DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment whd and cpt1b

DIOPT Version :9

Sequence 1:	NP_001163111.1	Gene:	whd / 36109	FlyBaseID:	FBgn0261862	Length:	782	Species:	Drosophila melanogaster
Sequence 2:	NP_001315121.1	Gene:	cpt1b / 449677	ZFINID:	ZDB-GENE-041010-9	Length:	770	Species:	Danio rerio

Alignment Length:	773	Identity:	399/773 - (51%)
Similarity:	523/773 - (67%)	Gaps:	11/773 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAEAHAAVAFSFAITHEGFDINYDHEVLNLVWNSGVRSWKKRLARARNGVRNGVYPAHIQSLWLI 65
            |||||.||||.|.:|.:|.|:....|||..::.|||.|||||..|.:|.|..|||||. .|.||.
Zfish     1 MAEAHQAVAFQFTVTPDGIDLQLSREVLKHIYISGVTSWKKRAIRFKNSVLTGVYPAS-PSSWLF 64

  Fly    66 SAIA-LGLHFAGYQAPFNLTNRILVHLPSN---TINWQ-VTACFLAALVVWLSICFTMRYTLKLL 125
            ..|| :...:|.........::|...||.:   |:..| |.:..|.|..:|||:.|.:||.||.|
Zfish    65 VVIAIMSTMYARIDPSMGTIDKIKTSLPVSEFMTVQTQTVLSAILFATGLWLSVIFLLRYLLKAL 129

  Fly   126 LMYKGWMYESRAPGSRVSLPTMLWVAVVRVLSSWNKPGLYSFQGSLPRLPLPSVKDTMTRYLRSV 190
            |.|..|::||.   .::|..|.:|:::|::||. .:|.|||||||||.||:||:.||:.|||.||
Zfish   130 LSYHAWIFESH---GKMSYSTKVWLSLVKLLSG-RRPLLYSFQGSLPHLPVPSIDDTIRRYLESV 190

  Fly   191 RPLLDDENYTRMERLAKEFEQTIGKKLQWYLILKSWWSTNYVSDWWEEYVYLRGRSPLCVNSNFY 255
            |||||||.|.:||.:|.:|::....|||.:|.|||||:|||||||||||:|||||.|:.||||||
Zfish   191 RPLLDDEQYKQMETVANDFKKDPAPKLQKHLKLKSWWATNYVSDWWEEYIYLRGRDPIMVNSNFY 255

  Fly   256 GTDAIFMNLTDKQAARAANVISLLLNFRRLIEHQELQPIMVQGMIPLCSWQYERTFNTARVPGLE 320
            ..|.:::..|.:|||||.||:..:|.:||.:|..||.|:...|::|:||:||||.|||.|:||:|
Zfish   256 TMDLLYVIPTYRQAARAGNVVHAMLQYRRKLERGELTPLRALGIVPMCSFQYERMFNTTRIPGIE 320

  Fly   321 TDRIIHYRDSNHIVVLHKGCYYKMLIYYKGRILRPCELQVQIEEILKGKATPVEGEEHLAALTAW 385
            ||.:.|.:|..|:||.|:|..:|:.:||.||.|.|.||::|.:.||..|:.|..||..|.:|||.
Zfish   321 TDFVQHLKDRKHLVVYHRGRLFKVWLYYGGRHLWPSELELQFQRILDDKSEPQPGELKLPSLTAG 385

  Fly   386 NRSKWAEARNTFFSWGVNQTSLRTIESAAFVLSLDDEPFEFDLARPELLDNFGKKLLHGNGYNRW 450
            ||..||.||..:|..|||:.||..||:|||.|:||||...:|......||.:.|.||||..|:||
Zfish   386 NRVPWARARLKYFGEGVNRASLEAIETAAFFLTLDDEAHGYDPENIRSLDLYAKSLLHGKCYDRW 450

  Fly   451 FDKCFTVCVGTNGRVGFNAEHTWSDAAIASHMWENLIVDDLVSDGYDETGNTKGTPAFQPPTPTR 515
            |||.|.:.|..||::|.|.||:|:|:.|..||||.::..|....||...|:.||........|||
Zfish   451 FDKSFNLIVYKNGKMGVNTEHSWADSPIIGHMWEYVLATDCFHLGYTAEGHCKGDVNKTLAPPTR 515

  Fly   516 LTWDLKPCLAQIEEATIDVTK-LINEVNLRILVHQDYGKGFMKKCRISPDAYIQMALQLAYYRDA 579
            |.||:.....:|.|.:..:.| :.::|:....:..::|||.:||||.||||:||:|||||.|||.
Zfish   516 LQWDIPKACQEIIEGSYRIAKGIADDVDFHGCLFNEFGKGLIKKCRTSPDAFIQLALQLAQYRDK 580

  Fly   580 GRFSLTYEASMTRLFREGRTETVRPCTIESSAWVKAMQNPNTTNDERVKMMQAACDRHQLGYQDA 644
            |.|.||||:||||:||||||||||.||.||:|:|:||::..|||::|:.:.:.|.::||..|:.|
Zfish   581 GEFCLTYESSMTRMFREGRTETVRSCTCESTAFVRAMEDDTTTNEQRLALFKQAAEKHQNMYRLA 645

  Fly   645 MCGRGIDRHLFCLYVVSKYLEVDSPFLNEVLSEPWRLSTSQTPHGQTPKMDLKKHPNCISAGGGF 709
            |.|.||||||||||:|||.:.:|||||.:||||||||||||||..|...:|.:|.|..:||||||
Zfish   646 MTGAGIDRHLFCLYIVSKVMGIDSPFLKQVLSEPWRLSTSQTPQQQLNLIDTQKFPKYVSAGGGF 710

  Fly   710 GPVADDGYGVSYIIAGENLIFFHISAKTTCQQTDVHRFAQNISQALSDIRSMFEQHMK 767
            ||||||||||||||.|||||.||||:|.:..:||..||.|||.||:.|||::|.|..|
Zfish   711 GPVADDGYGVSYIIVGENLITFHISSKFSSPETDSFRFGQNIRQAMQDIRALFNQKEK 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
whd	NP_001163111.1	CPT_N	1..45	CDD:293093	24/43 (56%)
whd	NP_001163111.1	Carn_acyltransf	171..759	CDD:279140	320/588 (54%)
cpt1b	NP_001315121.1	CPT_N	1..46	CDD:293093	24/44 (55%)
cpt1b	NP_001315121.1	Carn_acyltransf	171..760	CDD:279140	320/588 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581470
Domainoid	1	1.000	689	1.000	Domainoid score	I130
eggNOG	1	0.900	-	-		E1_KOG3716
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	802	1.000	Inparanoid score	I475
OMA	1	1.010	-	-		QHG56619
OrthoDB	1	1.010	-	-		D228690at33208
OrthoFinder	1	1.000	-	-		FOG0002000
OrthoInspector	1	1.000	-	-		otm24464
orthoMCL	1	0.900	-	-		OOG6_102071
Panther	1	1.100	-	-	O	PTHR22589
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X480
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.770