DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp49a1 and Cyp12d1-p

DIOPT Version :9

Sequence 1:	NP_001246256.1	Gene:	Cyp49a1 / 36105	FlyBaseID:	FBgn0033524	Length:	589	Species:	Drosophila melanogaster
Sequence 2:	NP_001286304.1	Gene:	Cyp12d1-p / 246648	FlyBaseID:	FBgn0050489	Length:	521	Species:	Drosophila melanogaster

Alignment Length:	498	Identity:	150/498 - (30%)
Similarity:	266/498 - (53%)	Gaps:	25/498 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 VTSVATTRTTASSLPAETTSSPAAAVRPYSEVPGPYPLPLIGNSWRFAPLI---GTYKISDLDKV 133
            |..|.::|:.:.....:..||.....:.|.|:|.|       |.::|....   |.::.:.:.:.
  Fly    14 VGPVRSSRSASVLAHEQAKSSITEEHKTYDEIPRP-------NKFKFMRAFMPGGEFQNASITEY 71

  Fly   134 MNELHVNYGKMAKVGGLIGHPDLLFVFDGDEIRNIFKKEEAMPHRPSMPSLRHYKGDLRRDFFGD 198
            .:.:...||.:..:.|:.|..|.:..|:..:|..:|:.|...|.|..:.|:.:::..:|.|.:|:
  Fly    72 TSAMRKRYGDIYVMPGMFGRKDWVTTFNTKDIEMVFRNEGIWPRRDGLDSIVYFREHVRPDVYGE 136

  Fly   199 VAGLIGVHGPKWEAFRQEVQHILLQPQTAKKYIPPLNDIASEFMGRIELMRDEKD-ELPANFLHE 262
            |.||:......|...|..:..|.:||:..:.|..||::|.:||:.||:.:||.|. |:|.:|..|
  Fly   137 VQGLVASQNEAWGKLRSAINPIFMQPRGLRMYYEPLSNINNEFIERIKEIRDPKTLEVPEDFTDE 201

  Fly   263 LYKWALESVGRVSLDTRLGCL-SPEGSEEAQQIIEAINTFFWAVPELELRMPLWRIYPTKAYRSF 326
            :.:...||:|.|:.|.::|.: ....:.:|..:.:.....|....:|:::..:|:|..|..||..
  Fly   202 ISRLVFESLGLVAFDRQMGLIRKNRDNSDALTLFQTSRDIFRLTFKLDIQPSMWKIISTPTYRKM 266

  Fly   327 VKALDQFTAICMKNIGKTMDKADADEARGLSKSEADISIVERIVRKTGNRKLAAILALDLFLVGV 391
            .:.|:....:..|.:.:..|..:.....| .|..:: |::||::..  :.|:|.|::||:...||
  Fly   267 KRTLNDSLNVAQKMLKENQDALEKRRQAG-EKINSN-SMLERLMEI--DPKVAVIMSLDILFAGV 327

  Fly   392 DTTSVAASSTIYQLAKNPDKQKKLFDELQKVFPHREADINQNVLEQMPYLRACVKETLRMRPVVI 456
            |.|:...|:.:..|:|:||||.||.:||..:.|.:::.:|:..::.||||||.:|||||..|..:
  Fly   328 DATATLLSAVLLCLSKHPDKQAKLREELLSIMPTKDSLLNEENMKDMPYLRAVIKETLRYYPNGL 392

  Fly   457 ANGRSLQSDAVINGYHVPKGTHVIFPHLVVSNDPAYFPEPKRFLPERWLKQSTDAAGCPHANQK- 520
            ...|:.|:|.:::||.|||||.|:....|:..:..|:|.|..|||||||:.       |...:|
  Fly   393 GTMRTCQNDVILSGYRVPKGTTVLLGSNVLMKEATYYPRPDEFLPERWLRD-------PETGKKM 450

  Fly   521 -IHPFVSLPFGFGRRMCVGRRFAEIELHTLLAKIFRKYKVSYN 562
             :.||..||||||.|||:|:|..::|:.|.:||:.|.:.|.:|
  Fly   451 QVSPFTFLPFGFGPRMCIGKRVVDLEMETTVAKLIRNFHVEFN 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp49a1	NP_001246256.1	p450	104..565	CDD:299894	143/466 (31%)
Cyp12d1-p	NP_001286304.1	p450	70..508	CDD:299894	138/435 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2609
eggNOG	1	0.900	-	-		E2759_KOG0159
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3547
Isobase	1	0.950	-	0	Normalized mean entropy	S4770
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	1	1.000	-	-		FOG0000720
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24305
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
	10	9.920