Protein Alignment Cyp49a1 and cyp27a1.4

DIOPT Version :9

• Sequence 1: NP_001246256.1
• Gene: Cyp49a1 / 36105
• FlyBaseID: FBgn0033524
• Length: 589
• Species: Drosophila melanogaster
• Sequence 2: NP_001315442.1
• Gene: cyp27a1.4 / 322341
• ZFINID: ZDB-GENE-030131-1060
• Length: 522
• Species: Danio rerio
• Alignment Length: 464
• Identity: 137/464 - (29%)
• Similarity: 221/464 - (47%)
• Gaps: 45/464 - (9%)

  Fly   141 YGKMAKV--GGLIGHPDLLFVFDGDEIRNIFKKEEAMPHRPSMPSLRHYKGDLRRDFFGDVAGLI 203
            ||.:.|:  |.|.|    :.:...:.:..:.:|:|..|.|..|.....:     ||..|...|..
Zfish    86 YGPLWKINAGNLQG----ISITSVELLEELLRKDEKYPCRGYMTLWTEH-----RDLRGISYGPF 141

  Fly   204 GVHGPKWEAFRQEVQHILLQPQTAKKYIPPLNDIASEFMGRIELMRD--EKDELPANFLHELYKW 266
            ...|.||...|..:...:|.|:.:.:|...:|.:.::|:.||..:|:  ...:|.:|..:|||::
Zfish   142 TEEGEKWYKLRAVLNKRMLHPKDSLQYGDVVNAVITDFIKRIYYLREMSPTGDLVSNLTNELYRF 206

  Fly   267 ALESVGRVSLDTRLGCLSPEGSEEAQQIIEAINTFFWAVPELELRMPLWRIYPTKAYRSF-VKAL 330
            :||.:..:..:||:|||..|...|.|:.|.:|...|.....:.| :|.|    |:.|..| .|.:
Zfish   207 SLEGIASILFETRIGCLEKEIPAETQEFINSIAQMFTYNMHVAL-LPNW----TRNYLPFWQKYI 266

  Fly   331 DQFTAIC-----MKNIGKTMDKADADEARGLSKSEADISIVERIVRKTGNRKLAAIL--ALDLFL 388
            |.:..|.     |.|:     |.:|.:.|..:..|.....:..:: .:|......:.  ..::.|
Zfish   267 DGWDGIFKFGTKMINL-----KMEAIQTRLDTNQEVAGEYLTYLL-SSGKMSCKDVYGSVSEVLL 325

  Fly   389 VGVDTTSVAASSTIYQLAKNPDKQKKLFDELQKVFPHREADINQNVLEQMPYLRACVKETLRMRP 453
            .||||||......:|.|:|:|..|:.|..|:.||.........:.| ..||:|:|.:|||||:.|
Zfish   326 AGVDTTSNTMLWALYLLSKDPAAQETLHQEVTKVLKGDRIPTAEEV-NSMPFLKAVIKETLRLYP 389

  Fly   454 VVIANGRSL-QSDAVINGYHVPKGTHVIFPHLVVSNDPAYFPEPKRFLPERWLKQSTDAAGCPHA 517
            ||..|.|.: :|:.:|..|..||.|.....|..:|:|...||||::|.|||||:.         .
Zfish   390 VVPVNSRLIAESEVIIGEYLFPKKTTFNLFHYAISHDEKVFPEPQKFKPERWLRD---------G 445

  Fly   518 NQKIHPFVSLPFGFGRRMCVGRRFAEIELHTLLAKIFRKYKVSYNS--GEFVYRVNSTYIPQSPL 580
            ..:.:||.|:|||||.|.|||||.||:|:|..||::.:.:::..:.  ||......|..:|...:
Zfish   446 RTRPNPFGSIPFGFGVRACVGRRIAELEMHLALARLIKLFEMRPDPTVGEVKANFRSVLVPNKKV 510

  Fly   581 NFKLTLRDE 589
            |.....|.:
Zfish   511 NLHFVERQK 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp49a1	NP_001246256.1	p450	104..565	CDD:299894	131/438 (30%)
cyp27a1.4	NP_001315442.1	p450	66..505	CDD:278495	134/448 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2609
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H36040
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3547
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	1	0.900	-	-		OOG6_100895
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.770