DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment whd and cpt-1

DIOPT Version :9

Sequence 1:	NP_001163111.1	Gene:	whd / 36109	FlyBaseID:	FBgn0261862	Length:	782	Species:	Drosophila melanogaster
Sequence 2:	NP_496721.2	Gene:	cpt-1 / 174912	WormBaseID:	WBGene00012907	Length:	779	Species:	Caenorhabditis elegans

Alignment Length:	778	Identity:	361/778 - (46%)
Similarity:	516/778 - (66%)	Gaps:	23/778 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAEAHAAVAFSFAITHEGFDINYDHEVLNLVWNSGVRSWKKRLARARNGVRNGVYPAHIQSLWLI 65
            ||||.:|.|.|||:||:|..::||.|:|..:|:...||:|:|..|.||...||::||:..:|.|:
Worm     1 MAEARSAAALSFAVTHDGVSVSYDQELLRDIWHGISRSYKRRTGRFRNDFMNGMFPANSWTLGLV 65

  Fly    66 -------SAIALGLHFAGYQAPFNLTNRILVHLPSNTINWQVTACFLAALVVWLSICFTMRYTLK 123
                   |.|...|.|..:  || :.|.|:.::..:....|..:..:|..::||.....:|.::|
Worm    66 VGAVAVFSVIKHDLSFGIF--PF-IQNYIVHYIFGDGYLGQSISIAVAGALLWLIFVQLLRLSIK 127

  Fly   124 LLLMYKGWMYESRAPGSRVSLPTMLWVAVVRVLSSWNKPGLYSFQGSLPRLPLPSVKDTMTRYLR 188
            .||.||||||||  ||..||..|.||:.|:.::|... |.|:||||:|||||||::.||:.::|.
Worm   128 TLLEYKGWMYES--PGKPVSKATKLWLGVLHIISKAG-PMLHSFQGALPRLPLPNLDDTVRKHLL 189

  Fly   189 SVRPLLDDENYTRMERLAKEFEQTIGKKLQWYLILKSWWSTNYVSDWWEEYVYLRGRSPLCVNSN 253
            |::|:|.||.:..:|.|::.|.:.:|::||.||.||||:|:|||:|||||:||:|.|||:.:|||
Worm   190 SMKPILSDEEFQELEFLSERFRKGVGRRLQRYLTLKSWFSSNYVTDWWEEFVYMRQRSPIMINSN 254

  Fly   254 FYGTDAIFMNLTDKQAARAANVISLLLNFRRLIEHQELQPIMV--QGMIPLCSWQYERTFNTARV 316
            :||.|.:..:.|..||:||||:....|.|||:::.||:.|..:  :..:|.|:.||||.|||.||
Worm   255 YYGFDTLNEHPTQNQASRAANLTYTSLQFRRMVDRQEVSPFSISPRTKVPFCTMQYERLFNTCRV 319

  Fly   317 PGLETDRIIHYRDSNHIVVLHKGCYYKMLIYYKGRILRPCELQVQIEEILKGKATPVEGEEHLAA 381
            ||.|.||::|:.|:.||.|..:|.::|::::...|:|..||||||.:.||.....|.|||.|||:
Worm   320 PGEEVDRLLHWDDAKHIAVYCRGVWFKLIVHNGKRLLEACELQVQYDAILAHTHEPSEGEMHLAS 384

  Fly   382 LTAWNRSKWAEARNTFFSWGVNQTSLRTIESAAFVLSLDDEPFEFDLARPELLDNFGKKLLHGNG 446
            |||..|:.||:.|...|..|||:|||..||.||||:.||||...:|...|..||::...||||..
Worm   385 LTAGERADWAKTRRAHFRSGVNKTSLNDIERAAFVVILDDEETHYDPQDPSKLDHWAHNLLHGKA 449

  Fly   447 YNRWFDKCFTVCVGTNGRVGFNAEHTWSDAAIASHMWENLIVDDLVSDGYDETGNTKGTPAFQPP 511
            ::|||||.|.:.:..||.||.|.||:|.|||:.:|..|..::.|:|..||||.|..||.|. :..
Worm   450 HDRWFDKSFNLIISKNGHVGINTEHSWGDAAVMAHFTEWSLLQDIVFIGYDENGRCKGEPK-EKL 513

  Fly   512 TPTRLTWDL-KPCLAQIEEATIDVTKLINEVNLRILVHQDYGKGFMKKCRISPDAYIQMALQLAY 575
            ||.||.|:: .|.|.||.::......||.:|.:.:||..||||||.||.::||||::||.||..|
Worm   514 TPERLKWEIPAPALDQIRKSMEVANALIADVEMSLLVWTDYGKGFAKKLKVSPDAFLQMTLQYTY 578

  Fly   576 YRDAGRFSLTYEASMTRLFREGRTETVRPCTIESSAWVKAMQNPNTTNDERVKMMQAACDRHQLG 640
            :::..:||||||||||||||||||||||.||::||.:|::|.:.:.|..:|:::::.|||:||..
Worm   579 FKNQNKFSLTYEASMTRLFREGRTETVRSCTVQSSDFVRSMLDASKTPQDRLQLLRKACDKHQEL 643

  Fly   641 YQDAMCGRGIDRHLFCLYVVSKYLEVDSPFLNEVLSEPWRLSTSQTPHGQTPKMDLKKHPN---- 701
            |:|||||:|:|||||.|||:.:|||.:|||.:.:....:.|||||||..|. :.|.|...|
Worm   644 YRDAMCGQGVDRHLFALYVIKRYLEEESPFFDNIFPPTYLLSTSQTPMNQC-EADAKGLSNEVRL 707

  Fly   702 -CISAGGGFGPVADDGYGVSYIIAGENLIFFHISAKTTCQQTDVHRFAQNISQALSDIRSMFE 763
             .|:||||||||||.|||||||:|||:.:.||||:|.:...|....|.:.:.::|:|::.:.|
Worm   708 RLITAGGGFGPVADRGYGVSYIVAGEDTLSFHISSKRSADNTSSREFREELKRSLNDMKKLAE 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
whd	NP_001163111.1	CPT_N	1..45	CDD:293093	21/43 (49%)
whd	NP_001163111.1	Carn_acyltransf	171..759	CDD:279140	291/595 (49%)
cpt-1	NP_496721.2	CPT_N	1..46	CDD:293093	21/44 (48%)
cpt-1	NP_496721.2	Carn_acyltransf	172..766	CDD:279140	291/595 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159644
Domainoid	1	1.000	598	1.000	Domainoid score	I96
eggNOG	1	0.900	-	-		E1_KOG3716
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H136039
Inparanoid	1	1.050	706	1.000	Inparanoid score	I338
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56619
OrthoDB	1	1.010	-	-		D228690at33208
OrthoFinder	1	1.000	-	-		FOG0002000
OrthoInspector	1	1.000	-	-		oto19017
orthoMCL	1	0.900	-	-		OOG6_102071
Panther	1	1.100	-	-	LDO	PTHR22589
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4374
SonicParanoid	1	1.000	-	-		X480
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.840