DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp49a1 and Cyp24a1

DIOPT Version :9

Sequence 1:	NP_001246256.1	Gene:	Cyp49a1 / 36105	FlyBaseID:	FBgn0033524	Length:	589	Species:	Drosophila melanogaster
Sequence 2:	NP_963966.1	Gene:	Cyp24a1 / 25279	RGDID:	2462	Length:	514	Species:	Rattus norvegicus

Alignment Length:	552	Identity:	161/552 - (29%)
Similarity:	257/552 - (46%)	Gaps:	86/552 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 KKLNVSQQPVTSVATTRTTASSLPAETTSSPA---AAVRPYSEVPGPYPLPLIGN----SWRFAP 120
            ::|....||..|| |::.:||..|.|....|.   ...|..:.:|||...||:|:    .|:.
  Rat    16 RRLRDLGQPPRSV-TSKASASRAPKEVPLCPLMTDGETRNVTSLPGPTNWPLLGSLLEIFWKG-- 77

  Fly   121 LIGTYKISDLDKVMNELHVNYGKM--AKVGGL----IGHPDLLFVFDGDEIRNIFKKEEAMPHRP 179
              |..|..|   .:.|.|..||::  .|:|..    :|.|.||        ..:::.|.|.|.|.
  Rat    78 --GLKKQHD---TLAEYHKKYGQIFRMKLGSFDSVHLGSPSLL--------EALYRTESAHPQRL 129

  Fly   180 SMPSLRHYKGDLRRDFFGDVAGLIGVHGPKWEAFRQEVQHILLQPQTAKKYIPPLNDIASEFMGR 244
            .:...:.|     ||...:..||:.:.|.:|:..|...|..|::|....|....:|::.::|:.|
  Rat   130 EIKPWKAY-----RDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLER 189

  Fly   245 IELMRDEKDELPANFLHELYKWALESVGRVSLDTRLGCLSPEGSEEAQQIIEAINTFF-----WA 304
            ::.:.||:..:| :...||.||:.||:..|..:.|.|.|..|..|||...|.||.|..     ..
  Rat   190 MDELCDERGRIP-DLYSELNKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMM 253

  Fly   305 VPELELRMPLWRIYPTKAYRSFVKALDQ-FTAI--CMKN-IGKTMDKADAD------EARGLSKS 359
            |..:||...|    .||.:::...|.|. |.::  |:.| :.:...:..||      :...|||.
  Rat   254 VTPVELHKRL----NTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDHLSKK 314

  Fly   360 EADISIVERIVRKTGNRKLAAILALDLFLVGVDTTSVAASSTIYQLAKNPDKQKKLFDELQKVFP 424
            |...::.|                  |.|..|:||:.:....:|.|::||..|::|..|:|.|.|
  Rat   315 ELYAAVTE------------------LQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLP 361

  Fly   425 HREADINQNVLEQMPYLRACVKETLRMRPVVIANGRSLQSDAVINGYHVPKGTHVIFPHLVVSND 489
            ..:....:: |..||||:||:||::|:.|.|....|:|....|:..|.:||||.:.....|:.:.
  Rat   362 DNQTPRAED-LRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSS 425

  Fly   490 PAYFPEPKRFLPERWLKQSTDAAGCPHANQKIHPFVSLPFGFGRRMCVGRRFAEIELHTLLAKIF 554
            ...|.:..:|.|||||::          .:||:||..||||.|:|||:|||.||::||..|..|.
  Rat   426 EDNFEDSHKFRPERWLQK----------EKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWII 480

  Fly   555 RKYKVSYNSGEFVYRVN-STYIP--QSPLNFK 583
            :||.:.....|.|..:: ...:|  :.|:.|:
  Rat   481 QKYDIVATDNEPVEMLHLGILVPSRELPIAFR 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp49a1	NP_001246256.1	p450	104..565	CDD:299894	144/485 (30%)
Cyp24a1	NP_963966.1	CYP24A1	90..508	CDD:410738	136/464 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	200	1.000	Inparanoid score	I3706
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	1	1.000	-	-		FOG0000720
OrthoInspector	1	1.000	-	-		mtm8942
orthoMCL	1	0.900	-	-		OOG6_100895
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.770