DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment whd and Cpt2

DIOPT Version :9

Sequence 1:	NP_001163111.1	Gene:	whd / 36109	FlyBaseID:	FBgn0261862	Length:	782	Species:	Drosophila melanogaster
Sequence 2:	NP_034079.2	Gene:	Cpt2 / 12896	MGIID:	109176	Length:	658	Species:	Mus musculus

Alignment Length:	713	Identity:	209/713 - (29%)
Similarity:	325/713 - (45%)	Gaps:	143/713 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 LMYKGWMYESRAPGSRVSLPTMLWVAVVRVLSSWNKPGLY---------SFQGSLPRLPLPSVKD 181
            |:.:.|   .|.|...:..|:       |.||:.:.|..|         .:|.||||||:|.::|
Mouse     5 LLLRDW---PRCPSLVLGAPS-------RPLSAVSGPAEYLQHSIVPTMHYQDSLPRLPIPKLED 59

  Fly   182 TMTRYLRSVRPLLDDENYTRMERLAKEFEQTIGKKLQWYLIL--KSWWSTNYVSDWWEEYVYLRG 244
            ||.|||.:.:|||:|..:.:.|.|.|:||..|||:|..:|:.  |....|:|:|..|.: :||..
Mouse    60 TMKRYLSAQKPLLNDSQFRKTEVLCKDFENGIGKELHAHLLAQDKQNKHTSYISGPWFD-MYLTA 123

  Fly   245 RSPLCVNSN-FYGTDAIFMNLTDKQAARAANVISLLLNFRRLIEHQELQP--------------- 293
            |..:.:|.| |...:....:..:.|..||.|:....:.|.:.:....|:|
Mouse   124 RDSVVLNFNPFMAFNPDPKSEYNDQLTRATNLTVSAVRFLKTLRAGLLEPEVFHLNPARSDTDAF 188

  Fly   294 -IMVQGMIPLCSW--------------QYERTFNTARVPGLETDRIIHYRDSNHIVVLHKGCYYK 343
             .:::.:....||              ||.|.||:.|:|....|.:.....:.|::||.||.:|.
Mouse   189 KRLIRFVPSSLSWYGAYLVNAYPLDMSQYFRLFNSTRIPKPSRDELFTDTKARHLLVLRKGHFYV 253

  Fly   344 M-LIYYKGRILRPCELQVQIEEILKGKATPVEGEEHLAALTAWNRSKWAEARNTFFSWGVNQTSL 407
            . ::...|.|:.|.|:|..::.|| ..::||. |..||.||:.||..|||.|......| |:.:|
Mouse   254 FDVLDQDGNIVNPSEIQAHLKYIL-SDSSPVP-EFPLAYLTSENRDVWAELRQKLIHGG-NEETL 315

  Fly   408 RTIESAAFVLSLDDEPFEFDLARPELLDNFGKKLLHGNGYNRWFDKCFTVCVGTNGRVGFNAEHT 472
            |.::||.|.|.|||.|.: ||.      :....:|||:|.||||||.|.:.|..:|....:.||.
Mouse   316 RKVDSAVFCLCLDDFPMK-DLV------HLSHTMLHGDGTNRWFDKSFNLIVAKDGTAAVHFEHA 373

  Fly   473 WSDAAIASHMWENLIVDDLVSDGYDETGNTKGTPAFQP---PTPT-------RLTWDLKPCL--- 524
            |.|.......:..:..|            :..|||..|   |..|       :|::.|...|
Mouse   374 WGDGVAVLRFFNEVFRD------------STQTPAIAPQSQPAATDSSVSVQKLSFKLSSALKAG 426

  Fly   525 ---------AQIEEATIDVTKLINEVNLRILVHQDYGKGFMKKCRISPDAYIQMALQLAYYRDAG 580
                     |.::..|||..:.           |..||.|:||.::||||..|:|.|:|:.|..|
Mouse   427 VTAAKEKFDATMKTLTIDAIQF-----------QRGGKEFLKKKKLSPDAVAQLAFQMAFLRQYG 480

  Fly   581 RFSLTYEASMTRLFREGRTETVRPCTIESSAWVKA-MQNPNTTNDERVKMMQAACDRH--QLGYQ 642
            :...|||:..|..|:.|||||:||.:|.:....:| ::.|:..:...::.|.|.|.::  ||..:
Mouse   481 QTVATYESCSTAAFKHGRTETIRPASIFTKRCSEAFVREPSKHSVGELQHMMAECSKYHGQLTKE 545

  Fly   643 DAMCGRGIDRHLFCLYVVSKYLEVDSPFLNEVLSEPWR-------LSTSQTPHGQTPKMDLKKHP 700
            .|| |:|.|||||.|..::....|..|   |:..:|..       ||||..   .:|.:.|
Mouse   546 AAM-GQGFDRHLFALRYLAAARGVTLP---ELYQDPAYQRINHNILSTSTL---SSPAVSL---- 599

  Fly   701 NCISAGGGFGPVADDGYGVSYIIAGENLIFFHISAKTTCQQTDVHRFAQNISQALSDIRSMFE 763
                  |||.||..||:|::|.: .::.|..::|:.:   ..:...|...:.:.|.|   ||:
Mouse   600 ------GGFAPVVPDGFGIAYAV-HDDWIGCNVSSYS---GRNAREFLHCVQKCLED---MFD 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
whd	NP_001163111.1	CPT_N	1..45	CDD:293093
whd	NP_001163111.1	Carn_acyltransf	171..759	CDD:279140	195/653 (30%)
Cpt2	NP_034079.2	Carn_acyltransf	49..648	CDD:279140	195/656 (30%)
Cpt2	NP_034079.2	Coenzyme A binding. /evidence=ECO:0000250	452..464		6/11 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D559299at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920