DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment whd and Cpt1b

DIOPT Version :9

Sequence 1:	NP_001163111.1	Gene:	whd / 36109	FlyBaseID:	FBgn0261862	Length:	782	Species:	Drosophila melanogaster
Sequence 2:	NP_034078.2	Gene:	Cpt1b / 12895	MGIID:	1098297	Length:	772	Species:	Mus musculus

Alignment Length:	771	Identity:	391/771 - (50%)
Similarity:	508/771 - (65%)	Gaps:	13/771 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAEAHAAVAFSFAITHEGFDINYDHEVLNLVWNSGVRSWKKRLARARNGVRNGVYPAHIQSLWLI 65
            |||||.||||.|.:|.:|.|.....|.|..::.||:.||||||.|.:||:..||||....| ||:
Mouse     1 MAEAHQAVAFQFTVTPDGVDFRLSREALRHIYLSGINSWKKRLIRIKNGILRGVYPGSPTS-WLV 64

  Fly    66 SAIA-LGLHFAGYQAPFNLTNRILVHLPSNTINWQV--TACFLAALV----VWLSICFTMRYTLK 123
            ..:| :|.::........|.:.|...||....::..  |...|:.::    ||.:..|..|.|||
Mouse    65 VVMATVGSNYCKVDISMGLVDCIQRCLPERYGHFGTPQTEALLSMVIFSTGVWATGIFFFRQTLK 129

  Fly   124 LLLMYKGWMYESRAPGSRVSLPTMLWVAVVRVLSSWNKPGLYSFQGSLPRLPLPSVKDTMTRYLR 188
            |||.|.|||:|..   |:.|..|.:|...||:||| .:|.|||||.|||:||:|||..|:.|||.
Mouse   130 LLLSYHGWMFEMH---SKTSHATKIWAICVRLLSS-RRPMLYSFQTSLPKLPVPSVPATIHRYLD 190

  Fly   189 SVRPLLDDENYTRMERLAKEFEQTIGKKLQWYLILKSWWSTNYVSDWWEEYVYLRGRSPLCVNSN 253
            |||||||||.|.|||.|||||:.....:||.||:|||||:|||||||||||||||.||||.||||
Mouse   191 SVRPLLDDEAYYRMETLAKEFQDKTAPRLQKYLVLKSWWATNYVSDWWEEYVYLRSRSPLMVNSN 255

  Fly   254 FYGTDAIFMNLTDKQAARAANVISLLLNFRRLIEHQELQPIMVQGMIPLCSWQYERTFNTARVPG 318
            :|..|.:.:..|:.||||..|.:..::.:||.::.:|::|:|..||:|:||:|.||.|||.|:||
Mouse   256 YYAMDFVLIKNTNVQAARLGNAVHAMIMYRRKLDREEIKPVMALGMVPMCSYQMERMFNTTRIPG 320

  Fly   319 LETDRIIHYRDSNHIVVLHKGCYYKMLIYYKGRILRPCELQVQIEEILKGKATPVEGEEHLAALT 383
            .|||.:.|..:|.|:.|.|||.::|:.:|...|:|:|.:|::|.:.||...:.|..|||.|||||
Mouse   321 KETDLLQHLSESRHVAVYHKGRFFKVWLYEGSRLLKPRDLEMQFQRILDDPSPPQPGEEKLAALT 385

  Fly   384 AWNRSKWAEARNTFFSWGVNQTSLRTIESAAFVLSLDDEPFEFDLARPELLDNFGKKLLHGNGYN 448
            |..|.:|||||.||||.|.|:.||..||.|||.::||::...::......|..:||.|||||.||
Mouse   386 AGGRVEWAEARQTFFSSGKNKMSLDAIERAAFFVTLDEDSHCYNPDDETSLSLYGKALLHGNCYN 450

  Fly   449 RWFDKCFTVCVGTNGRVGFNAEHTWSDAAIASHMWENLIVDDLVSDGYDETGNTKGTPAFQPPTP 513
            |||||.||:....||.:|.|.||:|:||.|..|:||.::..|....||.|||:..|.|....|.|
Mouse   451 RWFDKSFTLISCKNGLLGLNTEHSWADAPIIGHLWEFVLGTDTFHLGYTETGHCVGEPNTTLPPP 515

  Fly   514 TRLTWDL-KPCLAQIEEATIDVTKLINEVNLRILVHQDYGKGFMKKCRISPDAYIQMALQLAYYR 577
            .||.||: :.|...||.:......|.::|.|.......:|||.:||||.||||::|:|||||::|
Mouse   516 QRLPWDIPEQCREAIENSYQVAKALADDVELYCFQFLPFGKGLIKKCRTSPDAFVQIALQLAHFR 580

  Fly   578 DAGRFSLTYEASMTRLFREGRTETVRPCTIESSAWVKAMQNPNTTNDERVKMMQAACDRHQLGYQ 642
            |.|:|.|||||||||:||||||||||.||.||:|:|:||...:....:...:.:.|.::||..|:
Mouse   581 DKGKFCLTYEASMTRMFREGRTETVRSCTNESAAFVQAMMKGSHKKQDLQDLFRKASEKHQNMYR 645

  Fly   643 DAMCGRGIDRHLFCLYVVSKYLEVDSPFLNEVLSEPWRLSTSQTPHGQTPKMDLKKHPNCISAGG 707
            .||.|.||||||||||:|||||.|.||||.|||||||.|||||.|..|....|.|::||.:.|||
Mouse   646 LAMTGAGIDRHLFCLYIVSKYLGVSSPFLAEVLSEPWSLSTSQIPQFQICMFDPKQYPNHLGAGG 710

  Fly   708 GFGPVADDGYGVSYIIAGENLIFFHISAKTTCQQTDVHRFAQNISQALSDIRSMFE 763
            ||||||||||||||:|||||.:|||||:|.:..:|:..||..:|.|||.||..:|:
Mouse   711 GFGPVADDGYGVSYMIAGENTMFFHISSKYSSSETNAQRFGNHIRQALLDIAELFK 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
whd	NP_001163111.1	CPT_N	1..45	CDD:293093	23/43 (53%)
whd	NP_001163111.1	Carn_acyltransf	171..759	CDD:279140	317/588 (54%)
Cpt1b	NP_034078.2	CPT_N	1..46	CDD:293093	23/44 (52%)
		Carn_acyltransf	173..761	CDD:279140	316/587 (54%)
		Coenzyme A binding. /evidence=ECO:0000250	555..567		8/11 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837727
Domainoid	1	1.000	668	1.000	Domainoid score	I151
eggNOG	1	0.900	-	-		E1_KOG3716
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	785	1.000	Inparanoid score	I520
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56619
OrthoDB	1	1.010	-	-		D228690at33208
OrthoFinder	1	1.000	-	-		FOG0002000
OrthoInspector	1	1.000	-	-		otm43877
orthoMCL	1	0.900	-	-		OOG6_102071
Panther	1	1.100	-	-	O	PTHR22589
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4374
SonicParanoid	1	1.000	-	-		X480
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.800