DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment whd and Cpt1c

DIOPT Version :9

Sequence 1:	NP_001163111.1	Gene:	whd / 36109	FlyBaseID:	FBgn0261862	Length:	782	Species:	Drosophila melanogaster
Sequence 2:	XP_006229128.1	Gene:	Cpt1c / 308579	RGDID:	1305384	Length:	802	Species:	Rattus norvegicus

Alignment Length:	775	Identity:	327/775 - (42%)
Similarity:	463/775 - (59%)	Gaps:	24/775 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAEAHAAVAFSFAITHEGFDINYDHEVLNLVWNSGVRSWKKRLARARNGVRNGVYPA-HIQSLWL 64
            |||||.|.:...:::.:|.::.....|...::.|.:||||:.|.|..|....||.|| .:..|:|
  Rat     1 MAEAHQASSLLSSLSSDGAEVELSSSVWQEIYLSALRSWKRNLWRVWNDFLAGVVPATPLSWLFL 65

  Fly    65 ISAIALGLHFAGYQAPFNLTNRILVHLPSNTINW-----QVTACFLAAL---VVWLSICFTMRYT 121
            .|.|.|.. .........|..:|...||    :|     |:.....||:   .:|.::.||:...
  Rat    66 FSTIQLAC-LLQLDPSLGLMEKIKELLP----DWGGQHHQLQGLLAAAVFASCLWGTLIFTLHVA 125

  Fly   122 LKLLLMYKGWMYESRAPGSRVSLPTMLWVAVVRVLSSWNKPGLYSFQGSLPRLPLPSVKDTMTRY 186
            |:|||.:.||:.|   |...:|.||..|:|:||:.|. ..|.|:|||.:|||.|:|..::|:.:|
  Rat   126 LRLLLSHHGWLLE---PHGTMSSPTKTWLALVRIFSG-RHPRLFSFQRALPRQPVPGAQETVRKY 186

  Fly   187 LRSVRPLLDDENYTRMERLAKEFEQTIGKKLQWYLILKSWWSTNYVSDWWEEYVYLRGRSPLCVN 251
            |.|:||:|.|:.:..:..||.:|.:....:||.||.||||.::|||||||||:||||.|..| ||
  Rat   187 LESMRPVLRDDAFDSVVALANDFLRLQAPRLQLYLQLKSWCASNYVSDWWEEFVYLRSRGSL-VN 250

  Fly   252 SNFY-GTDAIFMNLTDKQAARAANVISLLLNFRRLIEHQELQPIMVQGMIPLCSWQYERTFNTAR 315
            |.:| ..|.:::..|..|||||.|.:..||.:|.|:..||:.|.::.||.||||.||||.|||.|
  Rat   251 STYYMMQDFLYVTPTPLQAARAGNAVHTLLLYRHLLNRQEIPPTLLMGMRPLCSAQYERMFNTTR 315

  Fly   316 VPGLETDRIIHYRDSNHIVVLHKGCYYKMLIYYKGRILRPCELQVQIEEILKGKATPVEGEEHLA 380
            :||:|.|.:.|.:||.|:.|.|:|.::::..:....:|.|..|:.|.:.||...:.....|||||
  Rat   316 IPGVEKDYLCHLQDSQHVAVFHQGRFFRVGTHSSNGLLSPRALEQQFQYILDDPSPACPLEEHLA 380

  Fly   381 ALTAWNRSKWAEARNTFFSWGVNQTSLRTIESAAFVLSLDDEPFEFDLARPEL-LDNFGKKLLHG 444
            ||||..||.||:.|.:..:...  |:|.|:|.|||.:|||.||.......|.. ||.:...||.|
  Rat   381 ALTAAPRSMWAQVRESVKTHAA--TALETVEGAAFFVSLDSEPAGLTRENPAASLDTYAHTLLTG 443

  Fly   445 NGYNRWFDKCFTVCVGTNGRVGFNAEHTWSDAAIASHMWENLIVDDLVSDGYDETGNTKGTPAFQ 509
            .|::|||||.||:.|.:||::|.:.||:|:|..:|.|:||..:..:....||...|:.||.|...
  Rat   444 QGHDRWFDKSFTLIVFSNGKLGLSVEHSWADCPVAGHLWEFTLATECFQLGYATDGHCKGHPDPA 508

  Fly   510 PPTPTRLTWDL-KPCLAQIEEATIDVTKLINEVNLRILVHQDYGKGFMKKCRISPDAYIQMALQL 573
            .|.|.||.||| |.....|..|......|...::..:.....:||.|:|.|.:|.|::||:.|||
  Rat   509 LPKPQRLQWDLPKQIQPSISLALRGAKTLSGNIDCHVFPFFHFGKSFIKGCHVSSDSFIQLVLQL 573

  Fly   574 AYYRDAGRFSLTYEASMTRLFREGRTETVRPCTIESSAWVKAMQNPNTTNDERVKMMQAACDRHQ 638
            |::||.|:|.||||::|||||.||||||||.||.|:..:|:||:|...|:.:.:.:.:.|.|:||
  Rat   574 AHFRDRGQFCLTYESAMTRLFLEGRTETVRSCTREACQFVRAMENKERTDQQCLALFREAVDKHQ 638

  Fly   639 LGYQDAMCGRGIDRHLFCLYVVSKYLEVDSPFLNEVLSEPWRLSTSQTPHGQTPKMDLKKHPNCI 703
            ...:.||.|:|||||||.||::|:.|.:.||||.:|.|:.|.|||||.|..||...|:..:|:.:
  Rat   639 ALLKAAMSGQGIDRHLFALYIMSRLLHMQSPFLTQVQSQQWLLSTSQIPVQQTHLFDVHNYPDYV 703

  Fly   704 SAGGGFGPVADDGYGVSYIIAGENLIFFHISAKTTCQQTDVHRFAQNISQALSDIRSMFE 763
            |:||||||..|.|||||||..|||.|.||||:|.:..:||.||..|:|..||.|:.|:|:
  Rat   704 SSGGGFGPAHDHGYGVSYIFMGENAISFHISSKQSSTETDSHRLGQHIEDALLDVASLFQ 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
whd	NP_001163111.1	CPT_N	1..45	CDD:293093	14/43 (33%)
whd	NP_001163111.1	Carn_acyltransf	171..759	CDD:279140	268/590 (45%)
Cpt1c	XP_006229128.1	CPT_N	1..46	CDD:293093	14/44 (32%)
Cpt1c	XP_006229128.1	Carn_acyltransf	171..758	CDD:279140	267/589 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341469
Domainoid	1	1.000	673	1.000	Domainoid score	I134
eggNOG	1	0.900	-	-		E1_KOG3716
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	787	1.000	Inparanoid score	I492
OMA	1	1.010	-	-		QHG56619
OrthoDB	1	1.010	-	-		D228690at33208
OrthoFinder	1	1.000	-	-		FOG0002000
OrthoInspector	1	1.000	-	-		otm45966
orthoMCL	1	0.900	-	-		OOG6_102071
Panther	1	1.100	-	-	O	PTHR22589
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X480
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.770