DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp49a1 and cyp11c1

DIOPT Version :9

Sequence 1:	NP_001246256.1	Gene:	Cyp49a1 / 36105	FlyBaseID:	FBgn0033524	Length:	589	Species:	Drosophila melanogaster
Sequence 2:	XP_017206857.1	Gene:	cyp11c1 / 791124	ZFINID:	ZDB-GENE-070828-1	Length:	701	Species:	Danio rerio

Alignment Length:	548	Identity:	142/548 - (25%)
Similarity:	227/548 - (41%)	Gaps:	106/548 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 RTTASSLPAETTSSPAAAVRPYSEVPGPYPLPLIGNS--------WRFAPLIGTYKISDLDKVMN 135
            |.:....|...:|..|.|.|.:.|:|.      .|::        ||..      :.|.:.|.|.
Zfish   201 RASVCVRPLHQSSRSAGAARLFQEIPD------TGSNGWMNLLRFWRDG------RFSRMHKHME 253

  Fly   136 ELHVNYGKMAKVG-GLIGHPDLLFVFDGDEIRNIFKKEEAMPHRPSM-------PSLRHYKGDLR 192
            |.....|.:.:.. |.....:::...|..|   :|:.|...|.|.::       .:.||.||...
Zfish   254 ESFRRLGPIYREHLGSQSSVNIMLPMDTGE---LFRSEGLHPRRMTLQPWATHRETRRHSKGVFL 315

  Fly   193 RDFFGDVAGLIGVHGPKWEAFRQEVQHILLQPQTAKKYIPPLNDIASEF----MGRIELMRDEK- 252
            :            :|.:|.|.|..:...::...:..:::|.|:::|.:|    ..|::....||
Zfish   316 K------------NGTEWRADRLLLNREVMVSSSVHRFLPLLDEVAQDFCRSLRRRVQADGFEKA 368

  Fly   253 -------DELPANFLHELYKWALESVGRVSLDTRLGCLSPEGSEEAQQIIEAINTFFWAVPE--- 307
                   |..|     :|:::|||:...|....|:|..|...|:|:::.|.|:.......|.
Zfish   369 GQHTLTLDPSP-----DLFRFALEASCHVLYGERIGLFSSCPSDESERFISAVERMLATTPPLLY 428

  Fly   308 ------LELRMPLWRIYPTKAYRSFVKALDQFTAICMKNIGKTMDKADADEARGLSKSEADISIV 366
                  |.||..||..:.|        |.|...:...:.|.::..:.   :||..:..:.....|
Zfish   429 LPPRLLLRLRASLWTTHAT--------AWDDIFSHAEQRIQRSYQRL---QARPSAAPDCSFPGV 482

  Fly   367 ERIVRKTGNRKLAAILA--LDLFLVGVDTTSVAASSTIYQLAKNPDKQKKLFDELQKVFPHREAD 429
            ...:.:.|...|..|.|  .:|...|||||:|.....:::||:|||.|:.:..::...:.....|
Zfish   483 LGKLMEAGQLSLELIRANITELMAGGVDTTAVPLQFALFELARNPDVQECVRAQVLSSWQQASGD 547

  Fly   430 INQNVLEQMPYLRACVKETLRMRPVVIANGRSLQSDAVINGYHVPKGTHV---IFPHLVVSNDPA 491
             ....|:..|.|:..:|||||:.||.|...|....|.|:..||||.||.|   ::|   :.....
Zfish   548 -PLKALQGAPLLKGTIKETLRLYPVGITVQRYPVRDIVLQNYHVPAGTLVQVCLYP---LGRSAE 608

  Fly   492 YFPEPKRFLPERWLKQSTDA-AGCPHANQKIHPFVSLPFGFGRRMCVGRRFAEIELHTLLAKIFR 555
            .|..|:.|.|.||   |.|| ||....      |.||.||||.|.|||||.||.|:..||..|.|
Zfish   609 VFSRPECFDPSRW---SADADAGSAGG------FRSLAFGFGSRQCVGRRIAENEMQLLLMHILR 664

  Fly   556 KYKVSYNSGEFVYRVNSTYI----PQSP 579
            .:|::.:|.|   .:::.|.    |:.|
Zfish   665 TFKLTVSSTE---ELSTKYTLILQPECP 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp49a1	NP_001246256.1	p450	104..565	CDD:299894	131/503 (26%)
cyp11c1	XP_017206857.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820