Protein Alignment Cyp49a1 and Cyp12a5

DIOPT Version :10

• Sequence 1: NP_610588.2
• Gene: Cyp49a1 / 36105
• FlyBaseID: FBgn0033524
• Length: 589
• Species: Drosophila melanogaster
• Sequence 2: NP_650782.1
• Gene: Cyp12a5 / 42293
• FlyBaseID: FBgn0038680
• Length: 536
• Species: Drosophila melanogaster
• Alignment Length: 537
• Identity: 183/537 - (34%)
• Similarity: 310/537 - (57%)
• Gaps: 28/537 - (5%)

  Fly    65 LNV--SQQPVTSVATTRTTASSLP-AETTSSPA-AAVRPYSEVPGPYPLPLIGNSWRFAPLIGTY 125
            ||:  ||:|:...|:.:...:::| ||..:.|. ...:|:.|:|....|.|...|   |...|.|
  Fly     8 LNILQSQKPIVFSASQQRWQTNVPTAEIRNDPEWLQAKPFEEIPKANILSLFAKS---ALPGGKY 69

  Fly   126 KISDLDKVMNELHVNYGKMAKVGGLIGHPDLLFVFDGDEIRNIFKKEEAMPHRPSMPSLRHYKGD 190
            |..::.::::.|..:||.:..:.|::|...|:...:..:...:|:.|...|.||....||:::..
  Fly    70 KNLEMMEMIDALRQDYGNIIFLPGMMGRDGLVMTHNPKDFEVVFRNEGVWPFRPGSDILRYHRTV 134

  Fly   191 LRRDFFGDVAGLIGVHGPKWEAFRQEVQHILLQPQTAKKYIPPLNDIASEFMGRIELMRD-EKDE 254
            .|:|||..|.|:|...|..|..||..|..:|:||:..:.|...::.:..||:..|:.:|| ...|
  Fly   135 YRKDFFDGVQGIIPSQGKSWGDFRSIVNPVLMQPKNVRLYFKKMSQVNQEFVELIKEIRDASTQE 199

  Fly   255 LPANFLHELYKWALESVGRVSLDTRLGCLSPEG-SEEAQQIIEAINTFFWAVPELELRMPLWRIY 318
            :|.|||..:.:|.||||..|:||.:||.|...| :.||.::.:.::.||....:||::..|||.:
  Fly   200 VPGNFLETINRWTLESVSVVALDKQLGLLRESGKNSEATKLFKYLDEFFLHSADLEMKPSLWRYF 264

  Fly   319 PTKAYRSFVKALDQFTAICMKNIGKTMDKADADEARGLSKSEADISIVERIVRKTGNRKLAAILA 383
            .|...:..::.:|....:.:|.:.:.:::.:.:...|:.:.|.:.|::|::::.  ::|:|.::|
  Fly   265 KTPLLKKMLRTMDSVQEVTLKYVDEAIERLEKEAKEGVVRPEHEQSVLEKLLKV--DKKVATVMA 327

  Fly   384 LDLFLVGVDTTSVAASSTIYQLAKNPDKQKKLFDELQKVFPHREADINQNVLEQMPYLRACVKET 448
            :|:.:.||||||...::.:..|||||:||.:|.:|:.||.|:::::..:..::.:||||||:||:
  Fly   328 MDMLMAGVDTTSSTFTALLLCLAKNPEKQARLREEVMKVLPNKDSEFTEASMKNVPYLRACIKES 392

  Fly   449 LRMRPVVIANGRSLQSDAVINGYHVPKGTHVIFPHLVVSNDP-------AYFPEPKRFLPERWLK 506
            .|:.|:||.|.|.|..|:||:||.||.||       :||..|       .|||:|..|||||||:
  Fly   393 QRVYPLVIGNARGLTRDSVISGYRVPAGT-------IVSMIPINSLYSEEYFPKPTEFLPERWLR 450

  Fly   507 QSTDAAG-CPHANQKI-HPFVSLPFGFGRRMCVGRRFAEIELHTLLAKIFRKYKVSYN-SGEFVY 568
            .::|:|| ||..:.|. :|||.||||||.|||||:|..|:||....|::.|.:.|.:| |.:..:
  Fly   451 NASDSAGKCPANDLKTKNPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEFNHSTKNAF 515

  Fly   569 RVNSTYIPQSPLNFKLT 585
            |.....:|..||.||.|
  Fly   516 RSALINLPNIPLKFKFT 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp49a1	NP_610588.2	CYP24A1-like	138..581	CDD:410677	158/454 (35%)
Cyp12a5	NP_650782.1	CYP24A1-like	82..528	CDD:410677	158/454 (35%)