DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Caf1-105 and FAS2

DIOPT Version :9

Sequence 1:	NP_610589.2	Gene:	Caf1-105 / 36107	FlyBaseID:	FBgn0033526	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_974991.1	Gene:	FAS2 / 836584	AraportID:	AT5G64630	Length:	487	Species:	Arabidopsis thaliana

Alignment Length:	544	Identity:	180/544 - (33%)
Similarity:	272/544 - (50%)	Gaps:	98/544 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKCKIPEISWHNRDPVLSVDIQQ-NGLGLRSPTICRLASGGSDAHVLIWYVNRSDDAEGV-DVEL 63
            ||....:||||:..|||:||... :||         ||:.|:|..:.:|.:|.....:.| .|..
plant     1 MKGGTIQISWHDGKPVLTVDFHPISGL---------LATAGADYDIKLWLINSGQAEKKVPSVSY 56

  Fly    64 AADLSRHQRAVNAVRWSPNGELLASGDDESVVFIWKQKADHEVVNIVDADGCSEQDKEVWLTLKV 128
            .:.|:.|..|||.:|:||:|||||||.|...:||||..              ..:..:.|...|.
plant    57 QSSLTYHGCAVNTIRFSPSGELLASGADGGELFIWKLH--------------PSETNQSWKVHKS 107

  Fly   129 LRGHREDIYDLSWAPNSQFLVSGSVDNTAMLWDVHSGKSLAILDDHKGYVQGVAWDPCNQYIATM 193
            |..||:|:.||.|:|:..:|:||||||:.::|||:.|....|||.|..|||||||||..:|:|::
plant   108 LSFHRKDVLDLQWSPDDAYLISGSVDNSCIIWDVNKGSVHQILDAHCHYVQGVAWDPLAKYVASL 172

  Fly   194 STDRQMRIFDANTKRVLHRVSK----CVLPVKEDHEMHGKSMR-----LYQDGTLQTFFRRLCFT 249
            |:||..||:....:.....|.|    |...:.:..:..|...:     |:.|.||.:|||||.::
plant   173 SSDRTCRIYANKPQTKSKGVEKMNYVCQHVIMKADQQRGDETKTIKTHLFHDETLPSFFRRLSWS 237

  Fly   250 PDGKLLLTPSGITDYDGVVKPINTSYGFSRHDLSKPAFVLPFPKEYAVAVRCSPVLYRLRPYNAE 314
            |||..||.|:|........:.:|.:|.|||.|||:||..||...:..|.||..||.::||..::|
plant   238 PDGSFLLIPAGSFKVSPTSEAVNATYVFSRKDLSRPALQLPGASKPVVVVRFCPVAFKLRGSSSE 302

  Fly   315 KNPPIISLPYRMIYAVATKNAVFFYDTQQPVPFAIVSNIHYSRLTDLAWSSDGTVLIVSSTDGYC 379
            :.  ...||||:::|:||.|:|:.|||:...|.|:::.:||:.:||:.||.:.:.|.:||.||||
plant   303 EG--FFKLPYRLVFAIATLNSVYIYDTECVAPIAVLAGLHYAAITDITWSPNASYLALSSQDGYC 365

  Fly   380 SLITFEPTELGDCYEDMETVLSVVLKSSENATVLKKKRQKLRKVSLDEPRKPLQEKSKPNTIRRA 444
            :|:.||..|||:.                              ||:...:||:..:.|.:.:.:.
plant   366 TLVEFEDKELGEA------------------------------VSISVGKKPVDGEEKKHDLEKG 400

  Fly   445 SEAGITEV------GEPELDAENDSSTHSVSSNKTNSPK----------------TKASEEEKP- 486
            .|. :||.      .:.||: :|:.|...:.|..|...|                |:..||.:|
plant   401 DEL-MTETTPDESKKQAELE-QNEESKQPLPSKITTDGKEKEHIMQKTDDEVMTETRHEEENQPL 463

  Fly   487 -----TPIAIRRSPRKNSTAPMPI 505
                 ||::  ..|.:....||.|
plant   464 QSKVNTPVS--NKPARKRITPMAI 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Caf1-105	NP_610589.2	WD40	13..377	CDD:295369	139/374 (37%)
		WD40	67..446	CDD:225201	139/387 (36%)
		WD40 repeat	75..131	CDD:293791	19/55 (35%)
		WD40 repeat	136..172	CDD:293791	16/35 (46%)
		WD40 repeat	179..213	CDD:293791	14/33 (42%)
		WD40 repeat	243..290	CDD:293791	21/46 (46%)
		WD40 repeat	358..382	CDD:293791	11/23 (48%)
FAS2	NP_974991.1	WD40	14..363	CDD:392136	139/373 (37%)
		WD40 repeat	16..62	CDD:293791	15/54 (28%)
		WD40 repeat	68..110	CDD:293791	19/55 (35%)
		WD40 repeat	115..151	CDD:293791	16/35 (46%)
		WD40 repeat	158..191	CDD:293791	14/32 (44%)
		WD40 repeat	274..337	CDD:293791	25/64 (39%)
		WD40 repeat	344..367	CDD:293791	11/22 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1009
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48346
Inparanoid	1	1.050	287	1.000	Inparanoid score	I845
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D685536at2759
OrthoFinder	1	1.000	-	-		FOG0004789
OrthoInspector	1	1.000	-	-		oto2994
orthoMCL	1	0.900	-	-		OOG6_102357
Panther	1	1.100	-	-	LDO	PTHR15271
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3374
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.830