DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp49a1 and CYP11B1

DIOPT Version :9

Sequence 1:	NP_001246256.1	Gene:	Cyp49a1 / 36105	FlyBaseID:	FBgn0033524	Length:	589	Species:	Drosophila melanogaster
Sequence 2:	NP_000488.3	Gene:	CYP11B1 / 1584	HGNCID:	2591	Length:	503	Species:	Homo sapiens

Alignment Length:	527	Identity:	135/527 - (25%)
Similarity:	236/527 - (44%)	Gaps:	71/527 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 TTASSLPAETTSSPAAAVRPYSEVPGPYPLPLIGNSWRFAPLIGTYKISDLDKVMNELHVNYGKM 144
            |.|:.:|.......|...||             ||.|  ..|:..::....:.:..|:|..:.::
Human    26 TRAARVPRTVLPFEAMPRRP-------------GNRW--LRLLQIWREQGYEDLHLEVHQTFQEL 75

  Fly   145 AKVGGL-IGHPDLLFVFDGDEIRNIFKKEEAMPHRPSMPSLRHYKGDLRRDFFGDVAGLIGVHGP 208
            ..:... :|...::.|...:::..:.:.:...|||.|:.....|     |...|...|:..::||
Human    76 GPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAY-----RQHRGHKCGVFLLNGP 135

  Fly   209 KWEAFRQEVQHILLQPQTAKKYIPPLNDIASEFMGRI--ELMRDEKDELPANFLHELYKWALESV 271
            :|...|..:...:|.|...::::|.::.:|.:|...:  :::::.:..|..:....::.:.:|:.
Human   136 EWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEAS 200

  Fly   272 GRVSLDTRLGCLSPEGSEEAQQIIEAINTFFWAVPELELRMP--LWRIYPTKAYRSFVKALD--- 331
            .......|||.:....|..:...:.|:...|.:..:| :.||  |.|....|.::...:|.|
Human   201 NLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQL-MFMPRSLSRWTSPKVWKEHFEAWDCIF 264

  Fly   332 QFTAICMKNIGKTMDKADADEARGLSKSEADISIVERIVRKTGNRKLA--AILA--LDLFLVGVD 392
            |:...|::.|.:.:         ..|:.:...|||..::.   |.:|:  ||.|  ::|....||
Human   265 QYGDNCIQKIYQEL---------AFSRPQQYTSIVAELLL---NAELSPDAIKANSMELTAGSVD 317

  Fly   393 TTSVAASSTIYQLAKNPDKQKKLFDE----LQKVFPHREADINQNVLEQMPYLRACVKETLRMRP 453
            ||......|:::||:||:.|:.|..|    ...:..|     .|....::|.|||.:|||||:.|
Human   318 TTVFPLLMTLFELARNPNVQQALRQESLAAAASISEH-----PQKATTELPLLRAALKETLRLYP 377

  Fly   454 VVIANGRSLQSDAVINGYHVPKGTHV-IFPHLVVSNDPAYFPEPKRFLPERWLKQSTDAAGCPHA 517
            |.:...|...||.|:..||:|.||.| :|.:.:..| ||.||.|:|:.|:|||    |..|..
Human   378 VGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRN-PALFPRPERYNPQRWL----DIRGSG-- 435

  Fly   518 NQKIHPFVSLPFGFGRRMCVGRRFAEIELHTLLAKIFRKYKVSYNSGEFVYRVNSTYIPQS--PL 580
                ..|..:|||||.|.|:|||.||.|:..||..:.:..:|...:.|.:..|.|..:..|  ||
Human   436 ----RNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPL 496

  Fly   581 NFKLTLR 587
               ||.|
Human   497 ---LTFR 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp49a1	NP_001246256.1	p450	104..565	CDD:299894	120/477 (25%)
CYP11B1	NP_000488.3	p450	42..454	CDD:365848	114/460 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820