DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cyp49a1 and Cyp12b2

DIOPT Version :9

Sequence 1:NP_001246256.1 Gene:Cyp49a1 / 36105 FlyBaseID:FBgn0033524 Length:589 Species:Drosophila melanogaster
Sequence 2:NP_611370.2 Gene:Cyp12b2 / 37163 FlyBaseID:FBgn0034387 Length:535 Species:Drosophila melanogaster


Alignment Length:530 Identity:170/530 - (32%)
Similarity:281/530 - (53%) Gaps:53/530 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    67 VSQQPVTSVATTRTTASSLPAETTSSPAAAVRPYSEVPGPYPLPLI-----GNSWRFAPLIGTYK 126
            :|||....:|.:|.......|          |.:.|:|||..|.::     |.:.|...||    
  Fly    30 LSQQTQLELADSRIDEKWQQA----------RSFGEIPGPSLLRMLSFFMPGGALRNTNLI---- 80

  Fly   127 ISDLDKVMNELHVNYGKMAKVGGLIGHPDLLFVFDGDEIRNIFKKEEAMPHRPSMPSLRHYKGDL 191
              .::::|.|:   ||.:..:.|::|.|:.:|.::.|:....::.|...|.|..:.||.:|:...
  Fly    81 --QMNRLMREM---YGDIYCIPGMMGKPNAVFTYNPDDFEMTYRNEGVWPIRIGLESLNYYRKIH 140

  Fly   192 RRDFFGDVAGLIGVHGPKWEAFRQEVQHILLQPQTAKKYIPPLNDIASEFMGRIELMRD-EKDEL 255
            |.|.|..|.||....|.:|...|.:|..:|::.|..::.:|.|:.|:.||:.::|..|: |...|
  Fly   141 RPDVFKGVGGLASDQGQEWADIRNKVNPVLMKVQNVRQNLPQLDQISKEFIDKLETQRNPETHTL 205

  Fly   256 PANFLHELYKWALESVGRVSLDTRLGCLSPEGSEEAQQIIEAINTFFWAVPELELRMPLWRIYPT 320
            ..:|.::|..||.||:..|:|:||:|.||......|.::.:.:..||....:.:::..:|..|.|
  Fly   206 TTDFHNQLKMWAFESISFVALNTRMGLLSDNPDPNADRLAKHMRDFFNYSFQFDVQPSIWTFYKT 270

  Fly   321 KAYRSFVKALDQFTAICMKNIGKTMDKADADEARGLSKSEADIS--IVERIVRKTGNRKLAAILA 383
            ..::.|:|..|..|.|....|...|        ||..|::...:  ::|:::..  |:|:|..:.
  Fly   271 AGFKKFLKTYDNITDITSNYIETAM--------RGFGKNDDGKTKCVLEQLLEH--NKKVAVTMV 325

  Fly   384 LDLFLVGVDTTSVAASSTIYQLAKNPDKQKKLFDELQKVFPHREADINQNVLEQMPYLRACVKET 448
            :|:.:.|:||||.|..:.:|.||:||.||:||..||.::.|..:..:.....:.|||||||:||.
  Fly   326 MDMLMAGIDTTSSACLTILYHLARNPSKQEKLRRELLRILPTTKDSLTDQNTKNMPYLRACIKEG 390

  Fly   449 LRMRPVVIANGRSLQSDAVINGYHVPKGTHVIFPHLVVSNDPAYFPEPKRFLPERWLKQ--STDA 511
            ||:..:...|.|....|.|::||.||:||.|:...|.:|||..||.:...|:||||||.  :.|.
  Fly   391 LRITSITPGNFRITPKDLVLSGYQVPRGTGVLMGVLELSNDDKYFAQSSEFIPERWLKSDLAPDI 455

  Fly   512 AGCPHANQKIHPFVSLPFGFGRRMCVGRRFAEIELHTLLAKIFRKYKVSYNSGEFVYRVNSTYIP 576
            ..||.|..: :|||.||||||.|.|:|:|.||:|:.|||.::.|.||||             ::|
  Fly   456 QACPAARTR-NPFVYLPFGFGPRTCIGKRIAELEIETLLVRLLRSYKVS-------------WLP 506

  Fly   577 QSPLNFKLTL 586
            ::|:.::.|:
  Fly   507 ETPIEYESTI 516

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cyp49a1NP_001246256.1 p450 104..565 CDD:299894 159/470 (34%)
Cyp12b2NP_611370.2 p450 59..511 CDD:299894 159/484 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 217 1.000 Domainoid score I2609
eggNOG 1 0.900 - - E2759_KOG0159
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 219 1.000 Inparanoid score I3547
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D185685at33208
OrthoFinder 1 1.000 - - FOG0000720
OrthoInspector 1 1.000 - - mtm6352
orthoMCL 1 0.900 - - OOG6_100895
Panther 1 1.100 - - P PTHR24305
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X156
109.870

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