DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Caf1-105 and CAC2

DIOPT Version :9

Sequence 1:	NP_610589.2	Gene:	Caf1-105 / 36107	FlyBaseID:	FBgn0033526	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_013605.1	Gene:	CAC2 / 854869	SGDID:	S000004570	Length:	468	Species:	Saccharomyces cerevisiae

Alignment Length:	450	Identity:	147/450 - (32%)
Similarity:	242/450 - (53%)	Gaps:	58/450 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 EISWHNRDPVLSVDIQQNGLGLRSPTICRLASGGSDAHVLIWYVNRSDDAE--GV----DVELAA 65
            :|.||:..||.|:..|:|...      .:|.:.|.|..|.||.:||.::.:  ||    .::...
Yeast     7 QIYWHDSQPVYSLTFQKNSAN------DKLFTAGGDNKVRIWKLNRDENGQNGGVRKIESLDFLG 65

  Fly    66 DLSRHQRAVNAVRWSPNGELLASGDDESVVFIWKQK----ADHEVVNI--VDADGC-SEQDKEVW 123
            .|:.|::|:|.:|::..|::|||..|:..|.:|||:    ....||..  :||:.. ::::||.|
Yeast    66 SLTHHEQAINVIRFNSKGDVLASAGDDGQVLLWKQEDPNTQQESVVRPFGMDAETSEADENKEKW 130

  Fly   124 LTLKVLRG-----HREDIYDLSWAPNSQFLVSGSVDNTAMLWDVHSGKSLAILDDHKGYVQGVAW 183
            :..|.|||     ...:||||:|:|:::.:|...:||:..|:||.:|..:....||..|||||||
Yeast   131 VVWKRLRGGSGATAAAEIYDLAWSPDNRNIVVACMDNSIRLFDVGAGMLVCGQSDHGHYVQGVAW 195

  Fly   184 DPCNQYIATMSTDRQMRIFD--------ANTKRVLHRVSKCVLPVKEDHEMHGKSMR---LYQDG 237
            ||.||:|.:.|.||.:.::.        ....::..:::|..||..      |..:|   |:.:.
Yeast   196 DPLNQFILSQSADRSLHVYGVILSSAGVVTGLKLRSKIAKAELPCP------GDVLRTNYLFHNE 254

  Fly   238 TLQTFFRRLCFTPDGKLLLTPSGITDYDGVVKPINTSYGFSRHDL--------SKPAFVLPFPKE 294
            ||.:||||...:|.|.|::.|||:....| .:..|..|.::|..:        ::||..:|..|:
Yeast   255 TLPSFFRRCSISPCGGLVVIPSGVYKVAG-DEVANCVYVYTRSGILNSAGGVKNRPAIRIPSLKK 318

  Fly   295 YAVAVRCSPVLYRLRPYNAEKNPPIISLPYRMIYAVATKNAVFFYDTQQPVPFAIVSNIHYSRLT 359
            .|:....|||.|.    ..:|:  ::.|||::::|:||.|.|..|||....|..:|.|||||.:|
Yeast   319 PALMAAFSPVFYE----TCQKS--VLKLPYKLVFAIATTNEVLVYDTDVLEPLCVVGNIHYSPIT 377

  Fly   360 DLAWSSDGTVLIVSSTDGYCSLITFE-PTELGDCYEDMETVLSVVLKSSENATVLKKKRQ 418
            |||||.||:.|::|||||:||.::.: .|:.|...|. ..:.:..|.:.|:|...|.:|:
Yeast   378 DLAWSEDGSTLLISSTDGFCSYVSIDTETQFGSRIEP-PAMHAEPLDTDESAVAAKNQRE 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Caf1-105	NP_610589.2	WD40	13..377	CDD:295369	132/400 (33%)
		WD40	67..446	CDD:225201	129/383 (34%)
		WD40 repeat	75..131	CDD:293791	20/62 (32%)
		WD40 repeat	136..172	CDD:293791	13/35 (37%)
		WD40 repeat	179..213	CDD:293791	13/41 (32%)
		WD40 repeat	243..290	CDD:293791	15/54 (28%)
		WD40 repeat	358..382	CDD:293791	16/23 (70%)
CAC2	NP_013605.1	WD40	4..214	CDD:421866	73/212 (34%)
		WD40 repeat	17..69	CDD:293791	14/57 (25%)
		WD40 repeat	74..141	CDD:293791	22/66 (33%)
		WD40	146..>410	CDD:421866	97/276 (35%)
		WD40 repeat	149..184	CDD:293791	12/34 (35%)
		WD40 repeat	190..252	CDD:293791	20/67 (30%)
		WD40 repeat	335..368	CDD:293791	13/34 (38%)
		WD40 repeat	376..402	CDD:293791	16/25 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346483
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1009
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	231	1.000	Inparanoid score	I728
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004789
OrthoInspector	1	1.000	-	-		oto99416
orthoMCL	1	0.900	-	-		OOG6_102357
Panther	1	1.100	-	-	LDO	PTHR15271
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1796
SonicParanoid	1	1.000	-	-		X3374
TreeFam	1	0.960	-	-
	12	11.780