DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Caf1-105 and chaf1b

DIOPT Version :9

Sequence 1:	NP_610589.2	Gene:	Caf1-105 / 36107	FlyBaseID:	FBgn0033526	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	XP_012813446.1	Gene:	chaf1b / 100127620	XenbaseID:	XB-GENE-996578	Length:	569	Species:	Xenopus tropicalis

Alignment Length:	635	Identity:	249/635 - (39%)
Similarity:	337/635 - (53%)	Gaps:	101/635 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKCKIPEISWHNRDPVLSVDIQQNGLGLRSPTICRLASGGSDAHVLIWYVNRSDDAEGVDVELAA 65
            ||....||:|||::||.|:|.|..     :..|.|:||.|.|..|.:|.:.:|.:.:.: ||..|
Frog     1 MKVITCEIAWHNKEPVYSLDFQHG-----TDRINRMASAGVDTAVRMWKIEKSPEGKAI-VEFVA 59

  Fly    66 DLSRHQRAVNAVRWSPNGELLASGDDESVVFIWKQKADHEVVNIVDADGCSEQD-----KEVWLT 125
            .|:||.:|||.||:|||||:||||.|::.:.:||.....|    .:|....|||     ||.|..
Frog    60 SLARHTKAVNVVRFSPNGEILASGGDDAAIVLWKLNEAKE----PEATPFQEQDEPELNKENWTV 120

  Fly   126 LKVLRGHREDIYDLSWAPNSQFLVSGSVDNTAMLWDVHSGKSLAILDDHKGYVQGVAWDPCNQYI 190
            ||.||||.||:||:.|..:|.|:||.||||||::|||..|:.|:|.::||.|||||.|||..|||
Frog   121 LKTLRGHLEDVYDICWTQDSNFMVSASVDNTAIMWDVTKGQKLSIFNEHKSYVQGVTWDPLGQYI 185

  Fly   191 ATMSTDRQMRIFDANTKRVLHRVSKCVLPVKEDHEMHGKSMRLYQDGTLQTFFRRLCFTPDGKLL 255
            ||:|.||.||::...||||.:.|||.......|.|:  ||.|:|.|.::::|||||.|||||.||
Frog   186 ATLSCDRIMRVYKTETKRVAYNVSKMASAPGADGEV--KSFRMYHDDSMKSFFRRLTFTPDGSLL 248

  Fly   256 LTPSGITDYDGVVKPINTSYGFSRHDLSKPAFVLPFPKEYAVAVRCSPVLYRLRPY----NAEKN 316
            :||:|..:....|  |||:|.|||.:|.:|...||.|.:..:||||.|:.:.|||.    :.|..
Frog   249 ITPAGCVESGESV--INTTYVFSRKNLKRPMAHLPCPTKATLAVRCCPIYFELRPTVKDDSGESQ 311

  Fly   317 PP-IISLPYRMIYAVATKNAVFFYDTQQPVPFAIVSNIHYSRLTDLAWSSDGTVLIVSSTDGYCS 380
            |. :|:.||||::|||:::||.||||||..||..|||:||..|:|::|||||..|.:||||||||
Frog   312 PQGLITQPYRMVFAVASEDAVLFYDTQQLFPFGYVSNVHYHTLSDISWSSDGRFLAISSTDGYCS 376

  Fly   381 LITFEPTELGDCYEDMETVLSVVLKSSENATVLKKKRQKLRKVSLDEPRKPLQEKSKPNTIRRAS 445
            .:|||..|||                                |.|.|...||..|: |.|.|:..
Frog   377 FVTFEEGELG--------------------------------VPLKEKPVPLIPKT-PATERKIK 408

  Fly   446 EAGITEVGEP----ELDAENDSSTHSVSSNKTNSPKTKASEEEKPTPIAIRRSPRKNSTAPMPIA 506
            :|...:|..|    ||...|.|..||..|...||....||...:.||:    |....|:.|
Frog   409 KAQSKKVSSPGSRQELTPSNKSMEHSTPSTPMNSRAAAASGSRECTPV----SSHSLSSTP---- 465

  Fly   507 IRRAPRKPEDKGNSESSKPKDEMEVTHTKTTQVQKTVASPVKRKVSTEAV----PPAETSQPALA 567
                  ..||| .|:..:|:..|    ..|.:......:|..|::|..:|    |.:..|.||.:
Frog   466 ------NSEDK-KSKGGQPRRIM----LNTLEAWSKPTTPSPRRISLISVKTNSPGSAQSSPAPS 519

  Fly   568 VIP---VFEKEIISSDDK-FESPEKK-------------SRPATPIQVRR 600
            ..|   .....:..|:|. .:|||.|             .:|:|..|..:
Frog   520 TAPRPQTSPSAVSPSEDAGCKSPESKRLRTEDSPSCSSADKPSTTDQTNK 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Caf1-105	NP_610589.2	WD40	13..377	CDD:295369	178/373 (48%)
		WD40	67..446	CDD:225201	181/388 (47%)
		WD40 repeat	75..131	CDD:293791	26/60 (43%)
		WD40 repeat	136..172	CDD:293791	19/35 (54%)
		WD40 repeat	179..213	CDD:293791	20/33 (61%)
		WD40 repeat	243..290	CDD:293791	24/46 (52%)
		WD40 repeat	358..382	CDD:293791	16/23 (70%)
chaf1b	XP_012813446.1	WD40	11..294	CDD:392136	140/296 (47%)
		WD40 repeat	16..63	CDD:293791	17/52 (33%)
		WD40 repeat	69..126	CDD:293791	26/60 (43%)
		WD40 repeat	131..167	CDD:293791	19/35 (54%)
		WD40 repeat	174..229	CDD:293791	29/56 (52%)
		CAF-1_p60_C	386..553	CDD:373912	51/218 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	44	1.000	Domainoid score	I12171
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48346
Inparanoid	1	1.050	391	1.000	Inparanoid score	I1951
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D366817at33208
OrthoFinder	1	1.000	-	-		FOG0004789
OrthoInspector	1	1.000	-	-		oto103296
Panther	1	1.100	-	-	LDO	PTHR15271
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1796
SonicParanoid	1	1.000	-	-		X3374
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.100