DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp49a1 and Cyp27a1

DIOPT Version :9

Sequence 1:	NP_001246256.1	Gene:	Cyp49a1 / 36105	FlyBaseID:	FBgn0033524	Length:	589	Species:	Drosophila melanogaster
Sequence 2:	NP_849178.2	Gene:	Cyp27a1 / 301517	RGDID:	727915	Length:	533	Species:	Rattus norvegicus

Alignment Length:	536	Identity:	151/536 - (28%)
Similarity:	252/536 - (47%)	Gaps:	66/536 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 SSLPA-----ETTSSPAAA-----VRPYSEVPGPYPLPLIGNSWRFAPLIGTYKISDLDKVMNEL 137
            :::||     |:|..|...     :|..:|:|||..|..:...:....::..:::..|:|
  Rat    32 AAIPAALRDHESTEGPGTGQDRPRLRSLAELPGPGTLRFLFQLFLRGYVLHLHELQALNK----- 91

  Fly   138 HVNYGKMAKVGGLIGHPDLLFVFDGDEIRNIFKKEEAMPHRPSMPSLRHYKGDLRRDFFGDVAGL 202
             ..||.|...  ..|....:.:.....:..:.::|...|.|.||...:.:     ||..|...|:
  Rat    92 -AKYGPMWTT--TFGTRTNVNLASAPLLEQVMRQEGKYPIRDSMEQWKEH-----RDHKGLSYGI 148

  Fly   203 IGVHGPKWEAFRQEVQHILLQPQTAKKYIPPLNDIASEFMGRIELMRDEK---DELPANFLHELY 264
            ....|.:|...|..:...:|:|..|..|...||::.|:|:.|::.:|.|.   |::| :..|.||
  Rat   149 FITQGQQWYHLRHSLNQRMLKPAEAALYTDALNEVISDFIARLDQVRTESASGDQVP-DVAHLLY 212

  Fly   265 KWALESVGRVSLDTRLGCLSPEGSEEAQQIIEAINTFF-----------WAVPELELRMPLWRIY 318
            ..|||::..:..:.|:|||.|...|:....|.::...|           |:.|.|    |.|:.|
  Rat   213 HLALEAICYILFEKRVGCLEPSIPEDTATFIRSVGLMFKNSVYVTFLPKWSRPLL----PFWKRY 273

  Fly   319 PTKAYRSFVKALDQFTAICMKNIGKTMDKADAD-EARGLSKSEADISIVERIVRKTGNRKLAAIL 382
                    :...|...:...|.|.:.:.:.:|. :|.|....:....:...:.::..:.:.....
  Rat   274 --------MNNWDNIFSFGEKMIHQKVQEIEAQLQAAGPDGVQVSGYLHFLLTKELLSPQETVGT 330

  Fly   383 ALDLFLVGVDTTSVAASSTIYQLAKNPDKQKKLFDELQKVFPHREADINQNVLEQMPYLRACVKE 447
            ..:|.|.||||||...:..:|.|:|||:.|:.|..|:..|.|..:...|:: ...||.|:|.:||
  Rat   331 FPELILAGVDTTSNTLTWALYHLSKNPEIQEALHKEVTGVVPFGKVPQNKD-FAHMPLLKAVIKE 394

  Fly   448 TLRMRPVVIANGRSL-QSDAVINGYHVPKGTHVIFPHLVVSNDPAYFPEPKRFLPERWL-KQSTD 510
            |||:.|||..|.|.: :.:..|||:..||.|..:..|.|||.||:.||||:.|.|.||| |:..|
  Rat   395 TLRLYPVVPTNSRIITEKETEINGFLFPKNTQFVLCHYVVSRDPSVFPEPESFQPHRWLRKREDD 459

  Fly   511 AAGCPHANQKIHPFVSLPFGFGRRMCVGRRFAEIELHTLLAKIFRKYKVSYNSG----EFVYRVN 571
            .:|..      |||.|:|||:|.|.|:|||.||:|:..||:::.:||:|..:.|    :.|.|:
  Rat   460 NSGIQ------HPFGSVPFGYGVRSCLGRRIAELEMQLLLSRLIQKYEVVLSPGMGEVKSVSRI- 517

  Fly   572 STYIPQSPLNFKLTLR 587
             ..:|...::.:...|
  Rat   518 -VLVPSKKVSLRFLQR 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp49a1	NP_001246256.1	p450	104..565	CDD:299894	140/481 (29%)
Cyp27a1	NP_849178.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	38..58		3/19 (16%)
		cytochrome_P450	91..527	CDD:425388	138/470 (29%)
		Sterol-binding. /evidence=ECO:0000255	386..400		8/13 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	196	1.000	Domainoid score	I3026
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H36040
Inparanoid	1	1.050	200	1.000	Inparanoid score	I3706
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8942
orthoMCL	1	0.900	-	-		OOG6_100895
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.770