DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment whd and CPT2

DIOPT Version :9

Sequence 1:	NP_001163111.1	Gene:	whd / 36109	FlyBaseID:	FBgn0261862	Length:	782	Species:	Drosophila melanogaster
Sequence 2:	NP_000089.1	Gene:	CPT2 / 1376	HGNCID:	2330	Length:	658	Species:	Homo sapiens

Alignment Length:	711	Identity:	211/711 - (29%)
Similarity:	324/711 - (45%)	Gaps:	139/711 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 LMYKGWMYESRAPGSRVSLPTMLWVAVVRVLSSWNKPGLY---------SFQGSLPRLPLPSVKD 181
            |:.:.|   .|.|......|:       |.||:.:.||.|         .:|.||||||:|.::|
Human     5 LLLRAW---PRGPAVGPGAPS-------RPLSAGSGPGQYLQRSIVPTMHYQDSLPRLPIPKLED 59

  Fly   182 TMTRYLRSVRPLLDDENYTRMERLAKEFEQTIGKKLQWYLIL--KSWWSTNYVSDWWEEYVYLRG 244
            |:.|||.:.:|||:|..:.:.|:..|.||..|||:|...|:.  |....|:|:|..|.: :||..
Human    60 TIRRYLSAQKPLLNDGQFRKTEQFCKSFENGIGKELHEQLVALDKQNKHTSYISGPWFD-MYLSA 123

  Fly   245 RSPLCVNSN-FYGTDAIFMNLTDKQAARAANVISLLLNFRRLIEHQELQP------------IMV 296
            |..:.:|.| |...:....:..:.|..||.|:....:.|.:.:....|:|            |..
Human   124 RDSVVLNFNPFMAFNPDPKSEYNDQLTRATNMTVSAIRFLKTLRAGLLEPEVFHLNPAKSDTITF 188

  Fly   297 QGMI------------------PLCSWQYERTFNTARVPGLETDRIIHYRDSNHIVVLHKGCYYK 343
            :.:|                  ||...||.|.||:.|:|....|.:.....:.|::||.||.:|.
Human   189 KRLIRFVPSSLSWYGAYLVNAYPLDMSQYFRLFNSTRLPKPSRDELFTDDKARHLLVLRKGNFYI 253

  Fly   344 M-LIYYKGRILRPCELQVQIEEILKGKATPVEGEEHLAALTAWNRSKWAEARNTFFSWGVNQTSL 407
            . ::...|.|:.|.|:|..::.|| ..::|.. |..||.||:.||..|||.|....|.| |:.||
Human   254 FDVLDQDGNIVSPSEIQAHLKYIL-SDSSPAP-EFPLAYLTSENRDIWAELRQKLMSSG-NEESL 315

  Fly   408 RTIESAAFVLSLDDEPFEFDLARPELLDNFGKKLLHGNGYNRWFDKCFTVCVGTNGRVGFNAEHT 472
            |.::||.|.|.|||.|.: ||.      :....:|||:|.||||||.|.:.:..:|....:.||:
Human   316 RKVDSAVFCLCLDDFPIK-DLV------HLSHNMLHGDGTNRWFDKSFNLIIAKDGSTAVHFEHS 373

  Fly   473 WSDAAIASHMWENLIVDDLVSDGYDETGNTKGTPAFQPPTP------TRLTWDLKPCL------- 524
            |.|.......:..:.        .|.|.....||..||.|.      .:|.::|...|
Human   374 WGDGVAVLRFFNEVF--------KDSTQTPAVTPQSQPATTDSTVTVQKLNFELTDALKTGITAA 430

  Fly   525 -----AQIEEATIDVTKLINEVNLRILVHQDYGKGFMKKCRISPDAYIQMALQLAYYRDAGRFSL 584
                 |.::..|||..:.           |..||.|:||.::||||..|:|.|:|:.|..|:...
Human   431 KEKFDATMKTLTIDCVQF-----------QRGGKEFLKKQKLSPDAVAQLAFQMAFLRQYGQTVA 484

  Fly   585 TYEASMTRLFREGRTETVRPCTIESSAWVKA-MQNPNTTNDERVKMMQAACDRH--QLGYQDAMC 646
            |||:..|..|:.|||||:||.::.:....:| ::.|:..:...::.|...|.::  ||..:.||
Human   485 TYESCSTAAFKHGRTETIRPASVYTKRCSEAFVREPSRHSAGELQQMMVECSKYHGQLTKEAAM- 548

  Fly   647 GRGIDRHLFCLY-------VVSKYLEVDSPF--LNEVLSEPWRLSTSQTPHGQTPKMDLKKHPNC 702
            |:|.|||||.|.       ::...|.:|..:  :|..:     ||||..   .:|.::|
Human   549 GQGFDRHLFALRHLAAAKGIILPELYLDPAYGQINHNV-----LSTSTL---SSPAVNL------ 599

  Fly   703 ISAGGGFGPVADDGYGVSYIIAGENLIFFHISAKTTCQQTDVHRFAQNISQALSDIRSMFE 763
                |||.||..||:||.|.: .:|.|..::|   :....:...|.|.:.:||.|   ||:
Human   600 ----GGFAPVVSDGFGVGYAV-HDNWIGCNVS---SYPGRNAREFLQCVEKALED---MFD 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
whd	NP_001163111.1	CPT_N	1..45	CDD:293093
whd	NP_001163111.1	Carn_acyltransf	171..759	CDD:279140	196/651 (30%)
CPT2	NP_000089.1	Carn_acyltransf	49..648	CDD:279140	196/654 (30%)
CPT2	NP_000089.1	Coenzyme A binding. /evidence=ECO:0000250	452..464		6/11 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D559299at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920