DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Caf1-105 and chaf1b

DIOPT Version :9

Sequence 1:	NP_610589.2	Gene:	Caf1-105 / 36107	FlyBaseID:	FBgn0033526	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_001315058.1	Gene:	chaf1b / 406285	ZFINID:	ZDB-GENE-040426-1947	Length:	613	Species:	Danio rerio

Alignment Length:	655	Identity:	241/655 - (36%)
Similarity:	356/655 - (54%)	Gaps:	72/655 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKCKIPEISWHNRDPVLSVDIQQNGLGLRSPTICRLASGGSDAHVLIWYVNRSDDAEGVDVELAA 65
            ||....||:|||::||.|:|.||:|.|...    |||:.|.|..|.:|.|::..|.:.| ||..:
Zfish     1 MKVVTCEIAWHNKEPVYSLDFQQSGDGKTQ----RLATAGVDTTVRMWRVDKGPDGKAV-VEFLS 60

  Fly    66 DLSRHQRAVNAVRWSPNGELLASGDDESVVFIWK--QKADHEVVNIVDADGCSEQDKEVWLTLKV 128
            :|:||.:|||.||:||..|:||||.|::.:.:||  ...:.|.......:..::.:||.|..:|.
Zfish    61 NLARHTKAVNVVRFSPTAEVLASGGDDAAILLWKLNDNKEPEQTPTFQEEEDAQLNKESWSVVKT 125

  Fly   129 LRGHREDIYDLSWAPNSQFLVSGSVDNTAMLWDVHSGKSLAILDDHKGYVQGVAWDPCNQYIATM 193
            ||||.||:||:||..:..|:.||||||||::|||:.|:.:.|.:|||.|||||||||..|||:|:
Zfish   126 LRGHIEDVYDISWTSDGNFMASGSVDNTAIMWDVNKGQKMCIFNDHKSYVQGVAWDPLGQYISTL 190

  Fly   194 STDRQMRIFDANTKRVLHRVSKCVLPVKEDHEMHGKSMRLYQDGTLQTFFRRLCFTPDGKLLLTP 258
            |.||.||::.|:.::..:.:||.......|.|:  |:.|::.|.::::|||||.|||||..||.|
Zfish   191 SCDRVMRVYSAHNRKKAYSISKMTSSATADGEV--KNYRMFHDDSMRSFFRRLTFTPDGSFLLAP 253

  Fly   259 SGITDYDGVVKPINTSYGFSRHDLSKPAFVLPFPKEYAVAVRCSPVLYRLRPYNAEKN--PPI-- 319
            :|..:....|  .||:|.|||....:|...||.|.:..:|||||||.:.||...||.:  .|:
Zfish   254 AGCVEAGENV--TNTTYVFSRKSFKRPIAHLPCPSKATLAVRCSPVYFELRTKRAEDDSLKPVAN 316

  Fly   320 -ISLPYRMIYAVATKNAVFFYDTQQPVPFAIVSNIHYSRLTDLAWSSDGTVLIVSSTDGYCSLIT 383
             .:||||:::|||:::::|||||||.:||..||||||..|:||:||.||:.|.|||||||||.|:
Zfish   317 TFNLPYRLVFAVASEDSIFFYDTQQTLPFGYVSNIHYHTLSDLSWSRDGSFLAVSSTDGYCSFIS 381

  Fly   384 FEPTELGDCYEDMETVLSVVLKSSENATVLKKKRQKLR--KVSLDEPRK----PLQEKSK----- 437
            |:..|||...:: :..|.:|..||.|.   ||.::.|.  :.:...||:    ..|:|.|
Zfish   382 FDEGELGTPLKE-KPPLEMVTPSSTNE---KKGKRALANGRTASPVPRQANTPAAQDKEKEGSAG 442

  Fly   438 PNTIRRASEAGITEVGEPELDAENDSSTHSVSSN------KTNSPKTKASEEEKPTPIAIRRSPR 496
            |.:.:.:|.:|..|...|:. .:..:....::.|      |.::||:.|: .....|...:.:|.
Zfish   443 PASSKTSSVSGTEEKRTPQA-LKTKAQPRRITLNTLEGWGKPSTPKSPAA-ASSTAPSTPKSAPS 505

  Fly   497 KNSTAPMPIAIRRAPRKPEDKGNSESSKPKDEMEVTHTKTTQVQKTVASPVKRKVSTEAVPPAET 561
            ...::..|:....||..|....||::.        |..|....::...:||..|.....|||:.|
Zfish   506 TPGSSRAPLTPHTAPSTPLGPLNSKNG--------TTPKGPTPRRISLTPVVSKSPAAFVPPSST 562

  Fly   562 SQPALAVIPVFEKEIISSDDKFESPEKKSRPA--TPIQVRRQPRTPGSSSQFNLTPKSQPAKQAT 624
            .:.                 |.|.|...|.||  .|...|.:...|..|.|      |...|:||
Zfish   563 EKA-----------------KHERPSPSSDPACKPPESKRSKTDVPDGSVQ------SSKNKEAT 604

  Fly   625 PIAVR 629
            .|.|:
Zfish   605 EITVK 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Caf1-105	NP_610589.2	WD40	13..377	CDD:295369	167/370 (45%)
		WD40	67..446	CDD:225201	171/396 (43%)
		WD40 repeat	75..131	CDD:293791	19/57 (33%)
		WD40 repeat	136..172	CDD:293791	18/35 (51%)
		WD40 repeat	179..213	CDD:293791	17/33 (52%)
		WD40 repeat	243..290	CDD:293791	21/46 (46%)
		WD40 repeat	358..382	CDD:293791	17/23 (74%)
chaf1b	NP_001315058.1	WD40	10..>386	CDD:225201	177/384 (46%)
		WD40	11..375	CDD:295369	169/372 (45%)
		WD40 repeat	70..128	CDD:293791	19/57 (33%)
		WD40 repeat	133..169	CDD:293791	18/35 (51%)
		WD40 repeat	176..203	CDD:293791	17/26 (65%)
		WD40 repeat	238..272	CDD:293791	18/35 (51%)
		WD40 repeat	290..352	CDD:293791	31/61 (51%)
		CAF-1_p60_C	388..596	CDD:292150	51/238 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595869
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1009
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48346
Inparanoid	1	1.050	383	1.000	Inparanoid score	I2005
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D366817at33208
OrthoFinder	1	1.000	-	-		FOG0004789
OrthoInspector	1	1.000	-	-		oto41410
orthoMCL	1	0.900	-	-		OOG6_102357
Panther	1	1.100	-	-	LDO	PTHR15271
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1796
SonicParanoid	1	1.000	-	-		X3374
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.830