DRSC/TRiP Functional Genomics Resources

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Protein Alignment Caf1-105 and HIR2

DIOPT Version :10

Sequence 1:NP_610589.2 Gene:Caf1-105 / 36107 FlyBaseID:FBgn0033526 Length:747 Species:Drosophila melanogaster
Sequence 2:NP_014681.1 Gene:HIR2 / 854203 SGDID:S000005564 Length:875 Species:Saccharomyces cerevisiae


Alignment Length:675 Identity:133/675 - (19%)
Similarity:239/675 - (35%) Gaps:195/675 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 HNRDPVLSVDIQQNGLGLRSPTICRLASGGSDAHVLIWYVNRSDDAEGVDVELAADLSRHQRAVN 75
            ||.        |.|.|....|.|....|||   ||:.|...:..|. ..|..:..||.  .....
Yeast    11 HNE--------QVNALAALGPYIILAGSGG---HVMAWRQQQLVDT-AFDRVMIKDLK--PEVSF 61

  Fly    76 AVRWSPNGEL-LASGDDESVVF-----IWKQKA----DHEVVNIVDADGCSEQDKEVWLTLKVLR 130
            .|.....|:: ..:||.|::..     :|....    |...:|.|:     :.:.::....|...
Yeast    62 QVDQDTTGDIFFITGDLETLYIGSEHRLWGYSGWLCRDTNNINSVE-----KMNSKLLFECKSPS 121

  Fly   131 GHREDIYDLSWAPNSQFLVSGSVDNTAMLWDVHSGKSLAILDDHKGY--------------VQGV 181
            ...:..||:               |..:|:.:.|.::..:|..||.:              :.|:
Yeast   122 TITDVKYDI---------------NLGILFVLLSNENKILLFRHKTFDKLSEITIDKASKPITGI 171

  Fly   182 AWDPCNQYIATMSTDRQMRIFDAN---TKRVLHRVSKCVLPVKEDHEMHGKSMRLYQDGTLQTFF 243
            . ||..|....|::||.:.::..|   |.::::::::.|    :.:.:|                
Yeast   172 I-DPTGQTFTVMTSDRSILVYQINKTGTHKLINKLTQHV----QMYPLH---------------- 215

  Fly   244 RRLCFTPDGKLLL-------TPSGITDYDGVVKPINTSYGFSRHDLSKPAFVLPFPKEYAVAVRC 301
            .|:..:|...:|.       .|:..|....::.. |.:|..::      ..|.|......|.| .
Yeast   216 YRISMSPQADILPVINSVKGVPNNATSCTALLDR-NNNYKVTK------TLVTPSSNGCRVLV-Y 272

  Fly   302 SPVLYRLRPYNAEKNPPIISLPYRMI-YAVATKNAVFFYDTQQPVPFAIVSNIHYSRLTDLAWSS 365
            ||..|. :| |.:|.   .|..|.:| .:.:|...:..::|::..|......:..:.:.|::||.
Yeast   273 SPAFYE-KP-NLKKG---TSTRYNLIATSGSTDGTILVWNTKRMKPLFNALQVSSTAINDMSWSQ 332

  Fly   366 DGTVLIVSSTDGYCSLITFEPTELGDCYEDMETVLSVVLKSSENATVLKKKRQKLRKVSLDEPRK 430
            ||..|...|.|.......|:..:||           |.|..:|..: |::..:||.|  |:||..
Yeast   333 DGFTLFAISNDATLYTFAFQEKDLG-----------VALPQTEIKS-LQEVNKKLPK--LEEPLA 383

  Fly   431 PLQEKSKPNTIR---RASEAGI-TEVGEPELDAENDSSTHSVSSNKTNSPKT-KASEEEKPTPIA 490
            ....||.|..|:   .||.|.| .::|...:..:  .:....::|:||..|| :::..|..||  
Yeast   384 EQIPKSFPENIKLEESASAAPIPNDIGRSAVGKK--PTKKKTANNQTNGIKTIQSTSMEFNTP-- 444

  Fly   491 IRRSPRKNSTAPMPIAIRRAPRKPEDKGNSESSKPKDEMEVTHTKTTQVQKTVASPVKRKVSTEA 555
                   :.|.|     |...|||::                           |:|      :..
Yeast   445 -------SYTVP-----RDLKRKPKE---------------------------ATP------SNI 464

  Fly   556 VPPAETSQPALAVIPVFEKEIISSDDKFESPEKKSRPATPIQVRRQPRTPGSSSQFNLTPKSQP- 619
            .|.::..:..|..|...:..::..:..|    .:.|.||| ::|         |.|..:|.:.| 
Yeast   465 APGSKKQKKELQPIDFLDTGLLLPNTSF----SRIRLATP-KIR---------STFKYSPINNPN 515

  Fly   620 ---------AKQATPIAVRRTPRVL 635
                     ..:..|..|:.|.:||
Yeast   516 LILDVKNGSGNEQRPTIVKLTSKVL 540

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Caf1-105NP_610589.2 WD40 <4..377 CDD:441893 76/400 (19%)
WD40 repeat 75..131 CDD:293791 10/65 (15%)
WD40 repeat 136..172 CDD:293791 5/35 (14%)
WD40 repeat 179..213 CDD:293791 9/36 (25%)
WD40 repeat 243..290 CDD:293791 8/53 (15%)
WD40 repeat 358..382 CDD:293791 8/23 (35%)
PHA03247 <472..742 CDD:223021 33/175 (19%)
HIR2NP_014681.1 WD40 repeat 123..163 CDD:293791 8/54 (15%)
WD40 repeat 169..207 CDD:293791 9/38 (24%)
WD40 <172..350 CDD:475233 41/211 (19%)
WD40 repeat 268..318 CDD:293791 14/55 (25%)
Hira 581..824 CDD:462211
Blue background indicates that the domain is not in the aligned region.

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