Protein Alignment Cyp49a1 and cyp27a1.3

DIOPT Version :9

• Sequence 1: NP_001246256.1
• Gene: Cyp49a1 / 36105
• FlyBaseID: FBgn0033524
• Length: 589
• Species: Drosophila melanogaster
• Sequence 2: XP_002934001.3
• Gene: cyp27a1.3 / 594905
• XenbaseID: XB-GENE-18386061
• Length: 518
• Species: Xenopus tropicalis
• Alignment Length: 568
• Identity: 173/568 - (30%)
• Similarity: 259/568 - (45%)
• Gaps: 90/568 - (15%)

  Fly    52 QRLRTGESSNPKKLNVSQQPVTSVATTRTTASSLPAETTSSPAAAVRPYSEVPGPYPLPLIGNSW 116
            ||||||..:     .:.|....:|.|.|..|:...:..|......::...::|||.||.|:  .|
 Frog     4 QRLRTGAQA-----LLQQSCRANVQTVRKKATLGVSGATVVEGKTLKTLDDLPGPSPLKLL--YW 61

  Fly   117 RFAPLIG-TYKISDLDKVMNELHVNYGKMAKVGG------LIGHPDLLFVFDGDEIRNIFKKEEA 174
            .|  |.| .::..:|..:..:   .||.|.|:..      .:..||||        .::.:||..
 Frog    62 IF--LRGYLFRTHELQVIFKK---TYGPMWKMSDRQHAMVTVASPDLL--------ESLLRKEGK 113

  Fly   175 MPHRPSMPSLRHYKGDLRRDFFGDVAGLIGVHGPKWEAFRQEVQHILLQPQTAKKYIPPLNDIAS 239
            .|.|..|..:|.:: |||...:|.|.    ..|.:|...|..:...:|:|:....|...:|::.|
 Frog   114 YPTRADMFIMREHR-DLRGHSYGPVT----EEGHQWHRIRTILNQRMLKPRETVVYAGSMNEVVS 173

  Fly   240 EFMGRI-ELMRDEKDELPANFLHEL-YKWALESVGRVSLDTRLGCLSPEGSEEAQQIIEAINTFF 302
            :.:.:| ||..........|.:.|| ||:|.||:..|..:||||||:.|...|.|:.|::|....
 Frog   174 DLLLKIKELTAQSSSGTQVNGVAELMYKFAFESICTVLFETRLGCLNKEILPETQKFIDSIGIML 238

  Fly   303 WAVPELELRMPLWRIYPTKA----YRSFVKALDQFTAICMKNIGKTMDKADADEARG-------- 355
            ..:..| .|:|.|    ||.    :..:::|.|.......|.|.|.|:..:....||
 Frog   239 EHLTML-TRLPQW----TKGILPYWGRYIEAWDTIFDFGKKLIDKKMEDIEGRLKRGEEVEGEYL 298

  Fly   356 --------LSKSEADISIVERIVRKTGNRKLAAILALDLFLVGVDTTSVAASSTIYQLAKNPDKQ 412
                    ||..|...|:||                  |...||||||...:..:|||::||:.|
 Frog   299 TYLLSSGKLSMEEVYGSVVE------------------LLQAGVDTTSNTLTWALYQLSRNPEIQ 345

  Fly   413 KKLFDELQKVFPHREADINQNVLEQMPYLRACVKETLRMRPVVIANGRSL-QSDAVINGYHVPKG 476
            ..|:.|:.:|.| .|...:...:.:||.|:|.:|||||:.|||..|.|.: :.:..|..|..|..
 Frog   346 NNLYQEVIRVIP-GETIPDSEAIARMPLLKAVIKETLRLFPVVPENARMINEKEVTIKDYVFPVK 409

  Fly   477 THVIFPHLVVSNDPAYFPEPKRFLPERWLKQSTDAAGCPHANQKIHPFVSLPFGFGRRMCVGRRF 541
            |..|..|..:|.|...|||..||||||||:.|    |..|     |||.|:|||:|.|.|||||.
 Frog   410 TQFILGHYAISRDETTFPEADRFLPERWLRDS----GMKH-----HPFGSIPFGYGVRACVGRRI 465

  Fly   542 AEIELHTLLAKIFRKYKV--SYNSGEFVYRVNSTYIPQSPLNFKLTLR 587
            ||:|:|..|::|.:.::|  ..:.||...:..:..:...|:|.:...|
 Frog   466 AELEMHLALSRIIKMFQVIPDPDLGEVGAKNRAVLVANRPVNLRFIER 513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp49a1	NP_001246256.1	p450	104..565	CDD:299894	156/492 (32%)
cyp27a1.3	XP_002934001.3	cytochrome_P450	79..508	CDD:425388	148/477 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	193	1.000	Domainoid score	I3126
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H36040
Inparanoid	1	1.050	208	1.000	Inparanoid score	I3591
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9361
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.060