DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp49a1 and cyp11a2

DIOPT Version :9

Sequence 1:	NP_001246256.1	Gene:	Cyp49a1 / 36105	FlyBaseID:	FBgn0033524	Length:	589	Species:	Drosophila melanogaster
Sequence 2:	XP_021329545.1	Gene:	cyp11a2 / 563363	ZFINID:	ZDB-GENE-130911-1	Length:	512	Species:	Danio rerio

Alignment Length:	554	Identity:	144/554 - (25%)
Similarity:	253/554 - (45%)	Gaps:	100/554 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 SVATTRTTASSLPAETTSSPA-----AAVRPYSEVPGPYPLPLIGNSWR--------FAPLIGTY 125
            ||::.:.....:...:..:||     :.|||::|:||         .||        ||.:.|
Zfish    13 SVSSLKHLLQVIVTRSGRAPAIGLQDSTVRPFNEIPG---------QWRNSLKSVFAFAKMGG-- 66

  Fly   126 KISDLDKVMNELHVNYGKMAKVGGLIGHPDLLFVFDGDEIRNIFKKEEAMPHRPSMPSLRHYKGD 190
             :.::.::|......:|.:.:  ..:|..:.:.:...::...:||.|...|.|.::.:...|
Zfish    67 -LRNIHRIMVHNFNTFGPIYR--EKVGFYESVNIIKPEDAAILFKAEGHYPKRLTIDAWTAY--- 125

  Fly   191 LRRDFFGDVAGLIGVHGPKWEAFRQEVQHILLQPQTAKKYIPPLNDIASEFMGRI--ELMRDEKD 253
              ||:.....|::...|..|::.|..:...::.|:....::|.|:::..:|:.|:  ::.|..::
Zfish   126 --RDYRNRKYGVLLKDGEDWKSNRIILNKEVISPKVQGNFVPLLDEVGQDFVARVNKKIERSGQN 188

  Fly   254 ELPANFLHELYKWALESVGRVSLDTRLGCLSPEGSEEAQQIIEAINTFFWAV-PELELRMPLWRI 317
            :...:..|||:|:|||||..|....|||.|......::|:.|:.|...|... |.|.|...|.|.
Zfish   189 QWTTDLSHELFKFALESVSAVLYGERLGLLLDYIDPDSQRFIDCITLMFKTTSPMLYLPPGLLRP 253

  Fly   318 YPTKAYRSFVKALDQF---TAICMKNIGKTMDKADADEARGLSKSEADISIVERIVRKTGNRK-- 377
            ..:|.:|:.|:|.|..   ...|::||.:.:.|                       ...||.|
Zfish   254 IRSKIWRNHVEAWDGIFNQADRCIQNIYRQLRK-----------------------NPEGNGKYT 295

  Fly   378 --LAAILALD-------------LFLVGVDTTSVAASSTIYQLAKNPDKQKKLFDELQKVFPHRE 427
              ||::|.||             |...|||||::....|:|:||:|||.|:::..|:.......:
Zfish   296 GVLASLLMLDKLSIEDIKASVTELMAGGVDTTAITLLWTLYELARNPDLQEEIRAEISAARIASK 360

  Fly   428 ADINQNVLEQMPYLRACVKETLRMRPVVIANGRSLQSDAVINGYHVPKGTHVIFPHLVVSNDPAY 492
            .|:.| :|:.:|.::..:|||||:.||.::..|.:..|.||..||:|.||.|......:..|...
Zfish   361 GDMVQ-MLKMIPLVKGTLKETLRLHPVAVSLQRYITEDIVIQKYHIPAGTLVQLGLYAMGRDHQV 424

  Fly   493 FPEPKRFLPERWLKQSTDAAGCPHANQKIHPFVSLPFGFGRRMCVGRRFAEIELHTLLAKIFRKY 557
            ||.|:::||.||:            |.:.|.|.||.||||.|.|:|||.||.|:...|..:...:
Zfish   425 FPNPEQYLPSRWV------------NSQNHYFKSLSFGFGPRQCLGRRIAETEMQLFLIHMLENF 477

  Fly   558 KVSYNSGEFVYRVNSTY----IPQSPLNFKLTLR 587
            ::   ..:....|.|.:    :|:.|:  .||::
Zfish   478 RI---EKQRQMEVKSMFELILLPEKPI--MLTIK 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp49a1	NP_001246256.1	p450	104..565	CDD:299894	130/491 (26%)
cyp11a2	XP_021329545.1	p450	69..505	CDD:306555	128/483 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2609
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820