DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp49a1 and CYP27B1

DIOPT Version :9

Sequence 1:	NP_001246256.1	Gene:	Cyp49a1 / 36105	FlyBaseID:	FBgn0033524	Length:	589	Species:	Drosophila melanogaster
Sequence 2:	NP_000776.1	Gene:	CYP27B1 / 1594	HGNCID:	2606	Length:	508	Species:	Homo sapiens

Alignment Length:	509	Identity:	149/509 - (29%)
Similarity:	228/509 - (44%)	Gaps:	56/509 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 AAVRPYSEVPGPYPLPLIGNSWRFAPLI---GTYKISDLDKVMNELHVNYGKMAKVGGL----IG 152
            :|.|..:::|||.....:      |.|.   |..::.:| :|....|.....:|..|.:    :.
Human    32 SARRSLADIPGPSTPSFL------AELFCKGGLSRLHEL-QVQGAAHFGPVWLASFGTVRTVYVA 89

  Fly   153 HPDLLFVFDGDEIRNIFKKEEAMPHRPSM-PSLRHYKGDLRRDFFGDVAGLIGVHGPKWEAFRQE 216
            .|.|        :..:.::|...|.|.|. |...|.:...|      ..||:...|.:|:..|..
Human    90 APAL--------VEELLRQEGPRPERCSFSPWTEHRRCRQR------ACGLLTAEGEEWQRLRSL 140

  Fly   217 VQHILLQPQTAKKYIPPLNDIASEFMGRIELMRDEKDELPA---NFLHELYKWALESVGRVSLDT 278
            :..:||:||.|.:|...||::..:.:.|:...|......||   :...|.||:.||.:..|.|.:
Human   141 LAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGS 205

  Fly   279 RLGCLSPEGSEEAQQIIEAINTFFWAVPELELRMPLW-RIYPTKAYRSFVKALDQFTAICMKNIG 342
            |||||..:...:.:..|.|:.:.|.:. .|.:.||.| |......:....:..||..|...:::
Human   206 RLGCLEAQVPPDTETFIRAVGSVFVST-LLTMAMPHWLRHLVPGPWGRLCRDWDQMFAFAQRHV- 268

  Fly   343 KTMDKADADEA-RGLSKSEADISIVERIVRKTGNRKLAAILAL----DLFLVGVDTTSVAASSTI 402
               ::.:|:.| |...:.|.|:.....:.......:|.|...|    :|.|.||||.|...|..:
Human   269 ---ERREAEAAMRNGGQPEKDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVSNTLSWAL 330

  Fly   403 YQLAKNPDKQKKLFDELQKVF-PHREADINQNVLEQMPYLRACVKETLRMRPVVIANGRSLQSDA 466
            |:|:::|:.|..|..|:.... |...|..:..||.|:|.|:|.|||.||:.|||..|.|....|.
Human   331 YELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDI 395

  Fly   467 VINGYHVPKGTHVIFPHLVVSNDPAYFPEPKRFLPERWLKQSTDAAGCPHANQKIHPFVSLPFGF 531
            .:..|.:||.|.|...|...|.|||.||||..|.|.|||.:....          |||.||||||
Human   396 HVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTP----------HPFASLPFGF 450

  Fly   532 GRRMCVGRRFAEIELHTLLAKIFRKYKVSYNSGEFVYR--VNSTYIPQSPLNFK 583
            |:|.|:|||.||:||...||:|...::|....|....|  ..:..:|:..:|.:
Human   451 GKRSCMGRRLAELELQMALAQILTHFEVQPEPGAAPVRPKTRTVLVPERSINLQ 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp49a1	NP_001246256.1	p450	104..565	CDD:299894	143/478 (30%)
CYP27B1	NP_000776.1	p450	41..505	CDD:278495	147/500 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	194	1.000	Domainoid score	I3171
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	201	1.000	Inparanoid score	I3768
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8467
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2442
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.900