DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cyp49a1 and CYP11A1

DIOPT Version :9

Sequence 1:NP_001246256.1 Gene:Cyp49a1 / 36105 FlyBaseID:FBgn0033524 Length:589 Species:Drosophila melanogaster
Sequence 2:NP_000772.2 Gene:CYP11A1 / 1583 HGNCID:2590 Length:521 Species:Homo sapiens


Alignment Length:596 Identity:145/596 - (24%)
Similarity:251/596 - (42%) Gaps:130/596 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 PHSGGVGGA---VSPPSSGVGVATEIEKSIAMQRLR--TGESSNPKKLNVSQQPVTSVATTRTTA 82
            |.|..|.|.   :|.|..|:|            |||  |||.:                      
Human     8 PRSVLVKGCQTFLSAPREGLG------------RLRVPTGEGA---------------------- 38

  Fly    83 SSLPAETTSSPAAAVRPYSEVPGPYPLPLIGNSW----RFAPLIGTYKISDLDKVMNELHVNYGK 143
                ..:|.||    ||::|:|.|.     .|.|    .|....||:|: .|..|.|  ...||.
Human    39 ----GISTRSP----RPFNEIPSPG-----DNGWLNLYHFWRETGTHKV-HLHHVQN--FQKYGP 87

  Fly   144 MAKVGGLIGHPDLLFVFDGDEIRNIFKKEEAMPHRPSMPSLRHYKGDLRRDFFGDVAGLIGVHGP 208
            :.:  ..:|:.:.::|.|.:::..:||.|...|.|..:|....|     ..::....|::.....
Human    88 IYR--EKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAY-----HQYYQRPIGVLLKKSA 145

  Fly   209 KWEAFRQEVQHILLQPQTAKKYIPPLNDIASEFMGRI--ELMRDEKDELPANFLHELYKWALESV 271
            .|:..|..:...::.|:..|.::|.|:.::.:|:..:  .:.:........:...:|:::|.||:
Human   146 AWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESI 210

  Fly   272 GRVSLDTRLGCLSPEGSEEAQQIIEAI-NTFFWAVPELELRMPLWRIYPTKAYRSFVKALDQFTA 335
            ..|....|.|.|....:.|||:.|:|| ..|..:||.|.|...|:|::.||.::..|.|.|..  
Human   211 TNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVI-- 273

  Fly   336 ICMKNIGKTMDKADA----------------DEARGLSKSEADISIVERIVRKTGNRKLA----A 380
                     ..|||.                .:.||:            :.|..|:.|::    .
Human   274 ---------FSKADIYTQNFYWELRQKGSVHHDYRGI------------LYRLLGDSKMSFEDIK 317

  Fly   381 ILALDLFLVGVDTTSVAASSTIYQLAKNPDKQKKLFDELQKVFPHREADINQNVLEQMPYLRACV 445
            ....::...||||||:.....:|::|:|...|..|..|:.......:.|: ..:|:.:|.|:|.:
Human   318 ANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDM-ATMLQLVPLLKASI 381

  Fly   446 KETLRMRPVVIANGRSLQSDAVINGYHVPKGTHVIFPHLVVSNDPAYFPEPKRFLPERWLKQSTD 510
            |||||:.|:.:...|.|.:|.|:..|.:|..|.|......:..:|.:|.:|:.|.|.|||.:   
Human   382 KETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSK--- 443

  Fly   511 AAGCPHANQKIHPFVSLPFGFGRRMCVGRRFAEIELHTLLAKIFRKYKVSYNSGEFVYRVNSTY- 574
                   ::.|..|.:|.||:|.|.|:|||.||:|:...|..:...::|..   :.:..|.:|: 
Human   444 -------DKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEI---QHLSDVGTTFN 498

  Fly   575 ---IPQSPLNF 582
               :|:.|::|
Human   499 LILMPEKPISF 509

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cyp49a1NP_001246256.1 p450 104..565 CDD:299894 120/487 (25%)
CYP11A1NP_000772.2 p450 52..511 CDD:278495 125/510 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0159
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D185685at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm8467
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2442
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.850

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