Protein Alignment Cyp49a1 and cyp27a7

DIOPT Version :9

• Sequence 1: NP_001246256.1
• Gene: Cyp49a1 / 36105
• FlyBaseID: FBgn0033524
• Length: 589
• Species: Drosophila melanogaster
• Sequence 2: XP_002663445.1
• Gene: cyp27a7 / 402831
• ZFINID: ZDB-GENE-081104-519
• Length: 524
• Species: Danio rerio
• Alignment Length: 471
• Identity: 144/471 - (30%)
• Similarity: 230/471 - (48%)
• Gaps: 45/471 - (9%)

  Fly   134 MNELHVN----YGKMAKVGGLIGHPDLLFVFDGDEIRNIFKKEEAMPHRPSMPSLRHYKGDLRRD 194
            |:||.:.    ||.:.|:.  :|:...:.:...|.:..:.:|:|..|.|..|.....|     ||
Zfish    77 MHELQLYEKQLYGPLYKIN--VGNFQSVALNSVDLLEELLRKDEKFPSRGDMTLWTEY-----RD 134

  Fly   195 FFGDVAGLIGVHGPKWEAFRQEVQHILLQPQTAKKYIPPLNDIASEFMGRIELMRD--EKDELPA 257
            ..|...|.....|.||...|..:...:|.|:.:.:|...:|.:.::|:.||..:|:  ...:|.:
Zfish   135 MKGIGYGPFTEEGEKWYKLRAVLNKRMLHPKDSVQYGDVVNAVITDFIKRIYYLREMSPTGDLVS 199

  Fly   258 NFLHELYKWALESVGRVSLDTRLGCLSPEGSEEAQQIIEAI-NTFFWAVPELELRMPLWRIYPTK 321
            |..:|||:::||.:..:..:||:|||..|...|.|..|.:| ....:::|  .:.||.|    |:
Zfish   200 NLTNELYRFSLEGISSILFETRIGCLEKEIPAETQHFINSIAQMLTYSMP--VVFMPNW----TR 258

  Fly   322 AYRSF-VKALDQFTAICMKNIGKTMD-KADADEARGLSKSEADISIVERIVRKTGNRKLAAI--- 381
            .|..| .:.:..:..| .|..||.:| |.:|.:.|..:..|.   ..|.:.....|.|:::.
Zfish   259 NYLPFWQRYIGGWDGI-FKFAGKMIDMKMEALQKRVDANQEV---AGEYLTYLLSNGKMSSKDVY 319

  Fly   382 -LALDLFLVGVDTTSVAASSTIYQLAKNPDKQKKLFDELQKVFPHREADINQNVLEQMPYLRACV 445
             ...:|.|.||||||......:|.|:|:|:.|..|:.|:..|.........|.| ..|.||:|.:
Zfish   320 GSVSELLLAGVDTTSNTMLFALYHLSKDPETQDILYQEVTNVLKDDRIPTAQEV-NTMSYLKAVI 383

  Fly   446 KETLRMRPVVIANGRSL-QSDAVINGYHVPKGTHVIFPHLVVSNDPAYFPEPKRFLPERWLKQST 509
            |||||:.|||..|.|.: :::.||.|:..||.|.....|..:|.|...||||::|.|||||:.
Zfish   384 KETLRLYPVVPMNARLIAENEVVIGGHLFPKNTTFTLCHYAISRDEKVFPEPQKFKPERWLRD-- 446

  Fly   510 DAAGCPHANQKIHPFVSLPFGFGRRMCVGRRFAEIELHTLLAKIFRKYKVSYNS--GEFVYRVNS 572
                   ...:.:||.|:|||||.|.|||||.||:|::..||::.:.:::..:.  || |..:|.
Zfish   447 -------GRTRPNPFGSIPFGFGVRGCVGRRIAELEMYLALARLIKLFEIRPDPTVGE-VRSLNR 503

  Fly   573 TYI-PQSPLNFKLTLR 587
            |.: |...:|.....|
Zfish   504 TVLAPDRKVNLHFVER 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp49a1	NP_001246256.1	p450	104..565	CDD:299894	136/446 (30%)
cyp27a7	XP_002663445.1	p450	68..507	CDD:278495	141/457 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2609
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H36040
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3547
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	1	0.900	-	-		OOG6_100895
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.770