DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp49a1 and npp-24

DIOPT Version :9

Sequence 1:	NP_001246256.1	Gene:	Cyp49a1 / 36105	FlyBaseID:	FBgn0033524	Length:	589	Species:	Drosophila melanogaster
Sequence 2:	NP_001379685.1	Gene:	npp-24 / 3564830	WormBaseID:	WBGene00022672	Length:	655	Species:	Caenorhabditis elegans

Alignment Length:	357	Identity:	75/357 - (21%)
Similarity:	132/357 - (36%)	Gaps:	96/357 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 GGLIGHPDLLFVFDGD--EIRNIFKKEEAMPHRPSMP-----SLRHYKGDLRRDFFGDVAGLIGV 205
            ||::.|   |.||..:  |.|.:.|.:..:|.....|     .:|..|  :.|......:.|..|
Worm   273 GGVLSH---LVVFPNEFGEFRFLVKDQLRLPSSNGDPRIVQNQIRSLK--VSRYEIATSSSLFSV 332

  Fly   206 H-GPKWEAFRQEVQHILLQPQTAKKYIPPLND--IASEFMGRI------------------ELMR 249
            : .|.:||.........|:.:|.   :..|.|  |.|:.:...                  .|..
Worm   333 NIFPWFEALTSISPTSTLEKETR---VSELVDAVIPSDELSNTTKWTGARALRAVSVQLTQSLAT 394

  Fly   250 DEKDELP--ANFLH------------ELYK-------WALE---SVGR-----------VSLDTR 279
            :|::.||  .|.:|            .|:.       |:.|   |.||           .||:.:
Worm   395 EEEELLPESENIMHLVILENKDGQPAHLFNISTFDNIWSTENKTSFGRDSVSQPPMKSTGSLEQQ 459

  Fly   280 LGCLSPEG----SEE--AQQIIEAINTFFWAVPE-LELRMPLWRIYPTK--AYRSFVKALDQFTA 335
            |..|.|..    ||:  .::.|:|...||.||.| |:....:.:::..:  |..|..:|||:..
Worm   460 LAALKPLAACVISEKVSCEEAIDAAMKFFDAVDERLKKHCEISKLFVERCLAVSSSAQALDEKQ- 523

  Fly   336 ICMKNIGKTMDKADADEARGLSKSEADISIVERIVRKTGNRKLAAILALDLFLVGVDTTSVAASS 400
                   :::|:...:|..  :..|..|.:.|...|..|.||     .:::....|| .:|..|.
Worm   524 -------QSVDQRLIEETN--TVEELKIRMHETKERMEGARK-----GINVLFHRVD-ENVPLSD 573

  Fly   401 TIYQLAKNPDKQKKLFDELQKVFPHREADINQ 432
            ...::.:...:.:|:..::.|:.|....|.|:
Worm   574 NEIRIFERLKEHQKMLSDMTKLVPKMTLDSNE 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp49a1	NP_001246256.1	p450	104..565	CDD:299894	75/357 (21%)
npp-24	NP_001379685.1	Nup88	26..>212	CDD:401976
npp-24	NP_001379685.1	Smc	<455..>653	CDD:224117	38/167 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900