Protein Alignment Cyp49a1 and cyp27a1.1

DIOPT Version :10

• Sequence 1: NP_610588.2
• Gene: Cyp49a1 / 36105
• FlyBaseID: FBgn0033524
• Length: 589
• Species: Drosophila melanogaster
• Sequence 2: XP_002663445.1
• Gene: cyp27a1.1 / 402831
• ZFINID: ZDB-GENE-081104-519
• Length: 524
• Species: Danio rerio
• Alignment Length: 471
• Identity: 144/471 - (30%)
• Similarity: 230/471 - (48%)
• Gaps: 45/471 - (9%)

  Fly   134 MNELHVN----YGKMAKVGGLIGHPDLLFVFDGDEIRNIFKKEEAMPHRPSMPSLRHYKGDLRRD 194
            |:||.:.    ||.:.|:.  :|:...:.:...|.:..:.:|:|..|.|..|.....|     ||
Zfish    77 MHELQLYEKQLYGPLYKIN--VGNFQSVALNSVDLLEELLRKDEKFPSRGDMTLWTEY-----RD 134

  Fly   195 FFGDVAGLIGVHGPKWEAFRQEVQHILLQPQTAKKYIPPLNDIASEFMGRIELMRD--EKDELPA 257
            ..|...|.....|.||...|..:...:|.|:.:.:|...:|.:.::|:.||..:|:  ...:|.:
Zfish   135 MKGIGYGPFTEEGEKWYKLRAVLNKRMLHPKDSVQYGDVVNAVITDFIKRIYYLREMSPTGDLVS 199

  Fly   258 NFLHELYKWALESVGRVSLDTRLGCLSPEGSEEAQQIIEAI-NTFFWAVPELELRMPLWRIYPTK 321
            |..:|||:::||.:..:..:||:|||..|...|.|..|.:| ....:::|  .:.||.|    |:
Zfish   200 NLTNELYRFSLEGISSILFETRIGCLEKEIPAETQHFINSIAQMLTYSMP--VVFMPNW----TR 258

  Fly   322 AYRSF-VKALDQFTAICMKNIGKTMD-KADADEARGLSKSEADISIVERIVRKTGNRKLAAI--- 381
            .|..| .:.:..:..| .|..||.:| |.:|.:.|..:..|.   ..|.:.....|.|:::.
Zfish   259 NYLPFWQRYIGGWDGI-FKFAGKMIDMKMEALQKRVDANQEV---AGEYLTYLLSNGKMSSKDVY 319

  Fly   382 -LALDLFLVGVDTTSVAASSTIYQLAKNPDKQKKLFDELQKVFPHREADINQNVLEQMPYLRACV 445
             ...:|.|.||||||......:|.|:|:|:.|..|:.|:..|.........|.| ..|.||:|.:
Zfish   320 GSVSELLLAGVDTTSNTMLFALYHLSKDPETQDILYQEVTNVLKDDRIPTAQEV-NTMSYLKAVI 383

  Fly   446 KETLRMRPVVIANGRSL-QSDAVINGYHVPKGTHVIFPHLVVSNDPAYFPEPKRFLPERWLKQST 509
            |||||:.|||..|.|.: :::.||.|:..||.|.....|..:|.|...||||::|.|||||:.
Zfish   384 KETLRLYPVVPMNARLIAENEVVIGGHLFPKNTTFTLCHYAISRDEKVFPEPQKFKPERWLRD-- 446

  Fly   510 DAAGCPHANQKIHPFVSLPFGFGRRMCVGRRFAEIELHTLLAKIFRKYKVSYNS--GEFVYRVNS 572
                   ...:.:||.|:|||||.|.|||||.||:|::..||::.:.:::..:.  || |..:|.
Zfish   447 -------GRTRPNPFGSIPFGFGVRGCVGRRIAELEMYLALARLIKLFEIRPDPTVGE-VRSLNR 503

  Fly   573 TYI-PQSPLNFKLTLR 587
            |.: |...:|.....|
Zfish   504 TVLAPDRKVNLHFVER 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp49a1	NP_610588.2	CYP24A1-like	138..581	CDD:410677	139/459 (30%)
cyp27a1.1	XP_002663445.1	cytochrome_P450	85..514	CDD:477761	139/456 (30%)