DRSC/TRiP Functional Genomics Resources

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Protein Alignment Caf1-105 and Hira

DIOPT Version :10

Sequence 1:NP_610589.2 Gene:Caf1-105 / 36107 FlyBaseID:FBgn0033526 Length:747 Species:Drosophila melanogaster
Sequence 2:NP_034565.2 Gene:Hira / 15260 MGIID:99430 Length:1015 Species:Mus musculus


Alignment Length:762 Identity:172/762 - (22%)
Similarity:311/762 - (40%) Gaps:163/762 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 KIPEISW--HNRDPVLSVDIQQNGLGLRSPTICRLASGG---SDAHVLIWYVN---RSDDAEGVD 60
            |:.:.:|  ||..|:.||||..:|        .:.|:||   ....|:||.::   :.||.:..:
Mouse     2 KLLKPTWVNHNGKPIFSVDIHPDG--------TKFATGGQGQDSGKVVIWNMSPVLQEDDEKDEN 58

  Fly    61 V-ELAADLSRHQRAVNAVRWSPNGELLASGDDESVVFIWKQKADHEVVNIVDADGCSEQDKEVWL 124
            : ::...:..|...||.||||.:|..||||.|:.::.:|| :|.:...:.|........:.|.|.
Mouse    59 IPKMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWK-RATYIGPSTVFGSSGKLANVEQWR 122

  Fly   125 TLKVLRGHREDIYDLSWAPNSQFLVSGSVDNTAMLWD-VHSGKSLAILDDHKGYVQGVAWDPCNQ 188
            .:.:||.|..|:.|::|:|:..:|.|.|||||.::|: |...:.||.|..|.|.|:|:.|||..:
Mouse   123 CVSILRSHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGK 187

  Fly   189 YIATMSTDRQMRIFDANTKRVLHRVSKCVLPVKEDHEMHGKSMRLYQDGTLQTFFRRLCFTPDGK 253
            |||:.:.||.::::     |.|            |.::.....:.:.:....|...||.::|||.
Mouse   188 YIASQADDRSLKVW-----RTL------------DWQLETSITKPFDECGGTTHVLRLSWSPDGH 235

  Fly   254 LLLTPSGITDYDGVVKPI-----NTSYGFSRHDLSKPAFVLPFPKEYAVAVRCSPVLYRLRPYNA 313
            .|::...:.:.....:.|     .|:..|..|            ::....|:.:|.:::.:..|.
Mouse   236 YLVSAHAMNNSGPTAQIIEREGWKTNMDFVGH------------RKAVTVVKFNPKIFKKKQKNG 288

  Fly   314 EKNPPIISLPYRMIYAVATKN-AVFFYDTQQPVPFAIVSNIHYSRLTDLAWSSDGTVLIVSSTDG 377
            ....|  |.|| ...||.:|: ::..:.|....|..::..:....:.|::|:.:|..::|.|.||
Mouse   289 SSTKP--SCPY-CCCAVGSKDRSLSVWLTCLKRPLVVIHELFDKSIMDISWTLNGLGILVCSMDG 350

  Fly   378 YCSLITFEPTELGDCYEDME----------TVLSVVLKSS------ENATVLKKKRQKLRKVSLD 426
            ..:.:.|...||||...:.|          ..|:::.::.      ||..:||.:|:: ::..||
Mouse   351 SVAFLDFSQDELGDPLSEEEKSRIHQSTYGKSLAIMTEAQLSTAVIENPEMLKYQRRQ-QQQQLD 414

  Fly   427 EPRKPLQEKSKPNTIRRASEAGITEVGEPELDAENDSSTHSVSSN--KTNSPKTKASEEEKPTPI 489
            :.....:|.|..:::     .|:.          |..|...:..|  |.......|....:.||:
Mouse   415 QKNATTRETSSASSV-----TGVV----------NGESLEDIRKNLLKKQVETRTADGRRRITPL 464

  Fly   490 AIRRSPRKN-STA---PMPIAIRRAPRK----------PEDKGNSE--SSKPKDEMEVTHTKTTQ 538
            .|.:....: |||   .:|::...|...          |.|.....  :|||         .|..
Mouse   465 CIAQLDTGDFSTAFFNSIPLSSSLAGTMLSSPSGQQLLPLDSSTPSFGASKP---------CTEP 520

  Fly   539 VQKTVASPVKRKVSTEAVPPAET---SQPALAVIPVFEKEIISSDDKFESPEKKSRPATPIQVRR 600
            |..|.|.|....||.:::....|   |.|::...|...:.:.:.|.:|              ..|
Mouse   521 VAATSARPTGESVSKDSMNATSTPAASSPSVLTTPSKIEPMKAFDSRF--------------TER 571

  Fly   601 QPRTPGSSSQFNLTPKS-QPAKQATPIAVRRT-----------------PRVLIEMPVNSPVVPM 647
            ...|||:.|..::.|.: :..|:...:...|:                 |..|.:..:...|..:
Mouse   572 SKATPGAPSLTSVIPTAVERLKEQNLVKELRSRELESSSDSDEKVHLAKPSSLSKRKLELEVETV 636

  Fly   648 EEAMDAWPLDESITPLPATKKDSRKPLPETVKTETKPAVIEASEATC 694
            |:.....|           :||||. ||.::..::..|:....||.|
Mouse   637 EKKKKGRP-----------RKDSRL-LPMSLSVQSPAALSTEKEAMC 671

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Caf1-105NP_610589.2 WD40 <4..377 CDD:441893 99/388 (26%)
WD40 repeat 75..131 CDD:293791 18/55 (33%)
WD40 repeat 136..172 CDD:293791 14/36 (39%)
WD40 repeat 179..213 CDD:293791 11/33 (33%)
WD40 repeat 243..290 CDD:293791 10/51 (20%)
WD40 repeat 358..382 CDD:293791 7/23 (30%)
PHA03247 <472..742 CDD:223021 51/260 (20%)
HiraNP_034565.2 WD40 <3..352 CDD:441893 100/389 (26%)
WD 1 11..53 14/49 (29%)
WD40 repeat 16..61 CDD:293791 13/52 (25%)
WD 2 68..107 16/39 (41%)
WD40 repeat 74..129 CDD:293791 18/55 (33%)
WD 3 129..168 14/38 (37%)
WD40 repeat 134..171 CDD:293791 14/36 (39%)
WD 4 172..211 15/55 (27%)
WD40 repeat 178..213 CDD:293791 12/51 (24%)
WD 5 220..263 9/42 (21%)
WD40 repeat 226..265 CDD:293791 8/38 (21%)
WD 6 266..322 13/70 (19%)
WD40 repeat 273..324 CDD:293791 12/53 (23%)
WD 7 326..367 12/40 (30%)
WD40 repeat 331..354 CDD:293791 7/22 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 408..431 4/28 (14%)
Interaction with CCNA1. /evidence=ECO:0000250 421..727 57/301 (19%)
Interaction with ASF1A. /evidence=ECO:0000250 421..479 14/72 (19%)
Required for repression of histone gene transcription. /evidence=ECO:0000250 439..475 6/35 (17%)
Treacle <483..>712 CDD:460967 43/224 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 494..558 16/72 (22%)
Interaction with PAX3. /evidence=ECO:0000269|PubMed:9731536 593..737 17/91 (19%)
Interaction with histone H2B. /evidence=ECO:0000250 594..824 16/90 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 603..623 1/19 (5%)
Interaction with histone H4. /evidence=ECO:0000250 736..1015
Interaction with PAX3. /evidence=ECO:0000269|PubMed:9731536 738..826
Hira 778..960 CDD:462211
Blue background indicates that the domain is not in the aligned region.

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