKLLKAAT 638

  Fly   635 DRHQLGYQDAMCGRGIDRHLFCLYVVSKYLEVDSPFLNEVLSEPWRLSTSQTPHGQTPKMDLKKH 699
            ::||..|:.||.|:||||||||||:|||||..|||||.|||||||||||||||..|....|||||
Zfish   639 EKHQNLYKLAMTGKGIDRHLFCLYLVSKYLGEDSPFLKEVLSEPWRLSTSQTPLQQMELFDLKKH 703

  Fly   700 PNCISAGGGFGPVADDGYGVSYIIAGENLIFFHISAKTTCQQTDVHRFAQNISQALSDIRSMFEQ 764
            |..:::||||||||||||||||||.||:||.||||:|.:..:||.|||..||.||:.||..:|:.
Zfish   704 PEYVTSGGGFGPVADDGYGVSYIILGEDLINFHISSKHSSHETDSHRFGSNIKQAMLDILDLFQL 768

  Fly   765 HMKDHPK 771
            .:|.:.|
Zfish   769 DIKPNKK 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
whd	NP_001163111.1	CPT_N	1..45	CDD:293093	23/43 (53%)
whd	NP_001163111.1	Carn_acyltransf	171..759	CDD:279140	331/590 (56%)
cpt1ab	XP_005170764.1	CPT_N	1..46	CDD:293093	23/44 (52%)
cpt1ab	XP_005170764.1	Carn_acyltransf	172..762	CDD:279140	330/589 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581471
Domainoid	1	1.000	689	1.000	Domainoid score	I130
eggNOG	1	0.900	-	-		E1_KOG3716
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	802	1.000	Inparanoid score	I475
OMA	1	1.010	-	-		QHG56619
OrthoDB	1	1.010	-	-		D228690at33208
OrthoFinder	1	1.000	-	-		FOG0002000
OrthoInspector	1	1.000	-	-		otm24464
orthoMCL	1	0.900	-	-		OOG6_102071
Panther	1	1.100	-	-	LDO	PTHR22589
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4374
SonicParanoid	1	1.000	-	-		X480
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800