DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp49a1 and CYP26C1

DIOPT Version :9

Sequence 1:	NP_001246256.1	Gene:	Cyp49a1 / 36105	FlyBaseID:	FBgn0033524	Length:	589	Species:	Drosophila melanogaster
Sequence 2:	NP_899230.2	Gene:	CYP26C1 / 340665	HGNCID:	20577	Length:	522	Species:	Homo sapiens

Alignment Length:	500	Identity:	111/500 - (22%)
Similarity:	182/500 - (36%)	Gaps:	121/500 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 PLPLIGNSWRFAPLIG--TYKISDLDKVMNELHVNYGKMAKVGGLIGHPDLLFVFDGDEIRNIFK 170
            |||.....|   |..|  .:.:....:..:.....||.:.|. .|:|.| ::.|...:.:|.|..
Human    48 PLPKGSMGW---PFFGETLHWLVQGSRFHSSRRERYGTVFKT-HLLGRP-VIRVSGAENVRTILL 107

  Fly   171 KEEAMPHRPSMPSLRHYKGDLRRDFFGDVAGLIGVH---GPKWEAF--RQEVQHILLQPQTAKKY 230
            .|..:. |...|...|.              |:|.|   |...|..  |::|...:......::|
Human   108 GEHRLV-RSQWPQSAHI--------------LLGSHTLLGAVGEPHRRRRKVLARVFSRAALERY 157

  Fly   231 IPPLNDIASEFMGRIELMRDEKDELPANFLHELYKW----------------ALESVGRVSLDTR 279
            :|.|       .|.:.              ||:..|                ......|:.|..|
Human   158 VPRL-------QGALR--------------HEVRSWCAAGGPVSVYDASKALTFRMAARILLGLR 201

  Fly   280 LGCLSPEGSEEAQQIIEAINTFFWAVPELELRMPLWRIYPTKAYRSFVKALDQFTAICMKNI-GK 343
            |        :|||....| .||...|..| ..:||  ..|....|..::|.||.    .::: |.
Human   202 L--------DEAQCATLA-RTFEQLVENL-FSLPL--DVPFSGLRKGIRARDQL----HRHLEGA 250

  Fly   344 TMDKADADEARGLSKSEADISIVERIVRKTGNRKLAAIL---ALDLFLVGVDTTSVAASSTIYQL 405
            ..:|...|:|   ::....:.::....|:.|:......|   |::|......||:.|::|.:..|
Human   251 ISEKLHEDKA---AEPGDALDLIIHSARELGHEPSMQELKESAVELLFAAFFTTASASTSLVLLL 312

  Fly   406 AKNPDKQKKLFDELQKVFPHR---------------------EADINQNVLEQMPYLRACVKETL 449
            .::|....|:.:||......|                     |.|::...|.::.|:...|||.|
Human   313 LQHPAAIAKIREELVAQGLGRACGCAPGAAGGSEGPPPDCGCEPDLSLAALGRLRYVDCVVKEVL 377

  Fly   450 RMRPVVIANGRSLQSDAVINGYHVPKGTHVIF----PHLVVSNDPAYFPEPKRFLPERWLKQSTD 510
            |:.|.|....|:......::||.:|||..|::    .|...:   .|...|:.|.|||:.....|
Human   378 RLLPPVSGGYRTALRTFELDGYQIPKGWSVMYSIRDTHETAA---VYRSPPEGFDPERFGAARED 439

  Fly   511 AAGCPHANQKIHPFVSLPFGFGRRMCVGRRFAEIELHTLLAKIFR 555
            :.|   |:.:.|   .:|||.|.|.|:|:..|:..|..|..::.|
Human   440 SRG---ASSRFH---YIPFGGGARSCLGQELAQAVLQLLAVELVR 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp49a1	NP_001246256.1	p450	104..565	CDD:299894	110/499 (22%)
CYP26C1	NP_899230.2	p450	40..504	CDD:299894	110/499 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D574756at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010