DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Caf1-105 and HIRA

DIOPT Version :9

Sequence 1:	NP_610589.2	Gene:	Caf1-105 / 36107	FlyBaseID:	FBgn0033526	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_003316.3	Gene:	HIRA / 7290	HGNCID:	4916	Length:	1017	Species:	Homo sapiens

Alignment Length:	753	Identity:	176/753 - (23%)
Similarity:	317/753 - (42%)	Gaps:	143/753 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KIPEISW--HNRDPVLSVDIQQNGLGLRSPTICRLASGG---SDAHVLIWYVN---RSDDAEGVD 60
            |:.:.:|  ||..|:.||||..:|        .:.|:||   ....|:||.::   :.||.:..:
Human     2 KLLKPTWVNHNGKPIFSVDIHPDG--------TKFATGGQGQDSGKVVIWNMSPVLQEDDEKDEN 58

  Fly    61 V-ELAADLSRHQRAVNAVRWSPNGELLASGDDESVVFIWKQKADHEVVNIVDADGCSEQDKEVWL 124
            : ::...:..|...||.||||.:|..||||.|:.::.:|| :|.:...:.|........:.|.|.
Human    59 IPKMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWK-RATYIGPSTVFGSSGKLANVEQWR 122

  Fly   125 TLKVLRGHREDIYDLSWAPNSQFLVSGSVDNTAMLWD-VHSGKSLAILDDHKGYVQGVAWDPCNQ 188
            .:.:||.|..|:.|::|:|:..:|.|.|||||.::|: |...:.||.|..|.|.|:|:.|||..:
Human   123 CVSILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGK 187

  Fly   189 YIATMSTDRQMRIFDANTKRVLHRVSKCVLPVKEDHEMHGKSMRLYQDGTLQTFFRRLCFTPDGK 253
            |||:.:.||.::::     |.|            |.::.....:.:.:....|...||.::|||.
Human   188 YIASQADDRSLKVW-----RTL------------DWQLETSITKPFDECGGTTHVLRLSWSPDGH 235

  Fly   254 LLLTPSGITDYDGVVKPI-----NTSYGFSRHDLSKPAFVLPFPKEYAVAVRCSPVLYRLRPYNA 313
            .|::...:.:.....:.|     .|:..|..|            ::....|:.:|.:::.:..|.
Human   236 YLVSAHAMNNSGPTAQIIEREGWKTNMDFVGH------------RKAVTVVKFNPKIFKKKQKNG 288

  Fly   314 EKNPPIISLPYRMIYAVATKN-AVFFYDTQQPVPFAIVSNIHYSRLTDLAWSSDGTVLIVSSTDG 377
            ....|  |.|| ...||.:|: ::..:.|....|..::..:....:.|::|:.:|..::|.|.||
Human   289 SSAKP--SCPY-CCCAVGSKDRSLSVWLTCLKRPLVVIHELFDKSIMDISWTLNGLGILVCSMDG 350

  Fly   378 YCSLITFEPTELGDCYEDME----------TVLSVVLKSS------ENATVLKKKRQKLRKVSLD 426
            ..:.:.|...||||...:.|          ..|:::.::.      ||..:||.:|:: ::..||
Human   351 SVAFLDFSQDELGDPLSEEEKSRIHQSTYGKSLAIMTEAQLSTAVIENPEMLKYQRRQ-QQQQLD 414

  Fly   427 EPRKPLQEKSKPNTIRRASEAGITEVGEPELDAENDSSTHSVSSN--KTNSPKTKASEEEKPTPI 489
            :.....:|.....::     ||:.          |..|...:..|  |.......|....:.||:
Human   415 QKSAATREMGSATSV-----AGVV----------NGESLEDIRKNLLKKQVETRTADGRRRITPL 464

  Fly   490 AIRR-------------SPRKNSTAPMPIAIRRAPR-KPEDKGNSES---SKPKDEMEVTHTKTT 537
            .|.:             .|...|.|...::...:|: .|.|.....|   |||..|..|..:
Human   465 CIAQLDTGDFSTAFFNSIPLSGSLAGTMLSSHSSPQLLPLDSSTPNSFGASKPCTEPVVAAS--- 526

  Fly   538 QVQKTVASPVKRKVSTEAVPPAETSQPALAVIPVFEKEIISSDDKFESPEKKSRPATPIQVR--- 599
                  |.|....|:.:::  ..||.|| |:.|    .::::..|.|       |......|
Human   527 ------ARPAGDSVNKDSM--NATSTPA-ALSP----SVLTTPSKIE-------PMKAFDSRFTE 571

  Fly   600 RQPRTPGSSSQFNLTPKSQPAKQATPIAVRRTPRVLIEMPVNS-PVVPMEEA--MDAWPLDESIT 661
            |...|||:.:..::||.:....:...:.....||.|:|...:| ..||:.:|  :....|:..:.
Human   572 RSKATPGAPALTSMTPTAVERLKEQNLVKELRPRDLLESSSDSDEKVPLAKASSLSKRKLELEVE 636

  Fly   662 PLPATK-----KDSRKPLPETVKTETKPAVIEASEATC 694
            .:...|     ||||. :|.::..::..|:....||.|
Human   637 TVEKKKKGRPRKDSRL-MPVSLSVQSPAALTAEKEAMC 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Caf1-105	NP_610589.2	WD40	13..377	CDD:295369	95/377 (25%)
		WD40	67..446	CDD:225201	98/401 (24%)
		WD40 repeat	75..131	CDD:293791	18/55 (33%)
		WD40 repeat	136..172	CDD:293791	14/36 (39%)
		WD40 repeat	179..213	CDD:293791	11/33 (33%)
		WD40 repeat	243..290	CDD:293791	10/51 (20%)
		WD40 repeat	358..382	CDD:293791	7/23 (30%)
HIRA	NP_003316.3	WD40	<7..372	CDD:225201	106/405 (26%)
		WD40	7..352	CDD:238121	100/385 (26%)
		WD 1	11..53		14/49 (29%)
		WD40 repeat	16..61	CDD:293791	13/52 (25%)
		WD 2	68..107		16/39 (41%)
		WD40 repeat	74..129	CDD:293791	18/55 (33%)
		WD 3	129..168		14/38 (37%)
		WD40 repeat	134..171	CDD:293791	14/36 (39%)
		WD 4	172..211		15/55 (27%)
		WD40 repeat	178..213	CDD:293791	12/51 (24%)
		WD 5	220..263		9/42 (21%)
		WD40 repeat	226..265	CDD:293791	8/38 (21%)
		WD 6	266..322		13/70 (19%)
		WD40 repeat	273..324	CDD:293791	12/53 (23%)
		WD 7	326..367		12/40 (30%)
		WD40 repeat	331..354	CDD:293791	7/22 (32%)
		Interaction with CCNA1. /evidence=ECO:0000269\|PubMed:11238922	421..729		61/292 (21%)
		Interaction with ASF1A	421..479		11/72 (15%)
		Required for repression of histone gene transcription	439..475		6/35 (17%)
		HIRA_B	448..469	CDD:286531	4/20 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	494..555		18/76 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	570..589		6/18 (33%)
		Interaction with histone H2B	593..826		19/82 (23%)
		Interaction with PAX3. /evidence=ECO:0000250	594..739		19/81 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	604..625		8/20 (40%)
		Mcl1_mid	<727..>795	CDD:289138
		Interaction with histone H4	738..1017
		Interaction with PAX3. /evidence=ECO:0000250	740..828
		Hira	763..954	CDD:284895
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D366817at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920