Protein Alignment whd and CPT1C

DIOPT Version :10

• Sequence 1: NP_001163111.1
• Gene: whd / 36109
• FlyBaseID: FBgn0261862
• Length: 782
• Species: Drosophila melanogaster
• Sequence 2: NP_001365411.1
• Gene: CPT1C / 126129
• HGNCID: 18540
• Length: 825
• Species: Homo sapiens
• Alignment Length: 821
• Identity: 342/821 - (41%)
• Similarity: 478/821 - (58%)
• Gaps: 84/821 - (10%)

  Fly     1 MAEAHAAVAFSFAITHEGFDINYDHEVLNLVWNSGVRSWKKRLARARNGVRNGVYPAH-IQSLWL 64
            |||||.||.|..::|.:|.::.....||..::.||:||||:.|:|..|....||:||. :..|:|
Human     1 MAEAHQAVGFRPSLTSDGAEVELSAPVLQEIYLSGLRSWKRHLSRFWNDFLTGVFPASPLSWLFL 65

  Fly    65 ISAIALGLHFAGYQAPFNLTNRILVHLPSNTINW--------QVTACFLAALVVWLSICFTMRYT 121
            .|||.|. .|........|..:|...||    :|        .|.|..|.|..:|.::.||:...
Human    66 FSAIQLA-WFLQLDPSLGLMEKIKELLP----DWGGQHHGLRGVLAAALFASCLWGALIFTLHVA 125

  Fly   122 LKLLLMYKGWMYESRAPGSRVSLPTMLWVAVVRVLSSWNKPGLYSFQGSLPRLPLPSVKDTMTRY 186
            |:|||.|.||:.|   |...:|.||..|:|:||:.|. ..|.|:|:|.||||.|:|||:||:.:|
Human   126 LRLLLSYHGWLLE---PHGAMSSPTKTWLALVRIFSG-RHPMLFSYQRSLPRQPVPSVQDTVRKY 186

  Fly   187 LRSVRPLLDDENYTRMERLAKEFEQTIGKKLQWYLILKSWWSTNYVSDWWEEYVYLRGRSPLCVN 251
            |.||||:|.||::.....||:||.:.....|||||.|||||::|||||||||:||||.|:||.||
Human   187 LESVRPILSDEDFDWTAVLAQEFLRLQASLLQWYLRLKSWWASNYVSDWWEEFVYLRSRNPLMVN 251

  Fly   252 SNFYGTDAIFMNLTDKQAARAANVISLLLNFRRLIEHQELQPI---------------------- 294
            ||:|           ..||||.|.:..||.:|..:..||:.|:
Human   252 SNYY-----------MMAARAGNAVHALLLYRHRLNRQEIPPVRGPQWVRDGGVVLWPLGHVGPG 305

  Fly   295 -----------MVQGMIPLCSWQYERTFNTARVPGLETDRIIHYRDSNHIVVLHKGCYYKMLIYY 348
                       ::.||.||||.|||:.|||.|:||::.|.|.|..||.|:.|.|:|.:::|..:.
Human   306 RQLTAHGFLQTLLMGMRPLCSAQYEKIFNTTRIPGVQKDYIRHLHDSQHVAVFHRGRFFRMGTHS 370

  Fly   349 KGRILRPCELQVQIEEILKGKATPVEGEEHLAALTAWNRSKWAEARNTFFSWGVNQTSLRT---- 409
            :..:|.|..|:.|.:.||...:.....|||||||||..|..||:.|          |||:|
Human   371 RNSLLSPRALEQQFQRILDDPSPACPHEEHLAALTAAPRGTWAQVR----------TSLKTQAAE 425

  Fly   410 ----IESAAFVLSLDDEPFEFDLARPEL-LDNFGKKLLHGNGYNRWFDKCFTVCVGTNGRVGFNA 469
                :|.|||.:|||.||.......|.. ||.:...||.|.|::|||||.||:.|.:||::|.:.
Human   426 ALEAVEGAAFFVSLDAEPAGLTREDPAASLDAYAHALLAGRGHDRWFDKSFTLIVFSNGKLGLSV 490

  Fly   470 EHTWSDAAIASHMWENLIVDDLVSDGYDETGNTKGTPAFQPPTPTRLTWDLKPCLAQIEEATIDV 534
            ||:|:|..|:.||||..:..:....||...|:.||.|....|.|.||.|||...:.......:..
Human   491 EHSWADCPISGHMWEFTLATECFQLGYSTDGHCKGHPDPTLPQPQRLQWDLPDQIHSSISLALRG 555

  Fly   535 TKLINE-VNLRILVHQDYGKGFMKKCRISPDAYIQMALQLAYYRDAGRFSLTYEASMTRLFREGR 598
            .|:::| |:..::....:||.|:::|.:|.|::||:|||||::||.|:|.||||::|||||.|||
Human   556 AKILSENVDCHVVPFSLFGKSFIRRCHLSSDSFIQIALQLAHFRDRGQFCLTYESAMTRLFLEGR 620

  Fly   599 TETVRPCTIESSAWVKAMQNPNTTNDERVKMMQAACDRHQLGYQDAMCGRGIDRHLFCLYVVSKY 663
            |||||.||.|:..:|:||::...|:.:.:.:.:.|.|:||...:.||.|:|:|||||.||:||::
Human   621 TETVRSCTREACNFVRAMEDKEKTDPQCLALFRVAVDKHQALLKAAMSGQGVDRHLFALYIVSRF 685

  Fly   664 LEVDSPFLNEVLSEPWRLSTSQTPHGQTPKMDLKKHPNCISAGGGFGPVADDGYGVSYIIAGENL 728
            |.:.||||.:|.||.|:|||||.|..|....|:..:|:.:|:||||||..|.|||||||..|:.:
Human   686 LHLQSPFLTQVHSEQWQLSTSQIPVQQMHLFDVHNYPDYVSSGGGFGPADDHGYGVSYIFMGDGM 750

  Fly   729 IFFHISAKTTCQQTDVHRFAQNISQALSDIRSMFE--QHMK 767
            |.||||:|.:..:||.||..|:|..||.|:.|:|:  ||.|
Human   751 ITFHISSKKSSTKTDSHRLGQHIEDALLDVASLFQAGQHFK 791

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
whd	NP_001163111.1	CPT_N	1..47	CDD:465132	20/45 (44%)
		Carn_acyltransf	174..753	CDD:459926	265/621 (43%)
CPT1C	NP_001365411.1	CPT_N	1..47	CDD:465132	20/45 (44%)
		Carn_acyltransf	174..775	CDD:459926	265/621 (43%)