DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp49a1 and shd

DIOPT Version :9

Sequence 1:	NP_001246256.1	Gene:	Cyp49a1 / 36105	FlyBaseID:	FBgn0033524	Length:	589	Species:	Drosophila melanogaster
Sequence 2:	NP_001261843.1	Gene:	shd / 39592	FlyBaseID:	FBgn0003388	Length:	540	Species:	Drosophila melanogaster

Alignment Length:	514	Identity:	131/514 - (25%)
Similarity:	244/514 - (47%)	Gaps:	44/514 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 SPAAAVRPYSEVPGPYPLPLIGNSWRFAPLIGTYKISDLDKVMNELHVNYGKMAKVGGLIGHPDL 156
            :|....|...::|||..:|.:|..|.|......||::.|.:|..:|:..||.:. :..:..:..:
  Fly    51 APKRRRRGIWDIPGPKRIPFLGTKWIFLLFFRRYKMTKLHEVYADLNRQYGDIV-LEVMPSNVPI 114

  Fly   157 LFVFDGDEIRNIFKKEEAMPHRPSMPSLRHYKGDLRRDFFGDVAGLIGVHGPKWEAFRQEVQHIL 221
            :.:::.|::..:.|.....|.||....:..|: ..|.|.:..| |::...||.|:..|..:...:
  Fly   115 VHLYNRDDLEKVLKYPSKYPFRPPTEIIVMYR-QSRPDRYASV-GIVNEQGPMWQRLRSSLTSSI 177

  Fly   222 LQPQTAKKYIPPLNDIASEFMGRIELMRDEKDE---LPANFLHELYKWALESVGRVSLDTRLGCL 283
            ..|:..:.::|.||.:..:|   |||:|..:|.   :..||........||:|..:.|..|:|.|
  Fly   178 TSPRVLQNFLPALNAVCDDF---IELLRARRDPDTLVVPNFEELANLMGLEAVCTLMLGRRMGFL 239

  Fly   284 S--PEGSEEAQQIIEAINTFFWAVPELELRMPLWRIYPTKAYRSFVKALDQFTAICMKNIGKTMD 346
            :  .:..::..|:..|:...|.:..:....:.||:.:|||.||.|.:|.|....:..:.|...::
  Fly   240 AIDTKQPQKISQLAAAVKQLFISQRDSYYGLGLWKYFPTKTYRDFARAEDLIYDVISEIIDHELE 304

  Fly   347 K------ADADEARGLSKSEADISIVERIVRKTGNRKLAAILALDLFLVGVDTTSVAASSTIYQL 405
            :      .:.|||.||  ....::|:|.......::|.|.|   |....|::|.:......:..:
  Fly   305 ELKKSAACEDDEAAGL--RSIFLNILELKDLDIRDKKSAII---DFIAAGIETLANTLLFVLSSV 364

  Fly   406 AKNPDKQKKLFDELQKVFPHREADINQNVLEQMPYLRACVKETLRMRPVVIANGRSLQSDAVING 470
            ..:|....::..|..:   :|:.:|.|:.|....|.:||::|:.|:||......|.|:.|..::|
  Fly   365 TGDPGAMPRILSEFCE---YRDTNILQDALTNATYTKACIQESYRLRPTAFCLARILEEDMELSG 426

  Fly   471 YHVPKGTHVIFPHLVVSNDPAYFPEPKRFLPERWLKQSTD--AAGCPHANQKIHPFVSLPFGFGR 533
            |.:..||.|:..:::..:..:.|...|:|.||||:..:|:  .....:|:      :.:|||.||
  Fly   427 YSLNAGTVVLCQNMIACHKDSNFQGAKQFTPERWIDPATENFTVNVDNAS------IVVPFGVGR 485

  Fly   534 RMCVGRRFAEIELHTLLAKIFRKYKVSY-----NSGEFVYRVNSTYIPQSPLNFKLTLR 587
            |.|.|:||.|:|:..||||:...:.||:     ...||:      ..|::||:.:|:.|
  Fly   486 RSCPGKRFVEMEVVLLLAKMVLAFDVSFVKPLETEFEFL------LAPKTPLSLRLSDR 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp49a1	NP_001246256.1	p450	104..565	CDD:299894	122/478 (26%)
shd	NP_001261843.1	p450	63..528	CDD:299894	124/490 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28158
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24305
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.930