DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Caf1-105 and HIRA

DIOPT Version :9

Sequence 1:	NP_610589.2	Gene:	Caf1-105 / 36107	FlyBaseID:	FBgn0033526	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_190039.2	Gene:	HIRA / 823578	AraportID:	AT3G44530	Length:	1058	Species:	Arabidopsis thaliana

Alignment Length:	694	Identity:	176/694 - (25%)
Similarity:	283/694 - (40%)	Gaps:	130/694 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 W--HNRDPVLSVDIQQNGLGLRSPTICRLASGGSDAHVLIWYVNRSD-DAEGVDVE--LAADLSR 69
            |  |....:.|:|:|.||.        |.|:||.|..|.||.:...| |.:.:|.:  |.|.|..
plant     8 WVKHEGLQIFSIDVQPNGE--------RFATGGGDHKVRIWNMKSVDKDLQNIDTKERLLATLRD 64

  Fly    70 HQRAVNAVRWSPNGELLASGDDESVVFIWKQKADHEVVNIVDADGCSE-QDKEVWLTLKVLRGHR 133
            |..:||.|||:.|...:|||.|:.|:.|.::|........    |..| .|.|.|..:..||||.
plant    65 HFGSVNCVRWAKNSRYVASGSDDQVIQIHERKPGSGTTEF----GSGEAPDVENWKAVMTLRGHT 125

  Fly   134 EDIYDLSWAPNSQFLVSGSVDNTAMLWDVHSGKSLAILDDHKGYVQGVAWDPCNQYIATMSTDRQ 198
            .|:.||:|:|:...|.|||:|||..:|::.:|....:|..|...|:||.|||...:||:.|.|:.
plant   126 ADVVDLNWSPDDSMLASGSLDNTVHIWNMRTGMCTTVLRGHLSLVKGVTWDPIGSFIASQSDDKT 190

  Fly   199 MRIFDANTKRVLHRVSKCVLPVKEDHEMHGKSMRLYQDGTLQTFFRRLCFTPDGKLLLTPSGITD 263
            :.|:..:...:.||.        :.|  ..||:.       .||||||.::|.|..|.|..|..
plant   191 VIIWRTSDWGMAHRT--------DGH--WAKSLG-------STFFRRLGWSPCGHFLTTTHGFQ- 237

  Fly   264 YDGVVKPINT-----------SYGFSRHDLSKPAFVLPFPKEYAVAVRCSPVLYRLRPY------ 311
                 ||.::           :|.|..|  |.|..|:.|  .:::..|.....:..:..
plant   238 -----KPKHSAPVLERGEWSVAYDFLGH--SAPIIVVRF--NHSMFKRIPSSTHETKQVGWSNGT 293

  Fly   312 --NAEKNPPIISLPYRMIYAVATKNAVFFYDTQQPVPFAIVSNIHYSRLTDLAWSSDGTVLIVSS 374
              :.||:    ...|.:|...:....:..:.|....|..:..:.....:.||:||.||..|...|
plant   294 SKSGEKD----LQSYNVIAMGSQDRTITVWTTGSARPLFVAKHFFGQSVVDLSWSPDGYSLFACS 354

  Fly   375 TDGYCSLITFEPTELGDCYEDMETVLSVVLKSSENATVLKKKRQ---KLRKVSL-DEPRKPLQEK 435
            .||..::|.|:|.|||....|.|            ...|||.|.   :.|:.:| :.|.:.|.|.
plant   355 LDGTVAMIHFDPKELGVRLTDTE------------LDELKKSRYGDVRGRQANLVESPAQLLLET 407

  Fly   436 SKPNTIRRASEAGITEVGEPELDAENDSSTHSVSSNKTN--SPKTKASEEEKPTPIAIRRSPRKN 498
            :  :|.:..|:...::|.:.::..:...|..|.:..:.:  ..:.||:|....|  ..:.|....
plant   408 A--STKQAGSKRAASDVQQNQVTTKPSVSVESTAKRRKSQVDDRNKAAESTGQT--LNKASTLNR 468

  Fly   499 STAPMPIAIRRAP--RK---PEDKGNSESSKPKDEMEVTHTKTTQ--VQKTVASPVKRKVSTEAV 556
            .::|:...:.|.|  ||   ||..|     .|:.|..:.....:.  :..:.|:|.|   .....
plant   469 VSSPVNQKVYRRPDGRKRIIPEAVG-----VPQQENNIMINGESHNFLPASAAAPAK---GDSGD 525

  Fly   557 PPAETSQPALAVIPVFEKEIISSDDKFESPEKKSRPAT---PIQVRRQPRTPGSSSQFNLTPKSQ 618
            .|.|.|...|:     .|||:..:...:...:.:..||   .:.:.:.|.|.|.....|:
plant   526 FPVEISNRDLS-----GKEIVCRNPDLKERSRITARATITESLVIEKVPGTSGRDGVLNV----- 580

  Fly   619 PAKQATPIAVRRTPRVLIEM----------PVNSPVVPMEEAMD 652
              :|:..|....:..:||.:          ||.....|.|.|:|
plant   581 --EQSVGIKESSSTDLLIRVFDWKDGEAAPPVCLEACPREHALD 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Caf1-105	NP_610589.2	WD40	13..377	CDD:295369	109/386 (28%)
		WD40	67..446	CDD:225201	111/402 (28%)
		WD40 repeat	75..131	CDD:293791	18/56 (32%)
		WD40 repeat	136..172	CDD:293791	13/35 (37%)
		WD40 repeat	179..213	CDD:293791	11/33 (33%)
		WD40 repeat	243..290	CDD:293791	17/57 (30%)
		WD40 repeat	358..382	CDD:293791	10/23 (43%)
HIRA	NP_190039.2	WD40	4..359	CDD:225201	113/393 (29%)
		WD40	11..359	CDD:238121	112/390 (29%)
		WD40 repeat	16..64	CDD:293791	19/55 (35%)
		WD40 repeat	70..123	CDD:293791	18/56 (32%)
		WD40 repeat	128..164	CDD:293791	13/35 (37%)
		WD40 repeat	171..206	CDD:293791	12/42 (29%)
		WD40 repeat	264..331	CDD:293791	9/72 (13%)
		WD40 repeat	338..362	CDD:293791	10/23 (43%)
		Hira	680..907	CDD:284895
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D685536at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920