DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp49a1 and cyp27b1

DIOPT Version :9

Sequence 1:	NP_001246256.1	Gene:	Cyp49a1 / 36105	FlyBaseID:	FBgn0033524	Length:	589	Species:	Drosophila melanogaster
Sequence 2:	NP_001298720.1	Gene:	cyp27b1 / 793309	ZFINID:	ZDB-GENE-111005-2	Length:	505	Species:	Danio rerio

Alignment Length:	537	Identity:	149/537 - (27%)
Similarity:	249/537 - (46%)	Gaps:	72/537 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 TTASSLP----AE-----TTSSPAAAVRPYSEVPGPYPLPLIGNSWRFAPLIGTYKISDLDKVMN 135
            |..|:||    ||     ..:.|...|:...::|||.|...|.:      |......|.|.::..
Zfish    12 TGRSALPLLRFAERWADVIRAPPTPQVKTLEQMPGPSPARFIRD------LFMKRGFSRLHQLQL 70

  Fly   136 ELHVNYGKM--AKVGGL----IGHPDLLFVFDGDEIRNIFKKEEAMPHRPSMPSLRHYKGDLRRD 194
            |....||.|  |..|.:    :..|:|        |:.:.::|...|.|..:.|.:.|:. ||
Zfish    71 EGRQKYGPMWKASFGPILTVHVAEPEL--------IQQVLRQEGQHPVRSELSSWKDYRA-LR-- 124

  Fly   195 FFGDVAGLIGVHGPKWEAFRQEVQHILLQPQTAKKYIPPLNDIASEFMGRIELMRDE-KDELPAN 258
              |:..||:...|.:|:..|..:...:|:||..:.|...||.:.|:.:.:::|...| ...:.::
Zfish   125 --GEGYGLLTAEGEEWQCVRSLLSKHMLRPQAVEAYDGALNAVVSDLLQKLKLRSQESSSRIVSD 187

  Fly   259 FLHELYKWALESVGRVSLDTRLGCLSPEGSEEAQQIIEAINTFFWAVPELELRMPLW--RIYPTK 321
            ...|.|::.||.:..|..::|:|||......|.::.|::|||.| .:..|.:.||.|  |:.| |
Zfish   188 ISAEFYRFGLEGISSVLFESRIGCLDAVVPVETERFIQSINTMF-VMTLLTMAMPQWLHRLLP-K 250

  Fly   322 AYRSFVKALDQFTAICMKNIGKTMDK-------ADADEARGLS--KSEADISIVERIVRKTGNRK 377
            .:.:|.:..|........:|.:.:.:       .:..|.|.|:  .|:|.:.:.......|
Zfish   251 PWDTFCRCWDVMFEFAKGHIDQRLQEEKQKLECGEQLEGRYLTYFLSQAGLPLTSVYSNVT---- 311

  Fly   378 LAAILALDLFLVGVDTTSVAASSTIYQLAKNPDKQKKLFDELQKVFPHREADINQNVLEQMPYLR 442
                   :|.|.||||.|...|.::|:|:::||.|..|.||:..|...|......:| ..||.|:
Zfish   312 -------ELLLAGVDTISSTLSWSLYELSRHPDVQTALRDEVLSVMKDRSVPQASDV-AAMPLLK 368

  Fly   443 ACVKETLRMRPVVIANGRSLQSDAVINGYHVPKGTHVIFPHLVVSNDPAYFPEPKRFLPERWLKQ 507
            |.|||.||:.||:.||.|.:..|..:.||.:||.|.:...|...|.||..|.:|..|.|:||..:
Zfish   369 AVVKEILRLYPVIPANARVINKDIEVGGYVIPKNTLITLCHYATSRDPQQFRDPDSFRPQRWGDR 433

  Fly   508 STDAAGCPHANQKIHPFVSLPFGFGRRMCVGRRFAEIELHTLLAKIFRKYKVS-YNSGEFVYRVN 571
            |          .:.||:.::|||.|:|.|:|||.||:|::..|::|...:.:. ....:.|:.:.
Zfish   434 S----------DRSHPYATVPFGVGKRSCIGRRIAELEVYLALSRILMHFTMEPVRENDTVHPMT 488

  Fly   572 ST-YIPQSPLNFKLTLR 587
            .| .:|:..::.:.|.|
Zfish   489 RTLLVPERQIDLRFTER 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp49a1	NP_001246256.1	p450	104..565	CDD:299894	136/479 (28%)
cyp27b1	NP_001298720.1	p450	45..493	CDD:278495	138/490 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2609
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3547
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.970