Protein Alignment Cyp49a1 and CYP11B1

DIOPT Version :10

• Sequence 1: NP_610588.2
• Gene: Cyp49a1 / 36105
• FlyBaseID: FBgn0033524
• Length: 589
• Species: Drosophila melanogaster
• Sequence 2: NP_000488.3
• Gene: CYP11B1 / 1584
• HGNCID: 2591
• Length: 503
• Species: Homo sapiens
• Alignment Length: 527
• Identity: 135/527 - (25%)
• Similarity: 236/527 - (44%)
• Gaps: 71/527 - (13%)

  Fly    80 TTASSLPAETTSSPAAAVRPYSEVPGPYPLPLIGNSWRFAPLIGTYKISDLDKVMNELHVNYGKM 144
            |.|:.:|.......|...||             ||.|  ..|:..::....:.:..|:|..:.::
Human    26 TRAARVPRTVLPFEAMPRRP-------------GNRW--LRLLQIWREQGYEDLHLEVHQTFQEL 75

  Fly   145 AKVGGL-IGHPDLLFVFDGDEIRNIFKKEEAMPHRPSMPSLRHYKGDLRRDFFGDVAGLIGVHGP 208
            ..:... :|...::.|...:::..:.:.:...|||.|:.....|     |...|...|:..::||
Human    76 GPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAY-----RQHRGHKCGVFLLNGP 135

  Fly   209 KWEAFRQEVQHILLQPQTAKKYIPPLNDIASEFMGRI--ELMRDEKDELPANFLHELYKWALESV 271
            :|...|..:...:|.|...::::|.::.:|.:|...:  :::::.:..|..:....::.:.:|:.
Human   136 EWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEAS 200

  Fly   272 GRVSLDTRLGCLSPEGSEEAQQIIEAINTFFWAVPELELRMP--LWRIYPTKAYRSFVKALD--- 331
            .......|||.:....|..:...:.|:...|.:..:| :.||  |.|....|.::...:|.|
Human   201 NLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQL-MFMPRSLSRWTSPKVWKEHFEAWDCIF 264

  Fly   332 QFTAICMKNIGKTMDKADADEARGLSKSEADISIVERIVRKTGNRKLA--AILA--LDLFLVGVD 392
            |:...|::.|.:.:         ..|:.:...|||..::.   |.:|:  ||.|  ::|....||
Human   265 QYGDNCIQKIYQEL---------AFSRPQQYTSIVAELLL---NAELSPDAIKANSMELTAGSVD 317

  Fly   393 TTSVAASSTIYQLAKNPDKQKKLFDE----LQKVFPHREADINQNVLEQMPYLRACVKETLRMRP 453
            ||......|:::||:||:.|:.|..|    ...:..|     .|....::|.|||.:|||||:.|
Human   318 TTVFPLLMTLFELARNPNVQQALRQESLAAAASISEH-----PQKATTELPLLRAALKETLRLYP 377

  Fly   454 VVIANGRSLQSDAVINGYHVPKGTHV-IFPHLVVSNDPAYFPEPKRFLPERWLKQSTDAAGCPHA 517
            |.:...|...||.|:..||:|.||.| :|.:.:..| ||.||.|:|:.|:|||    |..|..
Human   378 VGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRN-PALFPRPERYNPQRWL----DIRGSG-- 435

  Fly   518 NQKIHPFVSLPFGFGRRMCVGRRFAEIELHTLLAKIFRKYKVSYNSGEFVYRVNSTYIPQS--PL 580
                ..|..:|||||.|.|:|||.||.|:..||..:.:..:|...:.|.:..|.|..:..|  ||
Human   436 ----RNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPL 496

  Fly   581 NFKLTLR 587
               ||.|
Human   497 ---LTFR 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp49a1	NP_610588.2	CYP24A1-like	138..581	CDD:410677	120/461 (26%)
CYP11B1	NP_000488.3	CYP11B	72..499	CDD:410737	121/463 (26%)