DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment whd and Cpt1b

DIOPT Version :9

Sequence 1:	NP_001163111.1	Gene:	whd / 36109	FlyBaseID:	FBgn0261862	Length:	782	Species:	Drosophila melanogaster
Sequence 2:	XP_006242242.1	Gene:	Cpt1b / 25756	RGDID:	2397	Length:	775	Species:	Rattus norvegicus

Alignment Length:	774	Identity:	388/774 - (50%)
Similarity:	511/774 - (66%)	Gaps:	16/774 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAEAHAAVAFSFAITHEGFDINYDHEVLNLVWNSGVRSWKKRLARARNGVRNGVYPAHIQSLWLI 65
            |||||.||||.|.:|.:|.|.....|.|..::.||:.||||||.|.:||:..||||....| ||:
  Rat     1 MAEAHQAVAFQFTVTPDGVDFRLSREALRHIYLSGINSWKKRLIRIKNGILRGVYPGSPTS-WLV 64

  Fly    66 SAIA-LGLHFAGYQAPFNLTNRILVHLPS--NTINWQVTACFLAALV----VWLSICFTMRYTLK 123
            ..:| :|.::........|.:.|...||:  .:.....|...|:.::    ||.:..|..|.|||
  Rat    65 VVMATVGSNYCKVDISMGLVHCIQRCLPTRYGSYGTPQTETLLSMVIFSTGVWATGIFLFRQTLK 129

  Fly   124 LLLMYKGWMYESRAPGSRVSLPTMLWVAVVRVLSSWNKPGLYSFQGSLPRLPLPSVKDTMTRYLR 188
            |||.|.|||:|..   |:.|..|.:|...||:||| .:|.|||||.|||:||:|||..|:.|||.
  Rat   130 LLLSYHGWMFEMH---SKTSHATKIWAICVRLLSS-RRPMLYSFQTSLPKLPVPSVPATIHRYLD 190

  Fly   189 SVRPLLDDENYTRMERLAKEFEQTIGKKLQWYLILKSWWSTNYVSDWWEEYVYLRGRSPLCVNSN 253
            |||||||||.|.|||.|||||:..|..:||.||:|||||:|||||||||||||||||||:.||||
  Rat   191 SVRPLLDDEAYFRMESLAKEFQDKIAPRLQKYLVLKSWWATNYVSDWWEEYVYLRGRSPIMVNSN 255

  Fly   254 FYGTDAIFMNLTDKQAARAANVISLLLNFRRLIEHQELQPIMVQGMIPLCSWQYERTFNTARVPG 318
            :|..|.:.:..|.:||||..|.:..::.:||.::.:|::|:|..||:|:||:|.||.|||.|:||
  Rat   256 YYAMDFVLIKNTSQQAARLGNTVHAMIMYRRKLDREEIKPVMALGMVPMCSYQMERMFNTTRIPG 320

  Fly   319 LETDRIIHYRDSNHIVVLHKGCYYKMLIYYKGRILRPCELQVQIEEILKGKATPVEGEEHLAALT 383
            .|||.:.|..:|.|:.|.|||.::|:.:|....:|:|.:|::|.:.||...:.|..|||.|||||
  Rat   321 KETDLLQHLSESRHVAVYHKGRFFKVWLYEGSCLLKPRDLEMQFQRILDDTSPPQPGEEKLAALT 385

  Fly   384 AWNRSKWAEARNTFFSWGVNQTSLRTIESAAFVLSLDDEPFEFDLARPELLDNFGKKLLHGNGYN 448
            |..|.:|||||..|||.|.|:.||.|||.|||.::||::...::......|..:||.|||||.||
  Rat   386 AGGRVEWAEARQKFFSSGKNKMSLDTIERAAFFVALDEDSHCYNPDDEASLSLYGKSLLHGNCYN 450

  Fly   449 RWFDKCFTVCVGTNGRVGFNAEHTWSDAAIASHMWENLIVDDLVSDGYDETGNTKGTPAFQPPTP 513
            |||||.||:....||::|.|.||:|:||.|..|:||.::..|....||.|||:..|.|..:.|.|
  Rat   451 RWFDKSFTLISCKNGQLGLNTEHSWADAPIIGHLWEFVLATDTFHLGYTETGHCVGEPNTKLPPP 515

  Fly   514 TRLTWDL-KPCLAQIEEATIDVTKLINEVNLRILVHQDYGKGFMKKCRISPDAYIQMALQLAYYR 577
            .|:.||: :.|...||.:......|.::|.|.......:|||.:||||.||||::|:|||||::|
  Rat   516 QRMQWDIPEQCQTAIENSYQVAKALADDVELYCFQFLPFGKGLIKKCRTSPDAFVQIALQLAHFR 580

  Fly   578 DAGRFSLTYEASMTRLFREGRTETVRPCTIESSAWVKAMQNPNTTNDERVKMMQAACDRHQLGYQ 642
            |.|:|.|||||||||:||||||||||.||.||:|:|:||...:....:...:.:.|.::||..|:
  Rat   581 DKGKFCLTYEASMTRMFREGRTETVRSCTSESTAFVRAMMTGSHKKQDLQDLFRKASEKHQNMYR 645

  Fly   643 DAMCGRGIDRHLFCLYVVSKYLEVDSPFLNEVLSEPWRLSTSQTPHGQTPKMDLKKHPNCISAGG 707
            .||.|.||||||||||:|||||.|.||||:|||||||.|||||.|..|....|.|::||.:.|||
  Rat   646 LAMTGAGIDRHLFCLYIVSKYLGVRSPFLDEVLSEPWSLSTSQIPQFQICMFDPKQYPNHLGAGG 710

  Fly   708 GFGPVADDGYGVSYIIAGENLIFFHISAKTTCQQT---DVHRFAQNISQALSDIRSMFE 763
            |||||||.||||||:|||||.:|||:|:|.:..:|   :..||..:|.|||.||..:|:
  Rat   711 GFGPVADHGYGVSYMIAGENTMFFHVSSKLSSSETFPQNALRFGNHIRQALLDIADLFK 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
whd	NP_001163111.1	CPT_N	1..45	CDD:293093	23/43 (53%)
whd	NP_001163111.1	Carn_acyltransf	171..759	CDD:279140	314/591 (53%)
Cpt1b	XP_006242242.1	CPT_N	1..47	CDD:406797	24/45 (53%)
Cpt1b	XP_006242242.1	Carn_acyltransf	173..764	CDD:395612	313/590 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341470
Domainoid	1	1.000	673	1.000	Domainoid score	I134
eggNOG	1	0.900	-	-		E1_KOG3716
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	787	1.000	Inparanoid score	I492
OMA	1	1.010	-	-		QHG56619
OrthoDB	1	1.010	-	-		D228690at33208
OrthoFinder	1	1.000	-	-		FOG0002000
OrthoInspector	1	1.000	-	-		otm45966
orthoMCL	1	0.900	-	-		OOG6_102071
Panther	1	1.100	-	-	O	PTHR22589
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X480
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770