Protein Alignment Cyp49a1 and CYP24A1

DIOPT Version :9

• Sequence 1: NP_001246256.1
• Gene: Cyp49a1 / 36105
• FlyBaseID: FBgn0033524
• Length: 589
• Species: Drosophila melanogaster
• Sequence 2: NP_000773.2
• Gene: CYP24A1 / 1591
• HGNCID: 2602
• Length: 514
• Species: Homo sapiens
• Alignment Length: 565
• Identity: 171/565 - (30%)
• Similarity: 264/565 - (46%)
• Gaps: 91/565 - (16%)

  Fly    47 KSIA--MQRLRTGESSNPKKLNVSQQPVTSVATTRTTASSLPAETTSSPAAA---VRPYSEVPGP 106
            :|:|  :|:||:  ...|.:|      |||.|.|    |..|.|....|..|   .:..:.:|||
Human     9 RSLAAFLQQLRS--PRQPPRL------VTSTAYT----SPQPREVPVCPLTAGGETQNAAALPGP 61

  Fly   107 YPLPLIGNSWRFAPLIGTYKISDLDKVMNELHVNYGKM--AKVGGL----IGHPDLLFVFDGDEI 165
            ...||:|:..:.....|..|..|   .:.|.|..|||:  .|:|..    :|.|.||
Human    62 TSWPLLGSLLQILWKGGLKKQHD---TLVEYHKKYGKIFRMKLGSFESVHLGSPCLL-------- 115

  Fly   166 RNIFKKEEAMPHRPSMPSLRHYKGDLRRDFFGDVAGLIGVHGPKWEAFRQEVQHILLQPQTAKKY 230
            ..:::.|.|.|.|..:...:.|: |.|::.:    ||:.:.|..|:..|...|..|::|....|.
Human   116 EALYRTESAYPQRLEIKPWKAYR-DYRKEGY----GLLILEGEDWQRVRSAFQKKLMKPGEVMKL 175

  Fly   231 IPPLNDIASEFMGRIELMRDEKDELPANFLHELYKWALESVGRVSLDTRLGCLSPEGSEEAQQII 295
            ...:|::.::|||||:.:.||:..: .:...||.||:.||:..|..:.|.|.|.....:||...|
Human   176 DNKINEVLADFMGRIDELCDERGHV-EDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFI 239

  Fly   296 EAINTFF-----WAVPELELRMPLWRIYPTKAYRSFVKALDQ-FTAI--CMKN-IGKTMDKADAD 351
            .||.|..     ..|..:||...|    .||.::....|.|. |.::  |:.| :.|...:..||
Human   240 MAIKTMMSTFGRMMVTPVELHKSL----NTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPSAD 300

  Fly   352 ------EARGLSKSEADISIVERIVRKTGNRKLAAILALDLFLVGVDTTSVAASSTIYQLAKNPD 410
                  ....|||.|...::.|                  |.|..|:||:.:....:|.|::||.
Human   301 FLCDIYHQNRLSKKELYAAVTE------------------LQLAAVETTANSLMWILYNLSRNPQ 347

  Fly   411 KQKKLFDELQKVFPHREADINQNVLEQMPYLRACVKETLRMRPVVIANGRSLQSDAVINGYHVPK 475
            .|:||..|:|.|.|..:....:: |..||||:||:||::|:.|.|....|:|....|:..|.:||
Human   348 VQQKLLKEIQSVLPENQVPRAED-LRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPK 411

  Fly   476 GTHVIFPHLVVSNDPAYFPEPKRFLPERWLKQSTDAAGCPHANQKIHPFVSLPFGFGRRMCVGRR 540
            ||.::....|:.:....|.:..:|.|||||::          .:||:||..||||.|:|||:|||
Human   412 GTVLMLNTQVLGSSEDNFEDSSQFRPERWLQE----------KEKINPFAHLPFGVGKRMCIGRR 466

  Fly   541 FAEIELHTLLAKIFRKYKVSYNSGEFVYRVNS-TYIP--QSPLNF 582
            .||::||..|..|.|||.:.....|.|..::| |.:|  :.|:.|
Human   467 LAELQLHLALCWIVRKYDIQATDNEPVEMLHSGTLVPSRELPIAF 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp49a1	NP_001246256.1	p450	104..565	CDD:299894	147/481 (31%)
CYP24A1	NP_000773.2	p450	59..512	CDD:278495	154/503 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	194	1.000	Domainoid score	I3171
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	201	1.000	Inparanoid score	I3768
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	1	1.000	-	-		FOG0000720
OrthoInspector	1	1.000	-	-		mtm8467
orthoMCL	1	0.900	-	-		OOG6_100895
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2442
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.800