DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp49a1 and si:ch211-113j14.1

DIOPT Version :9

Sequence 1:	NP_001246256.1	Gene:	Cyp49a1 / 36105	FlyBaseID:	FBgn0033524	Length:	589	Species:	Drosophila melanogaster
Sequence 2:	XP_686522.4	Gene:	si:ch211-113j14.1 / 558239	ZFINID:	ZDB-GENE-120215-110	Length:	573	Species:	Danio rerio

Alignment Length:	613	Identity:	179/613 - (29%)
Similarity:	279/613 - (45%)	Gaps:	91/613 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RKTSIALMRR------STSSTTILPHSGGVGGAVSPPSSGVGVATEIEKSIAMQRLRTGESSNPK 63
            |||.....||      ..||:..|.|:..|...:|.......:|.:|.:..|..:.....:...:
Zfish    21 RKTRPEFDRRHLSASARQSSSDPLRHTPVVNMLISALVKADRLAAQIGRKYAPFQEMIARTLKSQ 85

  Fly    64 KLNVSQQPVTSVATTRTTASSLPAETTSSPAAAVRPYSEVPGPYPLPLIGNSWRFAPLIGTYKIS 128
            ..:|..|...::.....|...||     .|..|...|               |.|   :..|  :
Zfish    86 TGDVDLQSANTITGRYKTKDDLP-----GPNLATTVY---------------WLF---VKGY--A 125

  Fly   129 DLDKVMNELHVN-YGKMAKVGGLIGHPDLLFVFDGDEIRNIFKKEEAMPHRPSMPSLRHYKGDLR 192
            |....|...|.. ||.:.:  ...|..|::.|...|.|..:.::|...|.|..:|..|.|
Zfish   126 DKSHAMQVEHKRLYGPIWR--SRFGPFDVINVAGADLIAQVIRQEGRYPVRTDLPHWREY----- 183

  Fly   193 RDFFGDVAGLIGVHGPKWEAFRQEVQHILLQPQTAKKYIPPLNDIASEFMGRIELMR-DEKDELP 256
            ||..|...|:....||:|...|..:...:|:.:....|.|.::::.|:.:.|:||:| ...|::.
Zfish   184 RDMRGQAYGIHVDTGPEWYRIRSALNPKMLKLKEVTAYAPIIHEVVSDLLQRLELLRLRSPDQIT 248

  Fly   257 ANFL-HELYKWALESVGRVSLDTRLGCLSPEGSEEAQQIIEAINTFFWAVPELELRMPLW--RIY 318
            .:.| .||||:..|.:..:..:||||||..|...:..:.|.|:|... |:.|..|..|.|  .|:
Zfish   249 VSDLASELYKFGFEGISSILFETRLGCLQEEIPTDTLRFISAVNEML-ALSETVLFFPRWTRHIF 312

  Fly   319 PTKAYRSFVKALDQFTAICMKNIGKTMDKADADEARG----------------LSKSEADISIVE 367
            |  .::.||:|.|:...:....|.|.:::.....|||                ||..|..||:.|
Zfish   313 P--FWKRFVQAWDELYDVARHLIDKKVNEIRDQVARGEEVEGMYLTYLLSSNKLSLGEVYISLTE 375

  Fly   368 RIVRKTGNRKLAAILALDLFLVGVDTTSVAASSTIYQLAKNPDKQKKLFDELQKVFPHREADINQ 432
                              |.|.||||||...|.|:|.||:||:.||:|.:|:..|.|:::.. |.
Zfish   376 ------------------LLLGGVDTTSNTLSWTLYHLARNPEIQKRLHNEIVSVCPNKKVP-NT 421

  Fly   433 NVLEQMPYLRACVKETLRMRPVVIANGR-SLQSDAVINGYHVPKGTHVIFPHLVVSNDPAYFPEP 496
            :.|.:|||::|.:||.|||.|||..||| ::.||.|::.|..||.|.....|..||:|...||:.
Zfish   422 DDLTKMPYMKAVIKEILRMYPVVPGNGRLTVDSDIVVDNYWFPKKTQFHLCHYAVSHDENNFPDA 486

  Fly   497 KRFLPERWLKQSTDAAGCPHANQKIHPFVSLPFGFGRRMCVGRRFAEIELHTLLAKIFRKYKVSY 561
            :||:||||::.|      |..:|. ||:.|:|||.|.|.|||:|.||:|::..|:::.::|:|..
Zfish   487 ERFVPERWIRDS------PSRSQH-HPYSSVPFGVGVRACVGKRVAELEMYFALSRLMQQYEVRT 544

  Fly   562 NSG--EFVYRVNSTYIPQSPLNFKLTLR 587
            .:|  ....:..:..||..|::.:...|
Zfish   545 KAGSPSIQPKTRTLLIPSQPIDLQFIPR 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp49a1	NP_001246256.1	p450	104..565	CDD:299894	153/484 (32%)
si:ch211-113j14.1	XP_686522.4	p450	108..569	CDD:278495	160/521 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2609
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3547
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	1	0.900	-	-		OOG6_100895
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2442
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.800