Protein Alignment Cyp49a1 and DIT2

DIOPT Version :10

• Sequence 1: NP_610588.2
• Gene: Cyp49a1 / 36105
• FlyBaseID: FBgn0033524
• Length: 589
• Species: Drosophila melanogaster
• Sequence 2: NP_010690.1
• Gene: DIT2 / 852011
• SGDID: S000002810
• Length: 489
• Species: Saccharomyces cerevisiae
• Alignment Length: 540
• Identity: 116/540 - (21%)
• Similarity: 204/540 - (37%)
• Gaps: 141/540 - (26%)

  Fly   106 PYPLPLIGNSWRFAPLIGTYKISDL-DKVMNELHVNYGKMAKVGGLIGHPDLLFVFDGDEIRNIF 169
            |..:|.|.....|.|:|.....::| |..:.|....||   .|....|....:.|...:.:..||
Yeast    30 PKNIPTIPFYVVFLPVIFPIDQTELYDLYIRESMEKYG---AVKFFFGSRWNILVSRSEYLAQIF 91

  Fly   170 KKEEAMP---HRPSMP--SLRHYKGDLRRDFFGDVAGLIGVHGPKWEAFRQEV----QHI----- 220
            |.|:...   ::..:|  :|..|.||          .:|..:|..|..:|..|    ||.
Yeast    92 KDEDTFAKSGNQKKIPYSALAAYTGD----------NVISAYGAVWRNYRNAVTNGLQHFDDAPI 146

  Fly   221 --------------LLQPQTAKKYIPPLNDIASEFMGRIELMRDEKDELPANFLHELYKWALESV 271
                          ||:.||:   ||         ||.:.                 .:.||:::
Yeast   147 FKNAKILCTLIKNRLLEGQTS---IP---------MGPLS-----------------QRMALDNI 182

  Fly   272 GRVSLDTRLGCLSPEGSEEAQQII----EAINTFFWAVPELELRMPLWRIYPT--KAYRSFVKAL 330
            .:|:|....|.|:.|.:...:.:|    :..:.||...|.|:: :|:    |:  ||::..|
Yeast   183 SQVALGFDFGALTHEKNAFHEHLIRIKKQIFHPFFLTFPFLDV-LPI----PSRKKAFKDVV--- 239

  Fly   331 DQFTAICMKNIGKTMDKADADEARGLSKSEADISIVERIVRKTGN-----RKLAAILALDLFLVG 390
             .|..:.:|.:        .||.....|.|........::|...|     ::|...:.: :.:.|
Yeast   240 -SFRELLVKRV--------QDELVNNYKFEQTTFAASDLIRAHNNEIIDYKQLTDNIVI-ILVAG 294

  Fly   391 VDTTSVAASSTIYQLAKNPDK-QKKLFDELQKVFPHREADINQNVLEQMPYLRACVKETLRMRPV 454
            .:...:..:|::|.|||..:: |:||..|:..:       .:...|..:|.|.|.:.|.:||.|.
Yeast   295 HENPQLLFNSSLYLLAKYSNEWQEKLRKEVNGI-------TDPKGLADLPLLNAFLFEVVRMYPP 352

  Fly   455 V--IANGRSLQSDAVINGYHVPKGTHVIFPHLVVSNDP-AYFPEPKRFLPERW------------ 504
            :  |.|..:.::..:.....:|||.:|.:.:...|:|| .:......|.||||
Yeast   353 LSTIINRCTTKTCKLGAEIVIPKGVYVGYNNFGTSHDPKTWGTTADDFKPERWGSDIETIRKNWR 417

  Fly   505 -LKQSTDAAGCPHANQKIHPFVSLPFGFGRRMCVGRRFAEIELHTLLAKIFRKYKVSYNSGEFVY 568
             .|......|               |..|||.|:|.:.|..|:...||::.::::.|.:. |:..
Yeast   418 MAKNRCAVTG---------------FHGGRRACLGEKLALTEMRISLAEMLKQFRWSLDP-EWEE 466

  Fly   569 RVNSTYIPQSPLNFKLTLRD 588
            ::.... |..|||.||...:
Yeast   467 KLTPAG-PLCPLNLKLKFNE 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp49a1	NP_610588.2	CYP24A1-like	138..581	CDD:410677	103/498 (21%)
DIT2	NP_010690.1	CYP56-like	65..485	CDD:410693	107/503 (21%)