DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment whd and CPT1B

DIOPT Version :9

Sequence 1:	NP_001163111.1	Gene:	whd / 36109	FlyBaseID:	FBgn0261862	Length:	782	Species:	Drosophila melanogaster
Sequence 2:	NP_001138607.1	Gene:	CPT1B / 1375	HGNCID:	2329	Length:	772	Species:	Homo sapiens

Alignment Length:	773	Identity:	398/773 - (51%)
Similarity:	511/773 - (66%)	Gaps:	17/773 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAEAHAAVAFSFAITHEGFDINYDHEVLNLVWNSGVRSWKKRLARARNGVRNGVYPAHIQSLWLI 65
            |||||.||||.|.:|.:|.|.....|.|..|:.||:.||||||.|.:||:..||||....| ||:
Human     1 MAEAHQAVAFQFTVTPDGVDFRLSREALKHVYLSGINSWKKRLIRIKNGILRGVYPGSPTS-WLV 64

  Fly    66 SAIA-LGLHFAGYQAPFNLTNRILVHLPSNTINWQV--TACFLAALV----VWLSICFTMRYTLK 123
            ..:| :|..|........|.:.|...||.....:|.  |...|:..:    ||::..|..|.|||
Human    65 VIMATVGSSFCNVDISLGLVSCIQRCLPQGCGPYQTPQTRALLSMAIFSTGVWVTGIFFFRQTLK 129

  Fly   124 LLLMYKGWMYESRAPGSRVSLPTMLWVAVVRVLSSWNKPGLYSFQGSLPRLPLPSVKDTMTRYLR 188
            |||.|.|||:|.....|.:   |.:|...:|:||| ..|.|||||.|||:||:|.|..|:.|||.
Human   130 LLLCYHGWMFEMHGKTSNL---TRIWAMCIRLLSS-RHPMLYSFQTSLPKLPVPRVSATIQRYLE 190

  Fly   189 SVRPLLDDENYTRMERLAKEFEQTIGKKLQWYLILKSWWSTNYVSDWWEEYVYLRGRSPLCVNSN 253
            |||||||||.|.|||.|||||:.....:||.||:|||||::||||||||||:||||||||.||||
Human   191 SVRPLLDDEEYYRMELLAKEFQDKTAPRLQKYLVLKSWWASNYVSDWWEEYIYLRGRSPLMVNSN 255

  Fly   254 FYGTDAIFMNLTDKQAARAANVISLLLNFRRLIEHQELQPIMVQGMIPLCSWQYERTFNTARVPG 318
            :|..|.:.:..||.||||..|:|..::.:||.::.:|::|:|..|::|:||:|.||.|||.|:||
Human   256 YYVMDLVLIKNTDVQAARLGNIIHAMIMYRRKLDREEIKPVMALGIVPMCSYQMERMFNTTRIPG 320

  Fly   319 LETDRIIHYRDSNHIVVLHKGCYYKMLIYYKGRILRPCELQVQIEEILKGKATPVEGEEHLAALT 383
            .:||.:.|..||.|:.|.|||.::|:.:|...|:|:|.:|::|.:.||...:.|..|||.|||||
Human   321 KDTDVLQHLSDSRHVAVYHKGRFFKLWLYEGARLLKPQDLEMQFQRILDDPSPPQPGEEKLAALT 385

  Fly   384 AWNRSKWAEARNTFFSWGVNQTSLRTIESAAFVLSLDDEPFEFDLARPELLDNFGKKLLHGNGYN 448
            |..|.:||:||..|||.|.|:.:|..||.|||.::||:|.:.:|......|..:||.|||||.||
Human   386 AGGRVEWAQARQAFFSSGKNKAALEAIERAAFFVALDEESYSYDPEDEASLSLYGKALLHGNCYN 450

  Fly   449 RWFDKCFTVCVGTNGRVGFNAEHTWSDAAIASHMWENLIVDDLVSDGYDETGNTKG--TPAFQPP 511
            |||||.||:....||::|.||||.|:||.|..|:||.::..|....||.|||:..|  .||..|
Human   451 RWFDKSFTLISFKNGQLGLNAEHAWADAPIIGHLWEFVLGTDSFHLGYTETGHCLGKPNPALAP- 514

  Fly   512 TPTRLTWDL-KPCLAQIEEATIDVTKLINEVNLRILVHQDYGKGFMKKCRISPDAYIQMALQLAY 575
             ||||.||: |.|.|.||.:......|.::|.|.......:|||.:||||.||||::|:|||||:
Human   515 -PTRLQWDIPKQCQAVIESSYQVAKALADDVELYCFQFLPFGKGLIKKCRTSPDAFVQIALQLAH 578

  Fly   576 YRDAGRFSLTYEASMTRLFREGRTETVRPCTIESSAWVKAMQNPNTTNDERVKMMQAACDRHQLG 640
            :||.|:|.|||||||||:||||||||||.||.||:|:|:||...:.|..:...:.|.|..:||..
Human   579 FRDRGKFCLTYEASMTRMFREGRTETVRSCTSESTAFVQAMMEGSHTKADLRDLFQKAAKKHQNM 643

  Fly   641 YQDAMCGRGIDRHLFCLYVVSKYLEVDSPFLNEVLSEPWRLSTSQTPHGQTPKMDLKKHPNCISA 705
            |:.||.|.||||||||||:|||||.|.||||.|||||||||||||.|..|....|.::|||.:.|
Human   644 YRLAMTGAGIDRHLFCLYLVSKYLGVSSPFLAEVLSEPWRLSTSQIPQSQIRMFDPEQHPNHLGA 708

  Fly   706 GGGFGPVADDGYGVSYIIAGENLIFFHISAKTTCQQTDVHRFAQNISQALSDIRSMFE 763
            ||||||||||||||||:|||||.||||||:|.:..:|:..||..:|.:||.||..:|:
Human   709 GGGFGPVADDGYGVSYMIAGENTIFFHISSKFSSSETNAQRFGNHIRKALLDIADLFQ 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
whd	NP_001163111.1	CPT_N	1..45	CDD:293093	24/43 (56%)
whd	NP_001163111.1	Carn_acyltransf	171..759	CDD:279140	323/590 (55%)
CPT1B	NP_001138607.1	CPT_N	1..46	CDD:293093	24/44 (55%)
		Carn_acyltransf	173..761	CDD:279140	322/589 (55%)
		Coenzyme A binding. /evidence=ECO:0000250	555..567		8/11 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147646
Domainoid	1	1.000	661	1.000	Domainoid score	I153
eggNOG	1	0.900	-	-		E1_KOG3716
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	774	1.000	Inparanoid score	I532
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56619
OrthoDB	1	1.010	-	-		D228690at33208
OrthoFinder	1	1.000	-	-		FOG0002000
OrthoInspector	1	1.000	-	-		otm41826
orthoMCL	1	0.900	-	-		OOG6_102071
Panther	1	1.100	-	-	O	PTHR22589
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4374
SonicParanoid	1	1.000	-	-		X480
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800