DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp49a1 and Cyp313a4

DIOPT Version :9

Sequence 1:	NP_001246256.1	Gene:	Cyp49a1 / 36105	FlyBaseID:	FBgn0033524	Length:	589	Species:	Drosophila melanogaster
Sequence 2:	NP_650224.3	Gene:	Cyp313a4 / 41563	FlyBaseID:	FBgn0038076	Length:	494	Species:	Drosophila melanogaster

Alignment Length:	515	Identity:	115/515 - (22%)
Similarity:	199/515 - (38%)	Gaps:	141/515 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 EVPGPYPLPLIGNS-W--RFAPLIGTYKISDLDKVMNELHVNYGKMAKVGGLIGHPDLLFVFDGD 163
            ::|||...|::|.: |  |...::..:... |||        :|  ..:...:|....:.|.|..
  Fly    31 KIPGPLGYPILGMAHWLMRREDILNAFGCF-LDK--------HG--PTIFSWLGPIPFMIVSDPQ 84

  Fly   164 EIRNIFKKEEAMPHRPSMPSLRHYKGDLRRDFFGDVAGLIGVHGPKWEAFRQEVQHILLQPQTAK 228
            .:::||    ..||..:...:.....|      |...||..:..|:|...|:     ||.|....
  Fly    85 VVQDIF----TSPHCVNKGIIYKAVDD------GAGVGLFSLKDPRWSIHRK-----LLNPAFGH 134

  Fly   229 K----YIPPLNDIASEFMGRIELMRD--EKDELP--------------------------ANFLH 261
            |    ::|..|...:..:.::|.::|  |||.:|                          :|.|.
  Fly   135 KVLLSFLPIFNRETALLLDQLEPLQDDGEKDLIPLLQSFTLGIATQTTMGSDVKDEESFRSNSLL 199

  Fly   262 ELYKWALESVGRVSLDTRLGCLSP-EGSEEAQQIIEAINTFFWAVPELELRMPLWRIYPTKAYRS 325
            ..|:..||::..:       |.|| ..|...:|:....:.::.|..|:               |.
  Fly   200 GRYQCILETMTDM-------CFSPWLNSRFCRQLAGKESHYYQAKTEI---------------RQ 242

  Fly   326 FVKALDQFTAICMKNIGKTMDKADADEARGLSKSEADISIVERIVRKTGNRKLAAILALDLFLVG 390
            |::              |.:::..|::..|...|           .::.::.|...|..||...|
  Fly   243 FIR--------------KIIERKLAEDEMGALPS-----------IQSNDKNLFLNLVTDLMRRG 282

  Fly   391 V------------------DTTSVAASSTIYQLAKNPDKQKKLFDELQKVFPHR-EADINQNVLE 436
            |                  :||:.|...|:..||..|:.|::.|:|::.:||:. :.|::....:
  Fly   283 VFTLKNVEDESNIIVFGAFETTANAVYYTLMLLAMFPEYQERAFEEIKTIFPNTGDFDVSYADTQ 347

  Fly   437 QMPYLRACVKETLRMRPVVIANGRSLQSDAVI-NGYHVPKGTHVIFP--HLVVSNDPAYFPEPKR 498
            ||.||...:.|::|:.|.|....|....|..: ||..||||..:...  |:..|. ..:.|:.:.
  Fly   348 QMVYLDLILNESMRVIPPVPVVSRQTSQDLKLSNGIVVPKGVQIAIDIYHMHRSK-KIWGPDAET 411

  Fly   499 FLPERWLKQSTDAAGCPHANQKIHPFVSLPFGFGRRMCVGRRFAEIELHTLLAKIFRKYK 558
            |.|:.:|         ||..|..||:..:||..|.|.|:|.|:|.|.....|||:.|.|:
  Fly   412 FNPDHFL---------PHNIQDKHPYAYIPFTKGIRNCIGWRYALISAKVTLAKLLRNYR 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp49a1	NP_001246256.1	p450	104..565	CDD:299894	115/513 (22%)
Cyp313a4	NP_650224.3	p450	33..465	CDD:299894	115/513 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24305
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100