DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Caf1-105 and chaf-2

DIOPT Version :9

Sequence 1:	NP_610589.2	Gene:	Caf1-105 / 36107	FlyBaseID:	FBgn0033526	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_490901.2	Gene:	chaf-2 / 171747	WormBaseID:	WBGene00022141	Length:	489	Species:	Caenorhabditis elegans

Alignment Length:	526	Identity:	165/526 - (31%)
Similarity:	250/526 - (47%)	Gaps:	86/526 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IPEISWHNRDPVLSVDIQ---QNGLGLRSPTICRLASGG--SDAHVLIWYV--------NRSDDA 56
            :|.|.||:|..:||||:.   :||.       .|||:..  .:..|.:|..        ...::.
Worm     5 MPIIYWHDRKGLLSVDLHHETRNGK-------YRLATASVQKEVRVRVWEFEFEMGLDPKTQENK 62

  Fly    57 EGVDVELAADLSRHQRAVNAVRWSPN--GELLASGDDESVVFIWKQKADHEVVNIVDADGCSEQD 119
            ..:.|...|:|..|..|:|.|::||:  .|||||||.|..:.||| .:|..|....|.   ...:
Worm    63 PQLTVGFLANLVFHNHAINQVKFSPSKEHELLASGDCEGRITIWK-LSDQPVPPPQDE---MPSN 123

  Fly   120 KEVWLTLKVLRGHREDIYDLSWAPNSQFLVSGSVDNTAMLWDVHSGKSLAILDDHKGYVQGVAWD 184
            ||.|:..||| .|..|:..|.|.|:...|.|.|.|:|..:.|..:||.|.:..:.:. ..||.||
Worm   124 KENWIRYKVL-NHNSDVNALCWDPSGTQLASVSNDHTLAVHDALTGKRLFVASNFRS-PNGVCWD 186

  Fly   185 PCNQYIATMSTDRQMRIFDANTKRVLHRVSKCVLP------VKEDHEMHGKSMRLYQDGTLQTFF 243
            |..:||||||.||:|.:.||.....|...|..:||      ...|..:..|..:|:.|..|.:|.
Worm   187 PSGKYIATMSPDRKMDLIDAVRGARLKHFSSALLPSMTIPSANGDLHLETKIHKLFHDDQLFSFQ 251

  Fly   244 RRLCFTPDGKLLLTPS-----GITDYDGVVKPINTSYGFSRHDL---SKPAFVLPFPKEYAVAVR 300
            |.|.|:|:|:.:..|.     |.:|..|       :|.|.|.||   ..|....|.|:. ...|:
Worm   252 RALGFSPNGEFIAAPCAHLELGSSDLYG-------TYFFRREDLGVKEAPYTFYPAPRP-TFLVK 308

  Fly   301 CSPVLYRLRPYNAEKNPPIISLPYRMIYAVATKNAVFFYDTQQPVPFAIVSNIHYSRLTDLAWSS 365
            .|||.:.|.|...|.:   :.||||:::....|:|::|||:|...|.|:|.|||.:.|||.::|.
Worm   309 FSPVTFSLLPSTKENH---LGLPYRLLWIALNKDAIYFYDSQHSYPVAVVDNIHLNALTDASFSH 370

  Fly   366 DGTVLIVSSTDGYCSLITFEPTELGDCYEDMETVLSVVLKSSENATVLKKKRQKLRKVSLD---E 427
            ||.||:|||.:|:||.:....|:.|:       |::.::....:..::::|:||.||.::.   |
Worm   371 DGRVLVVSSLEGFCSFVKINLTQWGE-------VMTEIVPVCGSPNLIEEKKQKKRKSTVAVVIE 428

  Fly   428 PRKPLQEKSKPNTIRRASEAGITEVGEPELDAENDSSTHSVSSNK-TNSPKT----KASEEEKPT 487
            ..|..:|.:..:.:|:.||                  |..||:.| ..:|.|    |.:..|.||
Worm   429 KEKEKEEDAAKSPMRKPSE------------------TPKVSTPKAAGTPLTKFFKKENNTESPT 475

  Fly   488 PIAIRR 493
            |...:|
Worm   476 PPVKKR 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Caf1-105	NP_610589.2	WD40	13..377	CDD:295369	132/392 (34%)
		WD40	67..446	CDD:225201	133/397 (34%)
		WD40 repeat	75..131	CDD:293791	24/57 (42%)
		WD40 repeat	136..172	CDD:293791	12/35 (34%)
		WD40 repeat	179..213	CDD:293791	17/33 (52%)
		WD40 repeat	243..290	CDD:293791	15/54 (28%)
		WD40 repeat	358..382	CDD:293791	14/23 (61%)
chaf-2	NP_490901.2	WD40	<14..216	CDD:392136	71/214 (33%)
		WD40 repeat	81..134	CDD:293791	24/57 (42%)
		WD40 repeat	139..178	CDD:293791	12/38 (32%)
		WD40 repeat	181..216	CDD:293791	17/34 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167200
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	201	1.000	Inparanoid score	I2467
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D366817at33208
OrthoFinder	1	1.000	-	-		FOG0004789
OrthoInspector	1	1.000	-	-		oto17893
orthoMCL	1	0.900	-	-		OOG6_102357
Panther	1	1.100	-	-	LDO	PTHR15271
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1796
SonicParanoid	1	1.000	-	-		X3374
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.930