Protein Alignment Caf1-105 and hira-1

DIOPT Version :10

• Sequence 1: NP_610589.2
• Gene: Caf1-105 / 36107
• FlyBaseID: FBgn0033526
• Length: 747
• Species: Drosophila melanogaster
• Sequence 2: NP_498101.2
• Gene: hira-1 / 175709
• WormBaseID: WBGene00019627
• Length: 935
• Species: Caenorhabditis elegans
• Alignment Length: 760
• Identity: 174/760 - (22%)
• Similarity: 298/760 - (39%)
• Gaps: 192/760 - (25%)

  Fly     6 PEISWHNRDPVLSVDIQQNGLGLRSPTICRLASGGSDAHVLIWYVNRSDDAEGV-DVELAADLS- 68
            |....|:...:|::|...:|   :....|...:..|:..|::|      :||.| |.:.|::.:
 Worm     9 PTFVGHDTGSILAIDCHPSG---KKFITCGQKARTSNGLVVVW------NAEPVLDKKKASNENV 64

  Fly    69 -------RHQRAVNAVRWSPNGELLASGDDESVVFIWKQKADHEVVNIVDADGC---SEQDKEVW 123
                   ..|...|:.||||:|:..|.|.|:|.|.:|      |.|.::::.|.   ..|:.|.:
 Worm    65 PKLLFQVESQSQSNSCRWSPDGKRFAFGSDDSSVSVW------EYVGLINSMGSITGGAQNVERY 123

  Fly   124 LTLKVLRGHREDIYDLSWAPNSQFLVSGSVDNTAMLWDVHS-GKSLAILDDHKGYVQGVAWDPCN 187
            ....|||||..::..:.|:||.::|.|||:|...::::... ...:.:|:|.:..|:|::|||..
 Worm   124 KECCVLRGHSMEVLTVEWSPNGKYLASGSIDYRIIIYNARKLPDRITVLNDIQLPVKGLSWDPIG 188

  Fly   188 QYIATMSTDRQMRIFDANTKRVLHRVSKCVLPVKEDHEMHGKSMRLYQDGTLQTFFRRLCFTPDG 252
            :|:|::..|:::|.:..::       .:||..|.|.          ::....:|...||.::|||
 Worm   189 KYLASLEGDKKLRFWATDS-------WQCVKSVTEP----------FESNIEETMLTRLDWSPDG 236

  Fly   253 KLLLTPSGITDYDGVVKPINTSYGFSRHDLSKPAFVLPFPKEYAVAVRCSPVLYRLRPYNAEKNP 317
            |.|:||:.:.....::|.|      .|.......|:....|. ...||..|.|......|.::..
 Worm   237 KYLMTPAAVRSGKPLIKLI------QRQTWKSDQFLAGHHKG-TTCVRAMPRLIEANLKNGKRMQ 294

  Fly   318 PIISLPYRMIYAVATKNAVF----FYDTQQPVPFAIVSNIHYSRLTDLAWSSDGTVLIVSSTDGY 378
            ...:       ||.:::...    |..|.:|:  .:::||....:.|.||.  |..|:..|.||.
 Worm   295 LTCA-------AVGSRDKSISIWVFPGTLKPL--FVINNIFNHTVMDFAWC--GRNLLACSQDGT 348

  Fly   379 CSLITFEPTELGD----------CYE------------DMET-------VLSVVLKSSENAT--- 411
            ..:|....:.:|:          ||:            |.|.       .||.:..|:.||:
 Worm   349 VKVIHLSESVIGEMISNEAMSDLCYQIYSIRPPRYELTDKEEDESQDSFNLSDLSSSANNASFVT 413

  Fly   412 -----VLKKKRQKLRKVSLD-EPRKPLQEKSKPNTIRRASEAGITEVGEPELDAENDSSTH---S 467
                 ::|:|:....:.|.| :..|.:::.||.|..:. ||..:.|....::|...|....   .
 Worm   414 CPEDVLIKRKKLVAAQQSSDIQLTKSMEDNSKENESKN-SEKTMMEERNKQIDVRKDGKRRIQPV 477

  Fly   468 VSSNKTNSPKTKASEEEKPTPIAIRRSPRKNSTAPMPIAIRR--APRKPEDKG-----NSESSKP 525
            .....|..|.|..|.|.|.|            .||.| |.|:  ||..|..||     :|..|..
 Worm   478 FCGTTTADPMTSLSSEGKKT------------VAPPP-AKRKALAPAVPAKKGEVDLEDSSDSDD 529

  Fly   526 KDEMEVTHTKTTQVQKTVASPVKRKVSTEAVPPAETSQPALAVIPVFEKEIISSDDKFESPEKKS 590
            .||.|....:.:.::.  ....||||      ||.||||.||:                  :.|.
 Worm   530 DDEEEEEDMEISDIES--VRNKKRKV------PATTSQPMLAL------------------DLKK 568

  Fly   591 RPATPIQVRRQPRTPGSSSQFNLTPKSQPAKQATPIAVRRTPRVLIEMPVNSPVVPMEEAMDAWP 655
            ....|::                 |||...::.|         ||:|.|...|.: .:..:|...
 Worm   569 PALRPME-----------------PKSLKTQEGT---------VLMEAPEQQPKL-SQHVVDRKG 606

  Fly   656 LDESITPLPATKKDSRKPLPETVKTETKPAVIEASEATCERTEDI 700
            :...|        |:|........|:.|  :|:..:.|.|..:|:
 Worm   607 MFVEI--------DNRWKHGGVETTQIK--LIKKKQQTAENEDDM 641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Caf1-105	NP_610589.2	WD40	<4..377	CDD:441893	93/387 (24%)
		WD40 repeat	75..131	CDD:293791	19/58 (33%)
		WD40 repeat	136..172	CDD:293791	8/36 (22%)
		WD40 repeat	179..213	CDD:293791	8/33 (24%)
		WD40 repeat	243..290	CDD:293791	13/46 (28%)
		WD40 repeat	358..382	CDD:293791	8/23 (35%)
		PHA03247	<472..742	CDD:223021	55/236 (23%)
hira-1	NP_498101.2	WD40	<10..351	CDD:441893	94/390 (24%)
		WD40 repeat	19..71	CDD:293791	12/60 (20%)
		WD40 repeat	79..131	CDD:293791	18/57 (32%)
		WD40 repeat	137..174	CDD:293791	9/36 (25%)
		WD40 repeat	179..219	CDD:293791	13/56 (23%)
		WD40 repeat	227..267	CDD:293791	13/45 (29%)
		WD40 repeat	274..321	CDD:293791	10/55 (18%)
		Hira	695..885	CDD:462211