DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Caf1-105 and hira-1

DIOPT Version :9

Sequence 1:	NP_610589.2	Gene:	Caf1-105 / 36107	FlyBaseID:	FBgn0033526	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_498101.2	Gene:	hira-1 / 175709	WormBaseID:	WBGene00019627	Length:	935	Species:	Caenorhabditis elegans

Alignment Length:	760	Identity:	174/760 - (22%)
Similarity:	298/760 - (39%)	Gaps:	192/760 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PEISWHNRDPVLSVDIQQNGLGLRSPTICRLASGGSDAHVLIWYVNRSDDAEGV-DVELAADLS- 68
            |....|:...:|::|...:|   :....|...:..|:..|::|      :||.| |.:.|::.:
Worm     9 PTFVGHDTGSILAIDCHPSG---KKFITCGQKARTSNGLVVVW------NAEPVLDKKKASNENV 64

  Fly    69 -------RHQRAVNAVRWSPNGELLASGDDESVVFIWKQKADHEVVNIVDADGC---SEQDKEVW 123
                   ..|...|:.||||:|:..|.|.|:|.|.:|      |.|.::::.|.   ..|:.|.:
Worm    65 PKLLFQVESQSQSNSCRWSPDGKRFAFGSDDSSVSVW------EYVGLINSMGSITGGAQNVERY 123

  Fly   124 LTLKVLRGHREDIYDLSWAPNSQFLVSGSVDNTAMLWDVHS-GKSLAILDDHKGYVQGVAWDPCN 187
            ....|||||..::..:.|:||.::|.|||:|...::::... ...:.:|:|.:..|:|::|||..
Worm   124 KECCVLRGHSMEVLTVEWSPNGKYLASGSIDYRIIIYNARKLPDRITVLNDIQLPVKGLSWDPIG 188

  Fly   188 QYIATMSTDRQMRIFDANTKRVLHRVSKCVLPVKEDHEMHGKSMRLYQDGTLQTFFRRLCFTPDG 252
            :|:|::..|:::|.:..::       .:||..|.|.          ::....:|...||.::|||
Worm   189 KYLASLEGDKKLRFWATDS-------WQCVKSVTEP----------FESNIEETMLTRLDWSPDG 236

  Fly   253 KLLLTPSGITDYDGVVKPINTSYGFSRHDLSKPAFVLPFPKEYAVAVRCSPVLYRLRPYNAEKNP 317
            |.|:||:.:.....::|.|      .|.......|:....|. ...||..|.|......|.::..
Worm   237 KYLMTPAAVRSGKPLIKLI------QRQTWKSDQFLAGHHKG-TTCVRAMPRLIEANLKNGKRMQ 294

  Fly   318 PIISLPYRMIYAVATKNAVF----FYDTQQPVPFAIVSNIHYSRLTDLAWSSDGTVLIVSSTDGY 378
            ...:       ||.:::...    |..|.:|:  .:::||....:.|.||.  |..|:..|.||.
Worm   295 LTCA-------AVGSRDKSISIWVFPGTLKPL--FVINNIFNHTVMDFAWC--GRNLLACSQDGT 348

  Fly   379 CSLITFEPTELGD----------CYE------------DMET-------VLSVVLKSSENAT--- 411
            ..:|....:.:|:          ||:            |.|.       .||.:..|:.||:
Worm   349 VKVIHLSESVIGEMISNEAMSDLCYQIYSIRPPRYELTDKEEDESQDSFNLSDLSSSANNASFVT 413

  Fly   412 -----VLKKKRQKLRKVSLD-EPRKPLQEKSKPNTIRRASEAGITEVGEPELDAENDSSTH---S 467
                 ::|:|:....:.|.| :..|.:::.||.|..:. ||..:.|....::|...|....   .
Worm   414 CPEDVLIKRKKLVAAQQSSDIQLTKSMEDNSKENESKN-SEKTMMEERNKQIDVRKDGKRRIQPV 477

  Fly   468 VSSNKTNSPKTKASEEEKPTPIAIRRSPRKNSTAPMPIAIRR--APRKPEDKG-----NSESSKP 525
            .....|..|.|..|.|.|.|            .||.| |.|:  ||..|..||     :|..|..
Worm   478 FCGTTTADPMTSLSSEGKKT------------VAPPP-AKRKALAPAVPAKKGEVDLEDSSDSDD 529

  Fly   526 KDEMEVTHTKTTQVQKTVASPVKRKVSTEAVPPAETSQPALAVIPVFEKEIISSDDKFESPEKKS 590
            .||.|....:.:.::.  ....||||      ||.||||.||:                  :.|.
Worm   530 DDEEEEEDMEISDIES--VRNKKRKV------PATTSQPMLAL------------------DLKK 568

  Fly   591 RPATPIQVRRQPRTPGSSSQFNLTPKSQPAKQATPIAVRRTPRVLIEMPVNSPVVPMEEAMDAWP 655
            ....|::                 |||...::.|         ||:|.|...|.: .:..:|...
Worm   569 PALRPME-----------------PKSLKTQEGT---------VLMEAPEQQPKL-SQHVVDRKG 606

  Fly   656 LDESITPLPATKKDSRKPLPETVKTETKPAVIEASEATCERTEDI 700
            :...|        |:|........|:.|  :|:..:.|.|..:|:
Worm   607 MFVEI--------DNRWKHGGVETTQIK--LIKKKQQTAENEDDM 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Caf1-105	NP_610589.2	WD40	13..377	CDD:295369	91/380 (24%)
		WD40	67..446	CDD:225201	100/432 (23%)
		WD40 repeat	75..131	CDD:293791	19/58 (33%)
		WD40 repeat	136..172	CDD:293791	8/36 (22%)
		WD40 repeat	179..213	CDD:293791	8/33 (24%)
		WD40 repeat	243..290	CDD:293791	13/46 (28%)
		WD40 repeat	358..382	CDD:293791	8/23 (35%)
hira-1	NP_498101.2	WD40	<10..359	CDD:225201	95/398 (24%)
		WD40	10..351	CDD:295369	94/390 (24%)
		WD40 repeat	19..71	CDD:293791	12/60 (20%)
		WD40 repeat	79..131	CDD:293791	18/57 (32%)
		WD40 repeat	137..174	CDD:293791	9/36 (25%)
		WD40 repeat	179..219	CDD:293791	13/56 (23%)
		WD40 repeat	227..267	CDD:293791	13/45 (29%)
		WD40 repeat	274..321	CDD:293791	10/55 (18%)
		Hira	688..877	CDD:284895
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D366817at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920