DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp49a1 and Cyp6a13

DIOPT Version :9

Sequence 1:	NP_001246256.1	Gene:	Cyp49a1 / 36105	FlyBaseID:	FBgn0033524	Length:	589	Species:	Drosophila melanogaster
Sequence 2:	NP_610390.1	Gene:	Cyp6a13 / 35837	FlyBaseID:	FBgn0033304	Length:	493	Species:	Drosophila melanogaster

Alignment Length:	521	Identity:	122/521 - (23%)
Similarity:	209/521 - (40%)	Gaps:	105/521 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 VPGPYPLPLIGNSWRFAPLIGTYKISDLDKVMNELHVN---YGKMAKVGGLIGH----PDLLFVF 160
            |.|..|:...||            :|.|.:.::...:|   |.|...|....|:    ...||:.
  Fly    31 VAGERPVYFRGN------------MSGLGRDLHWTDINLRIYRKFRGVERYCGYFTFMTKSLFIM 83

  Fly   161 DGDEIRNIFKKEEAMPHRPSMPSLRHYKGDLRRDFFGDV------AGLIGVHGPKWEAFRQEVQH 219
            |.:.||:|.              :|.:.....|..|.:|      ..|:.:.||:|...||.:..
  Fly    84 DLELIRDIM--------------IRDFSSFADRGLFHNVRDDPLTGNLLFLDGPEWRWLRQNLTQ 134

  Fly   220 ILLQPQTAKKYIPPLNDIASEFMG--RIELMRDEKDELPANFLHELYKWALESVGRVSLDTRLGC 282
            :....: .|...|.:.::..:...  |:::...|..:|.|.|..::       :|..:.......
  Fly   135 VFTSGK-MKFMFPNMVEVGEKLTQACRLQVGEIEAKDLCARFTTDV-------IGSCAFGLECNS 191

  Fly   283 L-SPE------GSEEAQQIIEA--INTFFWAVPEL--ELRMPLWRIYPTKAYRSFVKALDQFTAI 336
            | .||      |....|:.:.:  :..|.:|.|||  :||..|:|              .:.:..
  Fly   192 LQDPESQFRRMGRSVTQEPLHSVLVQAFMFAQPELARKLRFRLFR--------------PEVSEF 242

  Fly   337 CMKNIGKTMDKADADEARGLSKSEADISIVERIVRKTGNRKLAAILALDLFLVGVDTTSVAASST 401
            .:..:.:|:|....:........:..:.:.|..|:...:.:..|..||..||.|.||:|...|..
  Fly   243 FLDTVRQTLDYRRRENIHRNDLIQLLMELGEEGVKDALSFEQIAAQALVFFLAGFDTSSTTMSFC 307

  Fly   402 IYQLAKNPDKQKKLFDELQKVFPHREADINQNVLEQMPYLRACVKETLRMRPVVIANGRSLQSDA 466
            :|:||.|||.|::|..|:..|.......:..:.:::||||...|.||||..|::....|....:
  Fly   308 LYELALNPDVQERLRVEVLAVLKRNNQKLTYDSVQEMPYLDQVVAETLRKYPILPHLLRRSTKE- 371

  Fly   467 VINGYHVPK-------GTHVIFPHLVVSNDPAYFPEPKRFLPERWLKQSTDAAGCPHANQKIHPF 524
                |.:|.       |:.:|.|...:.:||..:|:|::|.|.|:..:...|.         |||
  Fly   372 ----YQIPNSNLILEPGSKIIIPVHSIHHDPELYPDPEKFDPSRFEPEEIKAR---------HPF 423

  Fly   525 VSLPFGFGRRMCVGRRFAEIELHTLLAKIFRKYKVSYNSGEFVYRVNSTYIPQ--SPLNFKLTLR 587
            ..||||.|.|.|:|.||.::::...|..:.|.:|.|        |...|.||.  |..||.::.:
  Fly   424 AYLPFGEGPRNCIGERFGKLQVKVGLVYLLRDFKFS--------RSEKTQIPLKFSSRNFLISTQ 480

  Fly   588 D 588
            :
  Fly   481 E 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp49a1	NP_001246256.1	p450	104..565	CDD:299894	114/493 (23%)
Cyp6a13	NP_610390.1	p450	33..476	CDD:278495	120/512 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910